P21643
Gene name |
Tdo2 |
Protein name |
Tryptophan 2,3-dioxygenase |
Names |
TDO, Tryptamin 2,3-dioxygenase, Tryptophan oxygenase, TO, TRPO, Tryptophan pyrrolase, Tryptophanase |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:64206 |
EC number |
1.13.11.11: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P21643
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P21643-F1 | Predicted | AlphaFoldDB |
No variants for P21643
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P21643 | |||||
No associated diseases with P21643
3 regional properties for P21643
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Transcription factor, T-box, conserved site | 74 - 93 | IPR018186-1 |
| conserved_site | Transcription factor, T-box, conserved site | 150 - 168 | IPR018186-2 |
| domain | T-box transcription factor, DNA-binding domain | 64 - 257 | IPR046360 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.11 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| amino acid binding | Binding to an amino acid, organic acids containing one or more amino substituents. |
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| identical protein binding | Binding to an identical protein or proteins. |
| metal ion binding | Binding to a metal ion. |
| oxygen binding | Binding to oxygen (O2). |
| tryptophan 2,3-dioxygenase activity | Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| protein homotetramerization | The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. |
| response to nitroglycerin | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus. |
| tryptophan catabolic process to acetyl-CoA | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA. |
| tryptophan catabolic process to kynurenine | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. |
| tryptophan metabolic process | The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48775 | TDO2 | Tryptophan 2,3-dioxygenase | Homo sapiens (Human) | PR |
| P48776 | Tdo2 | Tryptophan 2,3-dioxygenase | Mus musculus (Mouse) | PR |
| Q5EBG2 | tdo2 | Tryptophan 2,3-dioxygenase | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| A7MBU6 | tdo2a | Tryptophan 2,3-dioxygenase A | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q7SY53 | tdo2b | Tryptophan 2,3-dioxygenase B | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGCPFSGNS | VGYTLKNLSM | EDNEEDGAQT | GVNRASKGGL | IYGDYLQLEK | ILNAQELQSE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IKGNKIHDEH | LFIITHQAYE | LWFKQILWEL | DSVREIFQNG | HVRDERNMLK | VMTRMHRVVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IFKLLVQQFS | VLETMTALDF | NDFREYLSPA | SGFQSLQFRL | LENKIGVLQS | LRVPYNRKHY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDNFEGDYNE | LLLKSEQEQT | LLQLVEAWLE | RTPGLEPHGF | NFWGKFEKNI | LKGLEEEFLK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IQAKKDSEEK | EEQMAEFRKQ | KEVLLCLFDE | KRHDYLLSKG | ERRLSYRALQ | GALMIYFYRE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EPRFQVPFQL | LTSLMDIDTL | MTKWRYNHVC | MVHRMLGSKA | GTGGSSGYYY | LRSTVSDRYK |
| 370 | 380 | 390 | 400 | ||
| VFVDLFNLSS | YLVPRHWIPK | MNPIIHKFLY | TAEYSDSSYF | SSDESD |