P40445

PR
Gene name
YIL166C
Protein name
Uncharacterized transporter YIL166C
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YIL166C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-84 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P40445

Entry ID Method Resolution Chain Position Source
AF-P40445-F1 Predicted AlphaFoldDB

4 variants for P40445

Variant ID(s) Position Change Description Diseaes Association Provenance
s09-32347 74 V>I No SGRP
s09-32320 83 L>M No SGRP
s09-32295 91 F>Y No SGRP
s09-31519 350 S>R No SGRP

No associated diseases with P40445

1 regional properties for P40445

Type Name Position InterPro Accession
domain Major facilitator superfamily domain 82 - 509 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
fungal-type vacuole A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intrinsic component of membrane The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.

3 GO annotations of molecular function

Name Definition
sulfate transmembrane transporter activity Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.
sulfur compound transmembrane transporter activity Enables the transfer of a sulfur compound from one side of a membrane to the other.
transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

3 GO annotations of biological process

Name Definition
sulfate transport The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
sulfite transport The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
sulfur compound transport The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53241 VHT1 Vitamin H transporter Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MSVQKEEYDI VEKAQLSVSA ESLTSDSESI SHNPFDDFHK AERWRKVYES SGYEGLSKFD
70 80 90 100 110 120
PEFTWTKDEE KKLVRKMDLK IFLWVFIMFA FLDLIRKNIA RAVSDNFIVD LKMNTNDYNL
130 140 150 160 170 180
GQTVYLVIFL ASELPGNLLS KRFGPERVIP VQIVLWSVIC ITQAGLKNRG QFIATRCLLG
190 200 210 220 230 240
MVQGGFIPDN ILYLSYYYTG AELTFRLSFF WCAIPLFQIL GSLLASGIIE MRGIHNLAGW
250 260 270 280 290 300
QYLFIIEGFL SLSVGVASFY LMRRGPTQTG ESAFHKGKSL FTEYEEKIMV NRILRDDPSK
310 320 330 340 350 360
GDMSNRQPVT FKEILYTLTE FDLWPLFIQG ITAFISLQTV GSYLSLILKS LNYSTFLSNI
370 380 390 400 410 420
LAIPGQALLL INLPLAALLS RKLKEKSLCV GIANVWVLPF IVSLVALPTD TNPWIKYILL
430 440 450 460 470 480
TGILGLPYTH SILAGWVSEI SNSVRSRTVG TALYNMSAQV GAIIASNMYR NDDKPYYTRG
490 500 510 520 530 540
NKILLGFTCF NICMAVATKF YYISRNKYKD RKWNSMTKEE QINYLDTTKD KGMKRLDYRF
IH