P53059
Gene name |
MNT2 (YGL257C, NRD558) |
Protein name |
Alpha-1,3-mannosyltransferase MNT2 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGL257C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53059
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53059-F1 | Predicted | AlphaFoldDB |
16 variants for P53059
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-13971 | 63 | N>D | No | SGRP | |
| s07-13809 | 117 | D>N | No | SGRP | |
| s07-13749 | 137 | M>V | No | SGRP | |
| s07-13652 | 169 | V>A | No | SGRP | |
| s07-13470 | 230 | T>A | No | SGRP | |
| s07-13343 | 272 | I>T | No | SGRP | |
| s07-13299 | 287 | E>K | No | SGRP | |
| s07-13281 | 293 | E>K | No | SGRP | |
| s07-13203 | 319 | K>E | No | SGRP | |
| s07-13185 | 325 | V>I | No | SGRP | |
| s07-13050 | 370 | I>V | No | SGRP | |
| s07-12884 | 425 | Q>R | No | SGRP | |
| s07-12857 | 434 | S>N | No | SGRP | |
| s07-12756 | 468 | T>A | No | SGRP | |
| s07-12663 | 499 | K>E | No | SGRP | |
| s07-12524 | 545 | L>H | No | SGRP |
No associated diseases with P53059
No regional properties for P53059
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P53059 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| alpha-1,3-mannosyltransferase activity | Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein O-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P53745 | MNT4 | Probable alpha-1,3-mannosyltransferase MNT4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRRKNRLFIL | VVLLGIVLVV | YYSQLNSLDL | VEPVQSSSSG | NGGCWSYYEG | LTPGWLNDFY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DVNQITPNPA | KDVIELVTRI | KIFFNCLQQV | DGHNIQRLRD | IEKKLFPYIN | FEKLETDESA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FWHTTTRWNG | EVYHASMLEF | DPKNHQFLRS | KPINFDTGLS | FWENWLHTVT | QSGSKGIVIS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ASDVQLNETI | RLLKVLRFIK | NDYPIQIVHN | ADLSQDSMKS | IIKYARSLDT | AEYPAQELWF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LNVHSLLNPK | YSKKFTTYSN | KWLALTFSSF | EIPILMDSDT | VPFVSIEKFY | ELEEFQKTGV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFFKDRVISD | DLFESSELKI | LREIVYGCIG | LDLEDESKIH | EQVEDPVVAQ | VLENMFIKKY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KHHLESGLVI | LHKGKHLFSM | LTSIALQFSP | IAEYFHGDKD | FFWLGELLSN | NRFTFHPVDA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SNIGQLGNVV | SKESTGEFYQ | ICSVQLSHTD | RDGSLLWLNG | GLNICKKTSW | EYDYEHRQRL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NDMFQNADEL | REYYASPVKL | EGIIIPDTSI | SGWINSGECF | LFNYCTLFKE | GEFGKLIKFK |
| 550 | |||||
| EDEKLRLSQI | VDIWNKDI |