AiPD: Autoinhibited Protein Database

Gene name	Tdo2
Protein name	Tryptophan 2,3-dioxygenase
Names	TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:56720
EC number	1.13.11.11: With incorporation of two atoms of oxygen
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-60 (Predicted disordered autoinhibitory region) PR

1-60 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P48776-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388635445	3	G>E	No	EVA
rs3388636725	4	C>*	No	EVA
rs3388639373	5	P>R	No	EVA
rs3388638448	5	P>S	No	EVA
rs3388638489	6	F>L	No	EVA
rs32660985	18	V>L	No	EVA
rs241866018	39	G>E	No	EVA
rs3393301835	103	R>G	No	EVA
rs3393256476	147	L>Q	No	EVA
rs3393052588	151	S>A	No	EVA
rs3393196826	153	F>*	No	EVA
rs3393261337	153	F>*	No	EVA
rs3393271715	160	L>M	No	EVA
rs3393261320	160	L>N	No	EVA
rs3393289397	176	N>H	No	EVA
rs3393065144	176	N>K	No	EVA
rs3393272088	177	R>S	No	EVA
rs3393301724	178	K>*	No	EVA
rs3393196860	178	K>N	No	EVA
rs3393052607	180	Y>D	No	EVA
rs3392873850	181	R>S	No	EVA
rs32653061	182	D>A	No	EVA
rs240582100	218	N>H	No	EVA
rs3388635424	229	N>I	No	EVA
rs226657256	245	T>N	No	EVA
rs3388632277	302	P>S	No	EVA
rs3393065110	371	Y>S	No	EVA
rs3393052574	375	R>S	No	EVA
rs3393146994	376	H>D	No	EVA
rs3393052617	376	H>L	No	EVA
rs3392873837	378	V>E	No	EVA
rs3388636712	399	Y>D	No	EVA
rs3388629813	399	Y>F	No	EVA

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P48776

		Description
EC Number	1.13.11.11	With incorporation of two atoms of oxygen
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
No GO annotations for cellular component

Name	Definition
amino acid binding	Binding to an amino acid, organic acids containing one or more amino substituents.
heme binding	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
identical protein binding	Binding to an identical protein or proteins.
metal ion binding	Binding to a metal ion.
oxygen binding	Binding to oxygen (O2).
tryptophan 2,3-dioxygenase activity	Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.

Name	Definition
protein homotetramerization	The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
response to nitroglycerin	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus.
tryptophan catabolic process to acetyl-CoA	The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA.
tryptophan catabolic process to kynurenine	The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.
tryptophan metabolic process	The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P48775	TDO2	Tryptophan 2,3-dioxygenase	Homo sapiens (Human)	PR
P21643	Tdo2	Tryptophan 2,3-dioxygenase	Rattus norvegicus (Rat)	PR
Q5EBG2	tdo2	Tryptophan 2,3-dioxygenase	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A7MBU6	tdo2a	Tryptophan 2,3-dioxygenase A	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
Q7SY53	tdo2b	Tryptophan 2,3-dioxygenase B	Danio rerio (Zebrafish) (Brachydanio rerio)	PR