P51655
PR
Gene name |
Gpc4 |
Protein name |
Glypican-4 |
Names |
K-glypican |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:14735 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51655
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51655-F1 | Predicted | AlphaFoldDB |
42 variants for P51655
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389526554 | 55 | D>G | No | EVA | |
| rs3389563981 | 70 | E>G | No | EVA | |
| rs3389552942 | 85 | T>S | No | EVA | |
| rs3389560746 | 91 | C>F | No | EVA | |
| rs248774290 | 96 | A>S | No | EVA | |
| rs3389552856 | 100 | S>C | No | EVA | |
| rs3408026880 | 110 | K>KFFEEF* | No | EVA | |
| rs3389560788 | 143 | F>V | No | EVA | |
| rs3410097494 | 148 | R>P | No | EVA | |
| rs3389558827 | 149 | Y>F | No | EVA | |
| rs3389555466 | 151 | V>SDG* | No | EVA | |
| rs3389574232 | 152 | A>V | No | EVA | |
| rs30328120 | 154 | N>K | No | EVA | |
| rs3389552917 | 155 | V>G | No | EVA | |
| rs3389568878 | 158 | E>V | No | EVA | |
| rs3389553424 | 200 | F>I | No | EVA | |
| rs3389526591 | 229 | R>G | No | EVA | |
| rs3389558835 | 265 | P>S | No | EVA | |
| rs3389552892 | 266 | C>R | No | EVA | |
| rs3389555495 | 268 | N>K | No | EVA | |
| rs3410206056 | 269 | Y>YSKSRSPWLAKQPRMMFEQ* | No | EVA | |
| rs3389508311 | 339 | Q>H | No | EVA | |
| rs3389538901 | 385 | L>M | No | EVA | |
| rs3389538878 | 394 | K>E | No | EVA | |
| rs3389526570 | 406 | T>I | No | EVA | |
| rs3389558836 | 408 | C>R | No | EVA | |
| rs3409044521 | 413 | M>I | No | EVA | |
| rs3408025525 | 416 | G>V | No | EVA | |
| rs3409823304 | 422 | D>A | No | EVA | |
| rs3410249556 | 422 | D>Y | No | EVA | |
| rs3389560197 | 450 | V>A | No | EVA | |
| rs3409044493 | 451 | Q>* | No | EVA | |
| rs3389526568 | 455 | S>T | No | EVA | |
| rs3389555524 | 477 | N>K | No | EVA | |
| rs3389560224 | 507 | C>S | No | EVA | |
| rs31381097 | 537 | A>T | No | EVA | |
| rs3409044547 | 546 | C>S | No | EVA | |
| rs3410456329 | 551 | A>P | No | EVA | |
| rs3410349135 | 552 | V>A | No | EVA | |
| rs3389568875 | 552 | V>M | No | EVA | |
| rs3410200120 | 554 | G>R | No | EVA | |
| rs3389560255 | 557 | R>K | No | EVA |
No associated diseases with P51655
1 regional properties for P51655
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Glypican, conserved site | 254 - 277 | IPR019803 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchored component of presynaptic membrane | The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| external side of plasma membrane | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| Golgi lumen | The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane. |
| regulation of presynapse assembly | Any process that modulates the frequency, rate or extent of presynapse assembly. |
| regulation of protein localization to membrane | Any process that modulates the frequency, rate or extent of protein localization to membrane. |
| regulation of signal transduction | Any process that modulates the frequency, rate or extent of signal transduction. |
| synaptic membrane adhesion | The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARLGLLALL | CTLAALSASL | LAAELKSKSC | SEVRRLYVSK | GFNKNDAPLY | EINGDHLKIC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PQDYTCCSQE | MEEKYSLQSK | DDFKTVVSEQ | CNHLQAIFAS | RYKKFDEFFK | ELLENAEKSL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NDMFVKTYGH | LYMQNSELFK | DLFVELKRYY | VAGNVNLEEM | LNDFWARLLE | RMFRLVNSQY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HFTDEYLECV | SKYTEQLKPF | GDVPRKLKLQ | VTRAFVAART | FAQGLAVARD | VVSKVSVVNP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TAQCTHALLK | MIYCSHCRGL | VTVKPCYNYC | SNIMRGCLAN | QGDLDFEWNN | FIDAMLMVAE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RLEGPFNIES | VMDPIDVKIS | DAIMNMQDNS | VQVSQKVFQG | CGPPKPLPAG | RISRSISESA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FSARFRPYHP | EQRPTTAAGT | SLDRLVTDVK | EKLKQAKKFW | SSLPSTVCND | ERMAAGNENE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DDCWNGKGKS | RYLFAVTGNG | LANQGNNPEV | QVDTSKPDIL | ILRQIMALRV | MTSKMKNAYN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GNDVDFFDIS | DESSGEGSGS | GCEYQQCPSE | FEYNATDHSG | KSANEKADSA | GGAHAEAKPY |
| 550 | |||||
| LLAALCILFL | AVQGEWR |