AiPD: Autoinhibited Protein Database

P50914

Gene name	RPL14
Protein name	60S ribosomal protein L14
Names	CAG-ISL 7, Large ribosomal subunit protein eL14
Species	Homo sapiens (Human)
KEGG Pathway	hsa:9045
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

111-180 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

111-180 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

93 structures for P50914

Entry ID	Method	Resolution	Chain	Position	Source
4UG0	EM	-	LM	1-215	PDB
4V6X	EM	500 A	CM	1-215	PDB
5AJ0	EM	350 A	AM	1-215	PDB
5LKS	EM	360 A	LM	1-215	PDB
5T2C	EM	360 A	s	1-215	PDB
6IP5	EM	390 A	2G	1-215	PDB
6IP6	EM	450 A	2G	1-215	PDB
6IP8	EM	390 A	2G	1-215	PDB
6LQM	EM	309 A	S	1-215	PDB
6LSR	EM	313 A	S	1-215	PDB
6LSS	EM	323 A	S	1-215	PDB
6LU8	EM	313 A	S	1-215	PDB
6OLE	EM	310 A	N	2-140	PDB
6OLF	EM	390 A	N	2-140	PDB
6OLG	EM	340 A	AM	2-140	PDB
6OLI	EM	350 A	N	2-140	PDB
6OLZ	EM	390 A	AM	2-140	PDB
6OM0	EM	310 A	N	2-140	PDB
6OM7	EM	370 A	N	2-140	PDB
6QZP	EM	290 A	LM	2-140	PDB
6W6L	EM	384 A	N	1-215	PDB
6XA1	EM	280 A	LM	2-140	PDB
6Y0G	EM	320 A	LM	1-215	PDB
6Y2L	EM	300 A	LM	1-215	PDB
6Y57	EM	350 A	LM	1-215	PDB
6Y6X	EM	280 A	LM	2-140	PDB
6Z6L	EM	300 A	LM	1-215	PDB
6Z6M	EM	310 A	LM	1-215	PDB
6Z6N	EM	290 A	LM	1-215	PDB
6ZM7	EM	270 A	LM	1-215	PDB
6ZME	EM	300 A	LM	1-215	PDB
6ZMI	EM	260 A	LM	1-215	PDB
6ZMO	EM	310 A	LM	1-215	PDB
7BHP	EM	330 A	LM	1-215	PDB
7F5S	EM	272 A	LM	1-215	PDB
7QVP	EM	300 A	LM/MM	1-215	PDB
7XNX	EM	270 A	LM	1-215	PDB
7XNY	EM	250 A	LM	1-215	PDB
8FKP	EM	285 A	L8	1-215	PDB
8FKQ	EM	276 A	L8	1-215	PDB
8FKR	EM	289 A	L8	1-215	PDB
8FKS	EM	288 A	L8	1-215	PDB
8FKT	EM	281 A	L8	1-215	PDB
8FKU	EM	282 A	L8	1-215	PDB
8FKV	EM	247 A	L8	1-215	PDB
8FKW	EM	250 A	L8	1-215	PDB
8FKX	EM	259 A	L8	1-215	PDB
8FKY	EM	267 A	L8	1-215	PDB
8FKZ	EM	304 A	L8	1-215	PDB
8FL0	EM	291 A	L8	1-215	PDB
8FL2	EM	267 A	L8	1-215	PDB
8FL3	EM	253 A	L8	1-215	PDB
8FL4	EM	289 A	L8	1-215	PDB
8FL6	EM	262 A	L8	1-215	PDB
8FL7	EM	255 A	L8	1-215	PDB
8FL9	EM	275 A	L8	1-215	PDB
8FLA	EM	263 A	L8	1-215	PDB
8FLB	EM	255 A	L8	1-215	PDB
8FLC	EM	276 A	L8	1-215	PDB
8FLD	EM	258 A	L8	1-215	PDB
8FLE	EM	248 A	L8	1-215	PDB
8FLF	EM	265 A	L8	1-215	PDB
8G5Y	EM	229 A	LM	1-215	PDB
8G5Z	EM	264 A	LM	2-137	PDB
8G60	EM	254 A	LM	1-215	PDB
8G61	EM	294 A	LM	1-215	PDB
8G6J	EM	280 A	LM	1-215	PDB
8GLP	EM	167 A	LM	1-215	PDB
8IDT	EM	280 A	S	1-215	PDB
8IDY	EM	300 A	S	1-215	PDB
8IE3	EM	330 A	S	1-215	PDB
8IFD	EM	259 A	2G	1-215	PDB
8IFE	EM	257 A	2G	1-215	PDB
8INE	EM	320 A	S	1-215	PDB
8INF	EM	300 A	S	1-215	PDB
8INK	EM	320 A	S	1-215	PDB
8IPD	EM	320 A	S	1-215	PDB
8IPX	EM	430 A	S	1-215	PDB
8IPY	EM	320 A	S	1-215	PDB
8IR1	EM	330 A	S	1-215	PDB
8IR3	EM	350 A	S	1-215	PDB
8JDJ	EM	250 A	R	1-215	PDB
8JDK	EM	226 A	R	1-215	PDB
8JDL	EM	242 A	R	1-215	PDB
8JDM	EM	267 A	R	1-215	PDB
8OHD	EM	310 A	LM	1-215	PDB
8OJ0	EM	330 A	LM	1-215	PDB
8OJ5	EM	290 A	LM	1-215	PDB
8OJ8	EM	330 A	LM	1-215	PDB
8QFD	EM	220 A	M	1-215	PDB
8Y0W	EM	340 A	LM	1-215	PDB
8Y0X	EM	330 A	LM	1-215	PDB
AF-P50914-F1	Predicted				AlphaFoldDB

194 variants for P50914

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA74061458 rs896479078	2	V>A		No	ClinGen Ensembl
rs766209314 CA2329603	3	F>L		No	ClinGen ExAC gnomAD
CA2329604 rs751439262	7	V>M		No	ClinGen ExAC gnomAD
CA352220585 rs1471096502	9	V>L		No	ClinGen gnomAD
rs1559527864 CA352220624	13	A>S		No	ClinGen Ensembl
rs181009417 CA2329606	13	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs757289887 CA2329608	14	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs753832297 CA2329607	14	Y>H		No	ClinGen ExAC gnomAD
CA352220636 rs757289887	14	Y>S		No	ClinGen ExAC TOPMed gnomAD
rs1337582378 CA352220669	17	F>C		No	ClinGen TOPMed gnomAD
CA2329609 rs778989689	17	F>L		No	ClinGen ExAC TOPMed gnomAD
CA352220694 rs1443624022	19	P>R		No	ClinGen gnomAD
rs1243676252 CA352220692	19	P>S		No	ClinGen gnomAD
CA2329610 rs373097776	20	H>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs373097776 CA2329611	20	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1315291727 CA352220704	21	A>T		No	ClinGen gnomAD
rs1199642839 CA352220716	22	G>R		No	ClinGen TOPMed
CA2329612 rs35187187	23	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2329615 rs781694922	26	A>T		No	ClinGen ExAC TOPMed gnomAD
rs549220896 CA2329616	26	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs772853082 CA2329618	28	V>L		No	ClinGen ExAC gnomAD
rs139543259 CA2329619	33	Q>E		No	ClinGen ESP ExAC gnomAD
CA2329620 rs770765769	34	N>Y		No	ClinGen ExAC gnomAD
CA2329621 rs773997383	35	R>W		No	ClinGen ExAC gnomAD
CA2329639 rs759136177	36	A>G		No	ClinGen ExAC gnomAD
rs1405880407 CA352221243	39	D>N		No	ClinGen gnomAD
CA2329641 rs139084909	43	T>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2329642 rs760604858	44	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1269122358 CA352221372	48	Q>H		No	ClinGen gnomAD
CA352221368 rs1227565422	48	Q>R		No	ClinGen gnomAD
rs750467711 CA2329644	49	A>P		No	ClinGen ExAC gnomAD
rs1263677466 CA352221409	50	M>I		No	ClinGen gnomAD
rs1460709153 CA352221431	51	P>S		No	ClinGen gnomAD
TCGA novel	52	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2329646 rs766390630	54	C>R		No	ClinGen ExAC gnomAD
rs370139545 CA2329647	55	M>L		No	ClinGen ESP ExAC gnomAD
rs370139545 CA2329648	55	M>V		No	ClinGen ESP ExAC gnomAD
rs758026307 CA2329649	58	T>I		No	ClinGen ExAC gnomAD
CA352221571 rs1481450301	60	F>V		No	ClinGen gnomAD
rs1049286296 CA74062210	62	L>V		No	ClinGen TOPMed
rs756667393 CA2329651	64	F>C		No	ClinGen ExAC gnomAD
rs778466178 CA352221653	64	F>L		No	ClinGen ExAC gnomAD
rs1171313476 CA352221674	65	P>L		No	ClinGen TOPMed gnomAD
rs1171313476 CA352221664	65	P>R		No	ClinGen TOPMed gnomAD
rs774468497 CA2329685	67	S>R		No	ClinGen ExAC TOPMed gnomAD
CA2329686 rs759575752	69	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA352222027 rs1575251793	73	V>A		No	ClinGen Ensembl
CA74065018 rs1056263013	74	R>G		No	ClinGen Ensembl
rs767738336 CA2329687	74	R>Q		No	ClinGen ExAC gnomAD
CA352222041 rs775806582	76	A>S		No	ClinGen ExAC gnomAD
CA2329688 COSM1422977 rs775806582	76	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1378130952 CA352222042	76	A>V		No	ClinGen gnomAD
rs1802712 CA74065035	77	W>R		No	ClinGen Ensembl
rs752863815 CA2329689	78	Q>R		No	ClinGen ExAC gnomAD
CA74065043 rs897621513	81	D>A		No	ClinGen TOPMed gnomAD
rs764489393 CA74065045	82	I>M		No	ClinGen ExAC gnomAD
CA352222088 rs1382880576	83	N>D		No	ClinGen TOPMed
rs570995505 CA352222091	83	N>I		No	ClinGen ExAC TOPMed gnomAD
rs570995505 CA2329691	83	N>S		No	ClinGen ExAC TOPMed gnomAD
rs145433390 CA2329692	84	T>I		No	ClinGen ESP ExAC gnomAD
rs1397047823 CA352222103	85	K>R		No	ClinGen gnomAD
CA352222109 rs1575251818	86	W>G		No	ClinGen Ensembl
rs750968462 CA2329694	89	T>A		No	ClinGen ExAC gnomAD
CA352222155 rs1314630207	93	K>Q		No	ClinGen gnomAD
CA352222170 rs1320005499	95	I>V		No	ClinGen gnomAD
CA74065078 rs887717883	97	A>G		No	ClinGen Ensembl
rs1252429914 CA352222192	97	A>T		No	ClinGen gnomAD
CA2329695 rs757793884	99	E>G		No	ClinGen ExAC gnomAD
rs1420209939 CA352222212	99	E>K		No	ClinGen TOPMed
rs1420942437 CA352222225	100	R>G		No	ClinGen gnomAD
CA2329715 rs765652396	102	A>T		No	ClinGen ExAC gnomAD
rs1477209695 CA352222309	103	K>E		No	ClinGen TOPMed gnomAD
CA352222321 rs1168456645	104	M>V		No	ClinGen TOPMed gnomAD
CA2329716 rs750834399	109	R>C		No	ClinGen ExAC TOPMed gnomAD
rs750834399 CA352222387	109	R>S		No	ClinGen ExAC TOPMed gnomAD
rs763452545 CA2329717	111	K>T		No	ClinGen ExAC
rs765868400 CA2329718	113	M>T		No	ClinGen ExAC gnomAD
rs1298488348 CA352222450	115	A>T		No	ClinGen gnomAD
CA74065283 rs11539050	115	A>V		No	ClinGen Ensembl
CA74065625 rs756107625	119	R>S		No	ClinGen gnomAD
rs145518013 CA74065663	121	R>S		No	ClinGen Ensembl
rs763794487 CA2329743	121	R>T		No	ClinGen ExAC TOPMed gnomAD
rs1235486538 CA352222594	122	I>V		No	ClinGen TOPMed
CA352222646 rs1354142115	125	N>S		No	ClinGen TOPMed
rs11539060 CA74065673	126	E>G		No	ClinGen Ensembl
rs1198157102 CA352222679	128	K>E		No	ClinGen gnomAD
rs753746678 CA2329744	128	K>T		No	ClinGen ExAC gnomAD
rs11539059 CA74065701	129	K>*		No	ClinGen Ensembl
CA352222723 rs1471046847	132	K>Q		No	ClinGen gnomAD
CA352222747 rs1177516316	134	A>P		No	ClinGen gnomAD
rs145682545 CA2329745	135	L>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA74065715 rs919020732	137	K>N		No	ClinGen TOPMed gnomAD
VAR_013633 rs929099541 CA74065719	138	A>S		No	ClinGen UniProt TOPMed dbSNP
rs779038374 CA2329746	139	S>A		No	ClinGen ExAC TOPMed gnomAD
CA352222801 rs745818038	140	P>A		No	ClinGen ExAC gnomAD
rs745818038 CA2329747	140	P>S		No	ClinGen ExAC gnomAD
CA2329748 rs755047019	141	K>R		No	ClinGen ExAC gnomAD
rs781334217 CA2329749	142	K>N		No	ClinGen ExAC gnomAD
rs1413983573 CA352222830	143	A>T		No	ClinGen TOPMed
CA74065765 rs891467645	143	A>V		No	ClinGen TOPMed gnomAD
CA2329750 rs148931839	144	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1474074392 CA352222842	144	P>S		No	ClinGen TOPMed
CA352222856 rs1316713036	145	G>A		No	ClinGen gnomAD
rs1237585591 CA352222849	145	G>R		No	ClinGen gnomAD
rs770111063 CA2329751	146	T>S		No	ClinGen ExAC gnomAD
CA352222875 rs1202180936	147	K>N		No	ClinGen TOPMed gnomAD
rs1208666900 CA352222877	148	G>S		No	ClinGen gnomAD
CA74065808 rs199894150	148	G>V		No	ClinGen TOPMed
rs200018880 CA74065874	149	T>A		No	ClinGen TOPMed
CA352222910 rs1429262856	150	A>T		No	ClinGen TOPMed
CA74065924 rs201325213	151	A>G		No	ClinGen Ensembl
CA352222941 rs773425371	152	A>D		No	ClinGen ExAC gnomAD
CA2329764 COSM1663965 rs773425371	152	A>G	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs201931132 CA74065976	152	A>T		No	ClinGen Ensembl
TCGA novel	153	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA352222945 rs749693566	153	A>S		No	ClinGen ExAC gnomAD
COSM1663966 CA2329765 rs749693566	153	A>T	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs57354599 RCV000949259	154	A>missing		No	ClinVar dbSNP
rs1252565022 CA352222972	154	A>V		No	ClinGen TOPMed
RCV000949258 rs57354599	155	A>missing		No	ClinVar dbSNP
CA74065997 rs899792463	155	A>S		No	ClinGen Ensembl
VAR_047109	158	A>del		No	UniProt
VAR_013634	159	A>AA		No	UniProt
VAR_014070	159	A>AAA		No	UniProt
VAR_013635	159	A>AAAA		No	UniProt
VAR_013636	159	A>AAAAA		No	UniProt
VAR_006923	159	A>AAAAAA		No	UniProt
VAR_013637	159	A>AAAAAAAA		No	UniProt
CA352223027 rs1231712234	159	A>V		No	ClinGen TOPMed
CA2329775 rs200879671	160	K>E		No	ClinGen ExAC TOPMed gnomAD
rs760050779 CA2329777	160	K>N		No	ClinGen ExAC
CA2329776 rs774792368	160	K>T		No	ClinGen ExAC gnomAD
CA2329778 rs766872722	161	V>A		No	ClinGen ExAC
CA2329779 rs775134576	162	P>A		No	ClinGen ExAC gnomAD
rs763859368 CA2329781	165	K>N		No	ClinGen ExAC gnomAD
rs1243470255	166	I>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA2329782 rs753658672	166	I>M		No	ClinGen ExAC TOPMed gnomAD
CA352223105 rs1281849082	167	T>A		No	ClinGen TOPMed
rs1281849082 CA352223109	167	T>P		No	ClinGen TOPMed
CA2329784 rs375865018	168	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs750315795 CA2329785	168	A>V		No	ClinGen ExAC gnomAD
rs148088669 CA2329787	169	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs141817449 CA2329788	169	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA74066146 rs1025622363	170	S>N		No	ClinGen TOPMed gnomAD
CA74066147 rs1009632431	171	K>E		No	ClinGen Ensembl
CA352223147 rs1559529277	171	K>R		No	ClinGen Ensembl
CA2329790 rs778015967	172	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1314870835 CA352223154	172	K>R		No	ClinGen TOPMed
TCGA novel	173	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2329791 rs749534475	173	A>V		No	ClinGen ExAC TOPMed gnomAD
CA352223170 rs1422034338	175	A>S		No	ClinGen gnomAD
rs1421319267 CA352223173	175	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs369895455 CA2329792	178	V>F		No	ClinGen ESP ExAC gnomAD
rs542249256 CA2329793	179	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1395140596 CA352223201	180	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA352223204 rs1331773157	180	A>V		No	ClinGen gnomAD
CA352223217 rs1327690243	182	K>T		No	ClinGen TOPMed gnomAD
rs746371770 CA2329794	184	T>I		No	ClinGen ExAC TOPMed gnomAD
CA74066199 rs981006011	186	Q>R		No	ClinGen Ensembl
rs925449918 CA74066206	189	A>V		No	ClinGen TOPMed gnomAD
CA352223265 rs1344018889	190	P>A		No	ClinGen TOPMed gnomAD
rs760276131 CA2329797	190	P>L		No	ClinGen ExAC TOPMed gnomAD
CA352223267 rs1344018889	190	P>S		No	ClinGen TOPMed gnomAD
rs1286521534 CA352223278	192	P>S		No	ClinGen gnomAD
TCGA novel	192	P>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs17081181 CA2329798	193	K>I		No	ClinGen ExAC TOPMed gnomAD
CA352223289 rs776361674	194	A>P		No	ClinGen ExAC gnomAD
CA2329799 rs776361674	194	A>S		No	ClinGen ExAC gnomAD
rs761558659 CA2329800	194	A>V		No	ClinGen ExAC gnomAD
CA74066272 rs1801012	195	Q>*		No	ClinGen TOPMed
rs8701 CA352223297	195	Q>H		No	ClinGen TOPMed
CA74066288 rs372870342	195	Q>R		No	ClinGen ESP TOPMed gnomAD
rs554565679 CA2329802	197	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2329801 rs554565679	197	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs11539048 CA74066333	198	Q>*		No	ClinGen Ensembl
rs574705007 CA2329803	200	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs1464853026 CA352223331	201	P>A		No	ClinGen TOPMed gnomAD
rs1464853026 CA352223332	201	P>S		No	ClinGen TOPMed gnomAD
CA352223342 rs1559529344	203	Q>*		No	ClinGen Ensembl
CA352223346 rs1170464057	203	Q>R		No	ClinGen gnomAD
CA352223358 rs1419814941	205	A>T		No	ClinGen gnomAD
rs1297091941 CA352223366	206	P>S		No	ClinGen gnomAD
rs1297091941 CA352223364	206	P>T		No	ClinGen gnomAD
rs1406759198 CA352223374	207	A>V		No	ClinGen TOPMed gnomAD
rs15364 CA74066389	209	K>E		No	ClinGen gnomAD
rs15370 CA74066394	209	K>R		No	ClinGen Ensembl
CA2329805 rs751482693	210	A>E		No	ClinGen ExAC TOPMed gnomAD
rs945729615 CA74066398	210	A>T		No	ClinGen TOPMed gnomAD
rs756169354 CA2329806	211	S>C		No	ClinGen ExAC gnomAD
rs756169354 CA352223395	211	S>F		No	ClinGen ExAC gnomAD
rs4854 CA74066435	211	S>P		No	ClinGen Ensembl
rs1261831013 CA352223406	213	K>R		No	ClinGen TOPMed
rs4855 CA74066496	214	K>E		No	ClinGen Ensembl
CA74066502 rs11539054	215	A>S		No	ClinGen Ensembl

No associated diseases with P50914

1 regional properties for P50914

Type	Name	Position	InterPro Accession
conserved_site	Ribosomal protein L22/L17, conserved site	126 - 150	IPR018260

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic large ribosomal subunit	The large subunit of a ribosome located in the cytosol.
cytosolic ribosome	A ribosome located in the cytosol.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.

3 GO annotations of molecular function

Name	Definition
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

4 GO annotations of biological process

Name	Definition
cytoplasmic translation	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
ribosomal large subunit biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9CR57	Rpl14	60S ribosomal protein L14	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MVFRRFVEVG	RVAYVSFGPH	AGKLVAIVDV	IDQNRALVDG	PCTQVRRQAM	PFKCMQLTDF
70	80	90	100	110	120
ILKFPHSAHQ	KYVRQAWQKA	DINTKWAATR	WAKKIEARER	KAKMTDFDRF	KVMKAKKMRN
130	140	150	160	170	180
RIIKNEVKKL	QKAALLKASP	KKAPGTKGTA	AAAAAAAAAK	VPAKKITAAS	KKAPAQKVPA
190	200	210
QKATGQKAAP	APKAQKGQKA	PAQKAPAPKA	SGKKA