P53745

PR
Gene name
MNT4 (YNR059W, N3514)
Protein name
Probable alpha-1,3-mannosyltransferase MNT4
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YNR059W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P53745

Entry ID Method Resolution Chain Position Source
AF-P53745-F1 Predicted AlphaFoldDB

13 variants for P53745

Variant ID(s) Position Change Description Diseaes Association Provenance
s14-736873 24 V>G No SGRP
s14-736950 50 V>L No SGRP
s14-737061 87 S>G No SGRP
s14-737202 134 T>A No SGRP
s14-737271 157 R>S No SGRP
s14-737420 206 E>D No SGRP
s14-737670 290 F>L No SGRP
s14-737975 391 D>E No SGRP
s14-738000 400 Q>K No SGRP
s14-738132 444 I>V No SGRP
s14-738340 513 R>Q No SGRP
s14-738436 545 S>N No SGRP
s14-738473 557 K>N No SGRP

No associated diseases with P53745

No regional properties for P53745

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P53745

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
alpha-1,3-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.

1 GO annotations of biological process

Name Definition
protein O-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53059 MNT2 Alpha-1,3-mannosyltransferase MNT2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MVLRIRRIKK LAPLIFTSLL SLIVLFRVYR QYPFSDHFET RREDDRSGNV HCFSRLRQIE
70 80 90 100 110 120
EYEKPELTSK FYEPNRWKSF ISYVTRSRKD VKTVSRSLSN LDLYQKCSKE IRADQDISLL
130 140 150 160 170 180
HSIETKLFPY INFTALNSEQ SHNFWPVHTR FDGTKYRGQV LQFSSENNSF IGTSPIEFKA
190 200 210 220 230 240
SEPFWENWLN SALQRNSKGV VMSVSEYLVA DTIRLIRVLR LLNNSLPIEI VHKSDLHESS
250 260 270 280 290 300
QQLLIAAARE SGSLNYPPQE LWFLDVKDML NDEYLARFKR FSNKWLAITF CSFQIPIFLD
310 320 330 340 350 360
SDTVPFVPLD TLYEIDGFKR TGTLFFKDRS FPTSKLSPLQ VKVLKQIINN SLDVSSDSEQ
370 380 390 400 410 420
GFEILKHNLN DEMAIDAIEA LIFKKQKHYM DSGLVIFDKQ KHFFCLPIAI MLQFSPIQEF
430 440 450 460 470 480
FHGDKEWFWL SLFISKKEFT FYPIEASNVG RLEKPETLES STICSTQLSH TDVYGNLLWL
490 500 510 520 530 540
NGGLSVCKKN CWNYDFTKRK EIAAKYKSVD ELRNYYQSPV KLEAVIIPDV SKSPWSQQSE
550 560 570
CVMYSYCTHY RKGQYGKLIE FTDSQKKYYE KVVELWNKVV