P53241
Gene name |
VHT1 (YGR065C) |
Protein name |
Vitamin H transporter |
Names |
H(+)/biotin symporter |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR065C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53241
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53241-F1 | Predicted | AlphaFoldDB |
13 variants for P53241
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-619802 | 21 | D>H | No | SGRP | |
| s07-619792 | 24 | Y>S | No | SGRP | |
| s07-619781 | 28 | D>N | No | SGRP | |
| s07-619717 | 49 | K>R | No | SGRP | |
| s07-619672 | 64 | H>R | No | SGRP | |
| s07-619669 | 65 | N>S | No | SGRP | |
| s07-619631 | 78 | A>T | No | SGRP | |
| s07-619342 | 174 | N>S | No | SGRP | |
| s07-618950 | 305 | A>T | No | SGRP | |
| s07-618947 | 306 | I>L | No | SGRP | |
| s07-618590 | 425 | G>S | No | SGRP | |
| s07-618128 | 579 | N>D | No | SGRP | |
| s07-618106 | 586 | Y>F | No | SGRP |
No associated diseases with P53241
No regional properties for P53241
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P53241 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell periphery | The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| intrinsic component of membrane | The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| biotin transmembrane transporter activity | Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. |
| symporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. |
| transmembrane transporter activity | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| biotin transport | The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P40445 | YIL166C | Uncharacterized transporter YIL166C | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTISNKSWRS | YFPHLRKLPE | DDQYLYSDDT | NSSIIAEEEL | HHSVDKSSKT | DVTAETTAVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PHPHNLRHDL | PYEVRDEAGR | KWWKYFDEFE | YRVNKEYKKS | RKWYEFLYPN | HTTQTKAERR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLYKLDIIIA | LYFFMLCWSK | SVDLNNYTNA | YVSNMKEDLN | MKGNDYVYTS | TIANVGAIVF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QLPFMYLLPR | FPSHIILPVM | DLGWTWFTFA | CYRANSLAEL | RAYRFILSAF | GAAYYPVSQY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILGCWYAPDE | INSRVCLFFC | GQQLGSVTSG | LLQSRIFKSL | NGVHGLAGWR | WMFLIDAIAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SLPTAIIGFF | VIPGVPSKCY | SLFLTDEEIR | IARARNKRNQ | IKDGVDKSKL | APLWSRKLWK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KVFCTPAFWV | LVVFDTCSWN | NMTAYSGSYT | LWLKSNTKYS | IAQVNNLSVI | PACLGFAYVI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FCAFGADLFR | CKWIFMVFAA | IMNTVSCALL | IKWDIPSKAK | WYAFFTTYFS | VAASPCLWSF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| INDFLRFDPQ | VKAITWIAIY | SFSQSTYAWI | PTLAWPTVES | PRFKTGYTVS | LIFGAIYGLW |
| 550 | 560 | 570 | 580 | 590 | |
| TFVVLFFYKR | NEKKHALGNG | IILYDSNKGE | ELPEFVKKNM | EERDGYYYLK | RSS |