P53237
Gene name |
LST7 (YGR057C) |
Protein name |
Protein LST7 |
Names |
Lethal with SEC thirteen protein 7 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR057C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53237
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53237-F1 | Predicted | AlphaFoldDB |
5 variants for P53237
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-605495 | 4 | T>I | strain: SK1 [UniProt] | No | SGRP |
| s07-605450 | 19 | I>T | No | SGRP | |
| s07-604980 | 176 | F>L | No | SGRP | |
| s07-604971 | 179 | K>E | No | SGRP | |
| s07-604881 | 209 | R>C | No | SGRP |
No associated diseases with P53237
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| FNIP-folliculin RagC/D GAP | A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains follicular (FLCN) and either follicular interacting protein 1 (FNIP1) or FNIP2. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of GTPase activity | Any process that activates or increases the activity of a GTPase. |
| positive regulation of TORC1 signaling | Any process that activates or increases the frequency, rate or extent of TORC1 signaling. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3B7L5 | FLCN | Folliculin | Bos taurus (Bovine) | PR |
| Q8NFG4 | FLCN | Folliculin | Homo sapiens (Human) | PR |
| Q8QZS3 | Flcn | Folliculin | Mus musculus (Mouse) | PR |
| Q76JQ2 | Flcn | Folliculin | Rattus norvegicus (Rat) | PR |
| Q5M7Q1 | flcn | Folliculin | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSTVISLAH | FCDKHGPRII | SVTQSAEKGT | LGEELLVPDY | PTESYCESCL | LQFPEESTRS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MRCFIEDVPF | ITTQYSSIRY | QLLNSIIKRA | FSEETMIYDN | MPFIFFDDLR | GLNLVIGFKL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YDENARGNER | RYCFILTVDS | RSHDDSMKML | SEHWNFIIGG | FDKMIAYIKN | IHKSEFLGKN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KTVENNLETL | NNNAFIGSYL | RANKSKFGRN | LVSLTDDKFL | FVRIHKWNSF | LLHTVMNENK |
| LP |