AiPD: Autoinhibited Protein Database

P56182

Gene name	RRP1 (D21S2056E, NNP1, NOP52, RRP1A)
Protein name	Ribosomal RNA processing protein 1 homolog A
Names	Novel nuclear protein 1, NNP-1, Nucleolar protein Nop52, RRP1-like protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8568
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

206-295 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

206-295 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

5 structures for P56182

Entry ID	Method	Resolution	Chain	Position	Source
8FKP	EM	285 A	NO	1-461	PDB
8FKR	EM	289 A	NO	1-461	PDB
8FKT	EM	281 A	NO	1-461	PDB
8FKV	EM	247 A	NO	1-461	PDB
AF-P56182-F1	Predicted				AlphaFoldDB

461 variants for P56182

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA058439 RCV000207187 rs763767114	114	R>C	Ductal breast carcinoma [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1452399333 CA410400609	2	V>A		No	ClinGen TOPMed
rs751693513 CA10048990	2	V>I		No	ClinGen ExAC gnomAD
rs867558058 CA321688114	3	S>*		No	ClinGen Ensembl
CA410400645 rs1449005912	5	V>A		No	ClinGen TOPMed
rs1375507678 CA410400639	5	V>M		No	ClinGen gnomAD
rs1312463592 CA410400656	7	L>F		No	ClinGen gnomAD
rs746135596 CA10048993	8	P>L		No	ClinGen ExAC gnomAD
CA410400675 rs1481499111	10	E>A		No	ClinGen gnomAD
CA410400715 rs1199175403	12	Q>H		No	ClinGen gnomAD
CA10048994 rs756401494	13	L>V		No	ClinGen ExAC gnomAD
rs866593435 CA321688128	15	Q>H		No	ClinGen gnomAD
CA410400760 rs1195629456	16	R>C		No	ClinGen gnomAD
rs1268176675 CA410400768	16	R>H		No	ClinGen gnomAD
CA410400762 rs1195629456	16	R>S		No	ClinGen gnomAD
rs1375084510 CA410400779	17	L>P		No	ClinGen gnomAD
rs1421524683 CA410400785	18	A>P		No	ClinGen TOPMed
CA10048996 rs749605541	19	G>R		No	ClinGen ExAC TOPMed gnomAD
CA10048998 rs774679026	20	N>S		No	ClinGen ExAC TOPMed gnomAD
CA410400823 rs1327278262	21	E>K		No	ClinGen TOPMed gnomAD
rs1367695860 CA410400829	21	E>V		No	ClinGen gnomAD
CA410400839 rs770392911	22	Q>*		No	ClinGen ExAC gnomAD
CA10049000 rs770392911	22	Q>K		No	ClinGen ExAC gnomAD
rs530432421 CA10049001	22	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	23	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410400851 rs1441139807	23	V>M		No	ClinGen gnomAD
rs1014136422 CA321688163	25	R>Q		No	ClinGen TOPMed
CA410400904 rs1286070892	27	R>Q		No	ClinGen TOPMed
rs548567025 CA10049003	29	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1488206650 CA410400930	30	R>G		No	ClinGen gnomAD
CA410400960 rs1314447706	32	L>F		No	ClinGen TOPMed
CA10049005 rs762699166	33	R>Q		No	ClinGen ExAC gnomAD
CA410401002 rs1193462432	35	Y>C		No	ClinGen gnomAD
rs1421965956 CA410401024	37	V>F		No	ClinGen gnomAD
rs1166122146 CA410401037	38	A>S		No	ClinGen TOPMed gnomAD
rs1349942219 CA410401043	38	A>V		No	ClinGen gnomAD
CA10049007 rs751501362	39	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1291398276 CA410401067	40	T>S		No	ClinGen gnomAD
CA10049008 rs757206842	44	A>S		No	ClinGen ExAC TOPMed gnomAD
CA410401116 rs1235002051	45	G>S		No	ClinGen gnomAD
rs114632703 CA10049023	48	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs114632703 CA10049024	48	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10049027 rs750490127	50	D>A		No	ClinGen ExAC
CA321689527 rs987774479	50	D>N		No	ClinGen TOPMed gnomAD
rs1332910932 CA410401517	51	E>*		No	ClinGen gnomAD
TCGA novel	51	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1332910932 CA410401515	51	E>Q		No	ClinGen gnomAD
CA10049030 rs754160691	54	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10049029 rs766533429	54	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1200752656 CA410401665	62	C>*		No	ClinGen TOPMed gnomAD
CA10049032 rs779207686	63	M>L		No	ClinGen ExAC TOPMed gnomAD
CA10049033 rs753052026	63	M>R		No	ClinGen ExAC
CA410401670 rs779207686	63	M>V		No	ClinGen ExAC TOPMed gnomAD
rs747485764 CA10049036	64	W>C		No	ClinGen ExAC gnomAD
CA10049034 rs758854546	64	W>G		No	ClinGen ExAC
CA10049035 rs758854546	64	W>R		No	ClinGen ExAC
CA10049041 rs774030035	65	M>I		No	ClinGen ExAC TOPMed gnomAD
CA10049039 rs779527474	65	M>K		No	ClinGen ExAC gnomAD
CA10049037 rs769345136	65	M>L		No	ClinGen ExAC TOPMed
CA10049038 rs779527474	65	M>R		No	ClinGen ExAC gnomAD
CA10049040 rs779527474	65	M>T		No	ClinGen ExAC gnomAD
CA410401715 rs761619063	66	Q>*		No	ClinGen ExAC gnomAD
rs761619063 CA10049042	66	Q>E		No	ClinGen ExAC gnomAD
rs773320493 CA10049046	66	Q>H		No	ClinGen ExAC
CA10049043 rs761619063	66	Q>K		No	ClinGen ExAC gnomAD
CA10049044 rs1555889809	66	Q>R		No	ClinGen Ensembl
rs201407956 CA10049048 CA10049049	67	D>E		No	ClinGen ExAC TOPMed gnomAD
CA10049047 rs760664822	67	D>N		No	ClinGen ExAC gnomAD
CA410401739 rs1168462993	68	K>E		No	ClinGen gnomAD
rs897169803 CA321689634	68	K>R		No	ClinGen TOPMed gnomAD
CA10049051 rs765454845	71	L>F		No	ClinGen ExAC TOPMed gnomAD
rs771995948 CA10049080	73	E>G		No	ClinGen ExAC TOPMed gnomAD
rs771995948 CA410402356	73	E>V		No	ClinGen ExAC TOPMed gnomAD
CA10049081 rs747889574	74	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs747889574 CA10049082	74	E>Q		No	ClinGen ExAC gnomAD
CA321690563 rs1054970949	76	G>A		No	ClinGen TOPMed gnomAD
rs777710952 CA410402432	77	R>K		No	ClinGen ExAC TOPMed gnomAD
rs777710952 CA10049083	77	R>M		No	ClinGen ExAC TOPMed gnomAD
CA10049085 rs771027384	79	I>V		No	ClinGen ExAC gnomAD
CA410402505 rs1356423002	81	Q>H		No	ClinGen gnomAD
CA10049087 rs776753739	83	V>F		No	ClinGen ExAC TOPMed gnomAD
CA10049086 rs776753739	83	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1016534662 CA321690570	84	H>N		No	ClinGen TOPMed gnomAD
rs769976627 CA10049088	85	A>G		No	ClinGen ExAC
rs763243729 CA10049090	87	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA10049089 rs371605643	87	Q>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs764243391 CA10049091	88	T>N		No	ClinGen ExAC gnomAD
rs1260163120 CA410402654	89	T>A		No	ClinGen gnomAD
rs531306920 CA10049092	89	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10049094 rs767836326	90	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10049095 rs750986561	91	A>G		No	ClinGen ExAC gnomAD
CA10049123 rs779817474	93	H>N		No	ClinGen ExAC gnomAD
CA10049124 CA410402906 rs114296196	93	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA410402894 rs779817474	93	H>Y		No	ClinGen ExAC gnomAD
CA410402910 rs1294914791	94	L>V		No	ClinGen TOPMed gnomAD
CA410402950 rs1390937041	97	Q>E		No	ClinGen gnomAD
CA10049125 rs768772947	97	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA410402970 rs1281100546	98	A>D		No	ClinGen gnomAD
rs746930949 CA321690964	99	F>S		No	ClinGen Ensembl
rs1219145935 CA410403005	100	W>C		No	ClinGen TOPMed gnomAD
CA410403052 CA321690973 rs546860126	103	M>I		No	ClinGen 1000Genomes TOPMed
rs1050893842 CA321690968	103	M>V		No	ClinGen gnomAD
CA10049127 rs748434339	105	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs768764518 CA321690999	105	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA321691027 rs982540625	106	E>D		No	ClinGen TOPMed
rs369505824 CA10049129	106	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs760895439 CA10049130	108	T>M		No	ClinGen ExAC TOPMed gnomAD
CA410403128 rs1478379410	109	G>S		No	ClinGen gnomAD
CA10049134 rs751047987	114	R>H		No	ClinGen ExAC TOPMed gnomAD
rs761572987 CA10049135	117	K>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	118	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410403267 rs1423556649	118	F>L		No	ClinGen gnomAD
rs1300965054 CA410403292	120	M>L		No	ClinGen gnomAD
CA410403294 rs1394833264	120	M>T		No	ClinGen Ensembl
CA410403290 rs1300965054	120	M>V		No	ClinGen gnomAD
CA10049162 rs777897637	121	L>P		No	ClinGen ExAC gnomAD
CA410403705 rs757437914	122	M>L		No	ClinGen ExAC gnomAD
rs781700913 CA10049165	122	M>T		No	ClinGen ExAC TOPMed gnomAD
CA10049164 rs757437914	122	M>V		No	ClinGen ExAC gnomAD
CA10049167 COSM1264612 rs374122140	123	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA10049166 rs746186788	123	R>W		No	ClinGen ExAC gnomAD
rs1333405815 CA410403742	124	M>I		No	ClinGen gnomAD
rs776181908 CA10049168	124	M>T		No	ClinGen ExAC gnomAD
rs749788511 CA321692577 CA410403791	127	N>K		No	ClinGen ExAC gnomAD
rs1377776608 CA410403784	127	N>S		No	ClinGen gnomAD
rs772774157 CA10049171	128	E>A		No	ClinGen ExAC TOPMed gnomAD
CA10049170 rs367993051	128	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA410403797 rs367993051	128	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1296244309 CA410403846	131	K>E		No	ClinGen TOPMed
rs1463391171 CA410403855	132	V>F		No	ClinGen TOPMed
CA410403860 rs1262925976	133	L>V		No	ClinGen gnomAD
rs1469328784 CA410403878	135	M>I		No	ClinGen TOPMed
rs1321949178 CA410403877	135	M>T		No	ClinGen TOPMed gnomAD
rs1397880153 CA410403874	135	M>V		No	ClinGen TOPMed gnomAD
rs760248566 CA10049172	136	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1259373530 CA410403902	137	G>V		No	ClinGen gnomAD
rs1601868779 CA410403944	139	E>D		No	ClinGen Ensembl
rs765996018 CA10049173	140	E>A		No	ClinGen ExAC gnomAD
rs1178797749 CA410403966	141	R>G		No	ClinGen TOPMed
CA10049221 rs750460535	144	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs766658198 CA10049223	148	E>K		No	ClinGen ExAC gnomAD
rs754182732 CA10049224	150	L>P		No	ClinGen ExAC TOPMed gnomAD
CA321693839 rs775222458	153	E>K		No	ClinGen Ensembl
rs753301682 CA10049227	154	I>V		No	ClinGen ExAC gnomAD
CA410404667 rs1601870611	156	H>P		No	ClinGen Ensembl
rs758838830 CA10049228	157	P>R		No	ClinGen ExAC gnomAD
rs1306464918 CA410404699	157	P>S		No	ClinGen Ensembl
rs1569015298 CA410404759	159	S>I		No	ClinGen Ensembl
rs745338361 CA10049230	159	S>R		No	ClinGen ExAC gnomAD
CA410404818 rs1378731628	161	A>V		No	ClinGen gnomAD
rs1363557520 CA410404860	162	P>R		No	ClinGen gnomAD
CA10049234 rs768554861	163	N>S		No	ClinGen ExAC TOPMed gnomAD
CA10049236 rs748099910	164	G>D		No	ClinGen ExAC gnomAD
rs1469744469 CA410404895	164	G>S		No	ClinGen gnomAD
rs1448504124 CA410404919	165	V>M		No	ClinGen TOPMed gnomAD
rs1439091704 CA410404981	167	S>N		No	ClinGen TOPMed
rs891234992 CA410405118	172	I>M		No	ClinGen gnomAD
rs766335419 CA10049240	172	I>T		No	ClinGen ExAC gnomAD
CA10049239 rs760793666	172	I>V		No	ClinGen ExAC gnomAD
CA410405271 rs1569015365	180	V>A		No	ClinGen Ensembl
TCGA novel	181	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1438604202 CA410405289	181	G>V		No	ClinGen TOPMed
rs988228931 CA321693938	182	A>T		No	ClinGen TOPMed gnomAD
rs1569015375 CA410405304	182	A>V		No	ClinGen Ensembl
rs758930459 CA10049245	183	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10049246 rs764549852	184	E>A		No	ClinGen ExAC TOPMed gnomAD
CA10049247 rs752030642	184	E>D		No	ClinGen ExAC gnomAD
CA321693944 rs1018295414	184	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA410405394 rs1460106035	185	L>F		No	ClinGen gnomAD
rs778389533 CA10049271	185	L>H		No	ClinGen ExAC TOPMed gnomAD
rs140646060 CA410405411	186	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10049272 rs140646060	186	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10049275 rs747008262	190	N>T		No	ClinGen ExAC TOPMed gnomAD
rs781358683 CA10049277	192	K>N		No	ClinGen ExAC gnomAD
rs34224504 CA10049279	194	I>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs34224504 CA10049278 VAR_053894	194	I>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1359155313 CA410405549	195	D>G		No	ClinGen gnomAD
rs371737632 CA10049281	195	D>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs371737632 COSM1264610 CA10049282	195	D>N	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs774633179 CA10049283	198	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA321694092 rs751552058	199	R>G		No	ClinGen gnomAD
rs1486454584 CA410405609	199	R>I		No	ClinGen gnomAD
CA410405607 rs1486454584	199	R>T		No	ClinGen gnomAD
rs2838378 CA410405622	200	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10049284 rs376009014	200	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs753419754 CA10049286	201	A>P		No	ClinGen ExAC TOPMed gnomAD
rs753419754 CA410405623	201	A>S		No	ClinGen ExAC TOPMed gnomAD
rs753419754 CA10049287 COSM1031184	201	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1418904506 CA410405631	202	A>V		No	ClinGen TOPMed
rs372422903 CA410405633	203	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA10049289 rs752452177	203	R>Q		No	ClinGen ExAC gnomAD
rs372422903 CA10049288	203	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs758116144 CA10049290	204	T>A		No	ClinGen ExAC gnomAD
CA410405682 rs551764515	209	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs551764515 CA10049311	209	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10049313 rs201870763	211	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA10049314 rs755980170	212	N>S		No	ClinGen ExAC TOPMed gnomAD
CA410405746 rs1405558946	214	T>I		No	ClinGen gnomAD
TCGA novel	214	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780122512 CA10049315	215	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs771526495 CA10049316	215	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA410405781 rs1468357301	217	I>M		No	ClinGen gnomAD
CA10049317 rs755223651	217	I>V		No	ClinGen ExAC gnomAD
rs373040342 CA10049318	220	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs202035823 CA10049320	221	I>T		No	ClinGen 1000Genomes ExAC gnomAD
rs773617935 CA10049321	225	A>S		No	ClinGen ExAC TOPMed gnomAD
rs773617935 CA410405906	225	A>T		No	ClinGen ExAC TOPMed gnomAD
rs747472096 CA10049322	225	A>V		No	ClinGen ExAC gnomAD
rs1353860457 COSM444551 CA410405930	226	P>L	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA410405922 rs1252943107	226	P>S		No	ClinGen TOPMed gnomAD
CA410405976 rs1415824343	229	I>T		No	ClinGen TOPMed
rs762594727 CA10049325	229	I>V		No	ClinGen ExAC
rs1322196689 CA410406017	231	D>G		No	ClinGen gnomAD
rs763679263 CA10049326	232	L>I		No	ClinGen ExAC gnomAD
rs763679263 CA10049327	232	L>V		No	ClinGen ExAC gnomAD
rs1287666272 CA410406114	237	D>E		No	ClinGen TOPMed
CA410406105 rs1360420851	237	D>G		No	ClinGen TOPMed
rs761522934 CA10049328	239	Q>R		No	ClinGen ExAC gnomAD
rs767222092 CA10049329	241	E>D		No	ClinGen ExAC TOPMed gnomAD
rs951064307 CA321694397	241	E>K		No	ClinGen TOPMed
CA410406185 rs1230938888	242	E>Q		No	ClinGen gnomAD
CA10049330 rs750177255	242	E>V		No	ClinGen ExAC gnomAD
CA410406204 rs1477384765	243	V>G		No	ClinGen TOPMed
rs200537007 CA10049331	243	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1428445931 CA410406210	244	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs753741244 CA10049334	245	S>L		No	ClinGen ExAC TOPMed gnomAD
CA10049336 rs371358839	246	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA10049337 rs748385452	247	S>G		No	ClinGen ExAC TOPMed gnomAD
rs758578096 CA10049338	247	S>I		No	ClinGen ExAC gnomAD
CA10049340 CA10049339 rs567553240	248	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770351031 CA321694423	248	D>G		No	ClinGen gnomAD
CA10049341 rs771393239	249	E>D		No	ClinGen ExAC gnomAD
rs777328464 CA10049342	250	S>F		No	ClinGen ExAC gnomAD
CA410406250 rs1271381543	251	S>C		No	ClinGen gnomAD
CA410406246 rs1295397988	251	S>P		No	ClinGen TOPMed
CA410406260 rs201857663	253	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201857663 CA10049343	253	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10049345 rs201075773	254	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1361309654 CA410406269	254	G>V		No	ClinGen gnomAD
CA410406270 rs1222870470	255	E>K		No	ClinGen TOPMed gnomAD
CA10049346 rs200937759	256	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200937759 CA10049347	256	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs772909448 CA10049348	256	R>H		No	ClinGen ExAC TOPMed gnomAD
rs772909448 CA10049349	256	R>P		No	ClinGen ExAC TOPMed gnomAD
rs753827154 CA10049351	258	D>G		No	ClinGen ExAC gnomAD
rs766136307 CA10049350	258	D>N		No	ClinGen ExAC gnomAD
rs753827154 CA10049352	258	D>V		No	ClinGen ExAC gnomAD
rs752763619 CA10049354	259	A>T		No	ClinGen ExAC TOPMed gnomAD
rs771599434 CA10049355	259	A>V		No	ClinGen ExAC TOPMed gnomAD
rs912847502 CA321694470	261	S>F		No	ClinGen Ensembl
rs1163293124 CA410406307	262	Q>*		No	ClinGen gnomAD
rs1402925216 CA410406311	262	Q>H		No	ClinGen gnomAD
rs751810835 CA10049357	262	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA321694488 rs200385471	265	S>P		No	ClinGen 1000Genomes gnomAD
TCGA novel	266	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1326500428 CA410406342	267	K>E		No	ClinGen gnomAD
CA410406349 rs1429484844	268	P>A		No	ClinGen gnomAD
CA10049358 RCV000964089 rs58028593	268	P>L		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA10049359 rs58028593	268	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10049361 rs770281078	269	P>H		No	ClinGen ExAC TOPMed
rs770281078 CA410406355	269	P>L		No	ClinGen ExAC TOPMed
CA410406354 rs1601871499	269	P>S		No	ClinGen Ensembl
rs201622848 CA10049364	270	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10049363 rs201622848 COSM1264611	270	A>T	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs117749073 CA10049365	270	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs974733824 CA321698312	273	I>T		No	ClinGen TOPMed gnomAD
CA410406804 rs1222915966	274	C>Y		No	ClinGen TOPMed gnomAD
rs1481714467 CA410406822	277	E>K		No	ClinGen gnomAD
rs1481714467 CA410406823	277	E>Q		No	ClinGen gnomAD
rs1370054478 CA410406841	279	E>V		No	ClinGen TOPMed
CA410406848 rs1250225900	280	A>G		No	ClinGen gnomAD
rs544862341 CA10049394	281	G>D		No	ClinGen 1000Genomes ExAC gnomAD
CA10049396 rs750644934	285	A>T		No	ClinGen ExAC gnomAD
CA410406887 rs1480400593	286	G>D		No	ClinGen gnomAD
CA10049399 rs754431651	288	D>E		No	ClinGen ExAC gnomAD
rs766636330 CA10049398	288	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10049402 rs746471903	293	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10049404 rs563106945	294	P>R		No	ClinGen 1000Genomes ExAC gnomAD
rs756932112 CA10049403	294	P>S		No	ClinGen ExAC gnomAD
CA10049406 rs769697557	295	V>I		No	ClinGen ExAC gnomAD
rs772341923 CA10049432	299	D>N		No	ClinGen ExAC gnomAD
CA10049434 rs188937098	301	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1454278025 CA410407007	301	E>V		No	ClinGen gnomAD
CA10049436 rs777083793	303	V>F		No	ClinGen ExAC gnomAD
CA410407016 rs777083793	303	V>I		No	ClinGen ExAC gnomAD
rs990118066 CA321699003	304	A>G		No	ClinGen TOPMed gnomAD
CA410407036 rs879065863	306	R>I		No	ClinGen TOPMed gnomAD
rs879065863 CA410407037	306	R>K		No	ClinGen TOPMed gnomAD
CA321699007 rs879065863	306	R>T		No	ClinGen TOPMed gnomAD
rs1555890841 CA10049437	307	L>M		No	ClinGen Ensembl
CA321699033 rs914593381	308	F>C		No	ClinGen TOPMed
CA321699036 rs111865363	309	E>D		No	ClinGen TOPMed gnomAD
CA410407055 rs1318004786	309	E>G		No	ClinGen gnomAD
CA10049440 rs765573835	310	M>I		No	ClinGen ExAC gnomAD
CA410407059 rs1266907610	310	M>V		No	ClinGen gnomAD
rs753271460 CA10049441	311	A>S		No	ClinGen ExAC TOPMed gnomAD
rs753271460 CA410407066	311	A>T		No	ClinGen ExAC TOPMed gnomAD
rs373245016 CA10049442	313	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA410407081 rs1482729417	313	R>H		No	ClinGen TOPMed gnomAD
rs749855846 CA10049444	314	Q>P		No	ClinGen ExAC gnomAD
rs755826699 CA10049445	315	S>N		No	ClinGen ExAC gnomAD
CA10049447 rs753509960	316	T>A		No	ClinGen ExAC gnomAD
rs754874509 CA410407101	316	T>I		No	ClinGen ExAC gnomAD
CA10049448 rs754874509	316	T>S		No	ClinGen ExAC gnomAD
rs1337485584 CA410407102	317	P>T		No	ClinGen gnomAD
rs201861906 CA10049449	318	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs897562846 CA321699089	318	S>P		No	ClinGen Ensembl
CA410407119 rs1283767444	319	Q>H		No	ClinGen TOPMed
rs200706235 COSM1031185 CA10049451	323	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs200154081 CA10049452	323	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10049453 rs200154081	323	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1601873755 CA410407158	325	Y>C		No	ClinGen Ensembl
CA10049455 rs776765535	326	K>E		No	ClinGen ExAC gnomAD
CA10049456 rs915770 VAR_053895	326	K>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA321699117 rs1007775548	328	I>V		No	ClinGen gnomAD
rs1311204232 CA410407180	329	R>Q		No	ClinGen gnomAD
CA10049457 rs376330937 COSM444552	329	R>W	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	330	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA410407236 rs1269672252	336	G>R		No	ClinGen TOPMed
rs1333240205 CA410407257	337	G>V		No	ClinGen gnomAD
CA10049518 rs748501232	340	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA410407280 rs1444291128	341	E>K		No	ClinGen TOPMed gnomAD
rs772291941 CA10049519	342	D>G		No	ClinGen ExAC gnomAD
CA410407288 rs1288980387	342	D>N		No	ClinGen gnomAD
rs778472440 CA10049520	344	I>T		No	ClinGen ExAC gnomAD
rs1345917120 CA410407323	347	K>Q		No	ClinGen gnomAD
rs541555584 CA10049523	348	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10049526 rs768315459	351	R>C		No	ClinGen ExAC TOPMed gnomAD
CA410407352 rs768315459	351	R>G		No	ClinGen ExAC TOPMed gnomAD
CA10049527 rs559589580	351	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs767289804 CA10049529	354	E>G		No	ClinGen ExAC gnomAD
CA410407379 rs1364579576	356	R>G		No	ClinGen TOPMed
CA10049530 rs200137494	357	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs766457415 CA10049534	358	Q>H		No	ClinGen ExAC gnomAD
rs147437710 CA10049535	360	K>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA321700291 rs914649766	361	T>M		No	ClinGen Ensembl
CA410407420 rs1601875356	362	K>T		No	ClinGen Ensembl
CA10049539 rs752838989	363	K>N		No	ClinGen ExAC gnomAD
CA10049538 rs779233018	363	K>Q		No	ClinGen ExAC gnomAD
CA410407432 rs531133686	364	Q>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA410407436 rs1218891604	364	Q>H		No	ClinGen TOPMed
CA10049540 rs531133686	364	Q>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs745680911 CA10049542	365	K>N		No	ClinGen ExAC gnomAD
rs200910420 CA10049541	365	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA10049543 rs771516121	366	R>C		No	ClinGen ExAC gnomAD
rs772094375 CA10049544	366	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1202278717 CA410407457	368	L>P		No	ClinGen gnomAD
rs1268838161 CA410407459	369	R>G		No	ClinGen gnomAD
CA410407463 rs1208351864	369	R>S		No	ClinGen TOPMed
rs748871129 CA10049545	369	R>T		No	ClinGen ExAC gnomAD
rs201873899 CA10049546	370	L>W		No	ClinGen ExAC TOPMed gnomAD
CA410407487 rs1375497757	373	E>K		No	ClinGen gnomAD
TCGA novel	376	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs368644724 CA10049590	376	K>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs61737065 CA10049591	377	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1278822137 CA410407560	381	P>A		No	ClinGen TOPMed gnomAD
CA410407563 rs1311260260	381	P>L		No	ClinGen gnomAD
rs1278822137 CA410407561	381	P>S		No	ClinGen TOPMed gnomAD
rs1207712854 CA410407566	382	P>A		No	ClinGen gnomAD
rs563040118 CA10049592	382	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs530647149 CA10049594	384	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs530647149 CA410407586	384	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA321700949 rs113833203	384	P>S		No	ClinGen gnomAD
CA321700946 rs113833203	384	P>T		No	ClinGen gnomAD
rs1160289315 CA410407598	385	G>D		No	ClinGen TOPMed
rs1424642773 CA410407619	386	M>I		No	ClinGen TOPMed gnomAD
CA10049596 rs762063455	386	M>L		No	ClinGen ExAC gnomAD
CA321700964 rs767943393	387	E>*		No	ClinGen ExAC gnomAD
CA10049597 rs767943393	387	E>K		No	ClinGen ExAC gnomAD
rs1170851769 CA410407642	388	R>G		No	ClinGen gnomAD
CA10049598 rs750707803	389	K>R		No	ClinGen ExAC TOPMed gnomAD
CA10049599 rs756672405	390	R>T		No	ClinGen ExAC gnomAD
rs766831586 CA10049600	391	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1352137672 CA410407694	391	S>R		No	ClinGen gnomAD
rs1475248321 CA410407711	392	R>S		No	ClinGen TOPMed
rs754318876 CA10049601	393	R>K		No	ClinGen ExAC gnomAD
CA410407739 rs1274962807	394	R>S		No	ClinGen gnomAD
rs1366414497 CA410407761	396	V>I		No	ClinGen TOPMed gnomAD
rs1601876588 CA410407809	399	D>A		No	ClinGen Ensembl
rs1342688869 CA410407811	399	D>E		No	ClinGen gnomAD
rs1299503115 CA410407798	399	D>N		No	ClinGen TOPMed gnomAD
CA321700989 rs374983239	401	E>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA10049603 rs374983239	401	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA10049605 rs756802588	402	A>V		No	ClinGen ExAC TOPMed gnomAD
rs917493659 CA410407857	403	R>G		No	ClinGen gnomAD
CA321701000 rs371352025	403	R>Q		No	ClinGen ESP TOPMed gnomAD
COSM1161409 rs917493659 CA321700996	403	R>W	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
CA410407889 rs1167107922	405	E>D		No	ClinGen gnomAD
CA410407879 rs1449184773	405	E>Q		No	ClinGen gnomAD
CA321701003 rs1044545656	406	A>G		No	ClinGen TOPMed gnomAD
CA410407899 rs1044545656	406	A>V		No	ClinGen TOPMed gnomAD
rs1348830908 CA410407960	410	P>R		No	ClinGen gnomAD
rs1323616286 CA410407950	410	P>S		No	ClinGen gnomAD
rs769611441 CA410407969	411	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1167480277 CA410407962	411	G>S		No	ClinGen gnomAD
rs769611441 CA10049608	411	G>V		No	ClinGen ExAC TOPMed gnomAD
CA321701012 rs749405960	412	T>A		No	ClinGen Ensembl
rs374647783 CA10049609	412	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs771099338 CA321701018	413	A>G		No	ClinGen gnomAD
CA410407984 rs1365487257	413	A>T		No	ClinGen gnomAD
rs771099338 CA410407993	413	A>V		No	ClinGen gnomAD
CA321701022 rs1029595130	414	E>*		No	ClinGen TOPMed gnomAD
CA410407996 rs1029595130	414	E>K		No	ClinGen TOPMed gnomAD
CA10049610 rs749236769	415	R>G		No	ClinGen ExAC gnomAD
rs1436172220 CA410408016	415	R>Q		No	ClinGen TOPMed
CA410408014 rs749236769	415	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA410408022 rs1289237217	416	A>T		No	ClinGen gnomAD
CA321701026 rs774571978	416	A>V		No	ClinGen TOPMed gnomAD
CA410408034 rs889315095	417	L>V		No	ClinGen TOPMed gnomAD
CA321701032 rs759815874	418	L>H		No	ClinGen TOPMed gnomAD
rs61737064 CA10049612	419	R>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs372893290 CA321701035	419	R>Q		No	ClinGen ESP TOPMed gnomAD
rs1239634477 CA410408057	420	D>N		No	ClinGen gnomAD
rs1239634477 CA410408061	420	D>Y		No	ClinGen gnomAD
CA10049613 rs762121219	421	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA10049614 rs772142270	422	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1459360360 CA410408095	423	R>K		No	ClinGen gnomAD
TCGA novel	423	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA321701055 rs957955295	425	R>C		No	ClinGen TOPMed gnomAD
CA10049615 rs375793237 COSM1031186	425	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA410408108 rs375793237	425	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA410408110 rs1315925827	426	G>S		No	ClinGen gnomAD
CA410408125 rs1283469182	427	Q>R		No	ClinGen gnomAD
CA410408135 rs1353492753	428	R>K		No	ClinGen gnomAD
rs1457264068 CA410408165	430	A>V		No	ClinGen TOPMed
CA10049617 rs766713616	431	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs754408625 CA10049618	431	R>H		No	ClinGen ExAC gnomAD
rs1281158458 CA410408186	432	Q>R		No	ClinGen gnomAD
rs953802167 CA321701073	434	R>G		No	ClinGen TOPMed gnomAD
rs1255940180 CA410408225	435	R>K		No	ClinGen TOPMed gnomAD
rs1255940180 CA410408229	435	R>M		No	ClinGen TOPMed gnomAD
CA410408244 rs1473875036	437	P>S		No	ClinGen gnomAD
CA410408257 rs763607317	438	R>P		No	ClinGen ExAC TOPMed gnomAD
rs763607317 CA10049622	438	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA10049621 rs759967067	438	R>W		No	ClinGen ExAC TOPMed gnomAD
CA410408267 rs1442230822	440	L>V		No	ClinGen TOPMed
CA410408282 rs1403925942	441	T>N		No	ClinGen gnomAD
rs1032713187 CA321701082	443	A>D		No	ClinGen TOPMed gnomAD
rs1032713187 CA410408311	443	A>V		No	ClinGen TOPMed gnomAD
rs751020820 CA10049623	444	R>*		No	ClinGen ExAC TOPMed gnomAD
rs751020820 CA321701089	444	R>G		No	ClinGen ExAC TOPMed gnomAD
CA410408319 rs1353437225	444	R>Q		No	ClinGen gnomAD
TCGA novel	447	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10049624 rs756760981	447	A>V		No	ClinGen ExAC TOPMed gnomAD
rs780757767 CA10049625	448	A>T		No	ClinGen ExAC gnomAD
rs775964722 CA321701109	449	N>D		No	ClinGen TOPMed
rs1350018917 CA410408384	449	N>S		No	ClinGen TOPMed gnomAD
CA410408398 rs1276769452	450	V>I		No	ClinGen gnomAD
CA410408416 rs1345980727	451	Q>R		No	ClinGen gnomAD
rs755930249 CA10049627	453	P>A		No	ClinGen ExAC TOPMed gnomAD
rs749255086 CA10049629	453	P>L		No	ClinGen ExAC TOPMed gnomAD
rs755930249 CA10049628	453	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1206552467 CA410408471	454	E>D		No	ClinGen gnomAD
CA10049633 rs546622210	456	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1376681932 CA410408516	457	K>Q		No	ClinGen TOPMed
rs868547959 CA410408550	459	R>C		No	ClinGen TOPMed gnomAD
rs578093450 CA10049635 COSM1240107	459	R>H	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs578093450 CA10049634	459	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA321701134 rs868547959	459	R>S		No	ClinGen TOPMed gnomAD
CA10049637 rs760945245	461	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1376916644 CA410408574	462	E>C		No	ClinGen TOPMed

No associated diseases with P56182

No regional properties for P56182

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P56182

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
preribosome, large subunit precursor	A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.
preribosome, small subunit precursor	A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.

1 GO annotations of molecular function

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name	Definition
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P56183	Rrp1	Ribosomal RNA processing protein 1 homolog A	Mus musculus (Mouse)	PR
Q18674	rrp-1	Ribosomal RNA processing protein 1 homolog	Caenorhabditis elegans	PR

10	20	30	40	50	60
MVSRVQLPPE	IQLAQRLAGN	EQVTRDRAVR	KLRKYIVART	QRAAGGFTHD	ELLKVWKGLF
70	80	90	100	110	120
YCMWMQDKPL	LQEELGRTIS	QLVHAFQTTE	AQHLFLQAFW	QTMNREWTGI	DRLRLDKFYM
130	140	150	160	170	180
LMRMVLNESL	KVLKMQGWEE	RQIEELLELL	MTEILHPSSQ	APNGVKSHFI	EIFLEELTKV
190	200	210	220	230	240
GAEELTADQN	LKFIDPFCRI	AARTKDSLVL	NNITRGIFET	IVEQAPLAIE	DLLNELDTQD
250	260	270	280	290	300
EEVASDSDES	SEGGERGDAL	SQKRSEKPPA	GSICRAEPEA	GEEQAGDDRD	SGGPVLQFDY
310	320	330	340	350	360
EAVANRLFEM	ASRQSTPSQN	RKRLYKVIRK	LQDLAGGIFP	EDEIPEKACR	RLLEGRRQKK
370	380	390	400	410	420
TKKQKRLLRL	QQERGKGEKE	PPSPGMERKR	SRRRGVGADP	EARAEAGEQP	GTAERALLRD
430	440	450	460
QPRGRGQRGA	RQRRRTPRPL	TSARAKAANV	QEPEKKKKRR	E