AiPD: Autoinhibited Protein Database

P47756

Gene name	CAPZB
Protein name	F-actin-capping protein subunit beta
Names	CapZ beta
Species	Homo sapiens (Human)
KEGG Pathway	hsa:832
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

220-277 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

220-277 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for P47756

Entry ID	Method	Resolution	Chain	Position	Source
8F8Q	EM	279 A	H	2-270	PDB
AF-P47756-F1	Predicted				AlphaFoldDB

80 variants for P47756

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA19147684 rs868018192	3	D>Y		No	ClinGen Ensembl
CA339249094 rs1285180944	19	Q>*		No	ClinGen gnomAD
CA339249089 rs1210953883	19	Q>R		No	ClinGen TOPMed
CA339249081 rs1174855778	20	Q>K		No	ClinGen gnomAD
CA339249049 rs1467668376	22	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs185128330 CA655443	23	K>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA19147673 rs371700600	25	L>V		No	ClinGen ESP TOPMed
CA655441 rs368022261	27	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1322067694 CA339248931	30	D>N		No	ClinGen gnomAD
CA339248929 rs1322067694	30	D>Y		No	ClinGen gnomAD
rs375068236 CA19147668	31	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs993754632 CA18862509	32	V>A		No	ClinGen Ensembl
rs532876346 CA655402	34	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338785426 rs532876346	34	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338785436 rs532876346	34	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA338785417 rs1168451697	34	S>T		No	ClinGen TOPMed
rs11555671 CA18862479	43	V>A		No	ClinGen Ensembl
rs775385399 CA655399	44	D>A		No	ClinGen ExAC gnomAD
rs1181167004 CA338785191	44	D>H		No	ClinGen gnomAD
rs1178705380 CA338785027	53	K>R		No	ClinGen gnomAD
CA338785006 rs1570074362	54	V>G		No	ClinGen Ensembl
rs1457096979 CA338785003	55	V>M		No	ClinGen gnomAD
rs1164984231 CA338784994	56	G>R		No	ClinGen gnomAD
CA338784883 rs1558210195	65	N>D		No	ClinGen Ensembl
CA338782455 rs1423990074	76	S>G		No	ClinGen gnomAD
rs775970180 CA655372	77	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1570040709 CA338782268	80	D>A		No	ClinGen Ensembl
rs866090505 CA18855994	82	P>S		No	ClinGen Ensembl
CA655370 rs746198763	87	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA338782011 rs1488009114	88	M>L		No	ClinGen gnomAD
CA338781961 rs1212334949	89	P>L		No	ClinGen gnomAD
CA655369 rs779361762	89	P>S		No	ClinGen ExAC gnomAD
rs1287229316 CA338781882	91	A>P		No	ClinGen TOPMed
rs1300824082 CA338781856	92	R>W		No	ClinGen gnomAD
rs1342100350 CA338781708	95	K>R		No	ClinGen gnomAD
CA338781530 rs1570040313	98	V>G		No	ClinGen Ensembl
CA338781337 rs1468395067	103	A>T		No	ClinGen TOPMed
rs1358541641 CA338781281	104	F>C		No	ClinGen gnomAD
rs943114234 CA338781255	105	D>E		No	ClinGen TOPMed gnomAD
CA338781136 rs1259572563	109	D>E		No	ClinGen TOPMed
rs1489427449 CA338773540	112	F>Y		No	ClinGen TOPMed
CA655347 rs770183245	116	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA655344 rs754804408	132	I>M		No	ClinGen ExAC gnomAD
CA338772844 rs1310957804	141	S>L		No	ClinGen TOPMed
CA338772832 rs1237566703	142	K>E		No	ClinGen TOPMed
CA338772692 rs1312359053	145	K>R		No	ClinGen gnomAD
CA338772349 rs1209091291	153	V>L		No	ClinGen gnomAD
CA655339 rs750255932	154	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1569936021 CA338772304	155	E>K		No	ClinGen Ensembl
CA338772235 rs1558182245	157	Q>L		No	ClinGen Ensembl
CA655320 rs745616037	159	K>R		No	ClinGen ExAC gnomAD
CA655319 rs778714039	162	G>S		No	ClinGen ExAC gnomAD
CA655318 rs377121153	163	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA338771685 rs1266726751	163	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1266726751 CA338771683	163	R>L		No	ClinGen TOPMed gnomAD
CA655316 rs532731972	164	T>I		No	ClinGen 1000Genomes ExAC gnomAD
CA338771617 rs1302402418	166	H>R		No	ClinGen gnomAD
CA338771525 rs1275024781	168	K>R		No	ClinGen gnomAD
rs370957079 CA655312	172	T>M		No	ClinGen ESP ExAC gnomAD
rs1012732497 CA18845491	182	S>T		No	ClinGen TOPMed
CA655310 rs765706838	183	G>S		No	ClinGen ExAC gnomAD
CA655309 rs762321251	186	T>A		No	ClinGen ExAC
CA338771093 rs1317767416	188	N>S		No	ClinGen TOPMed gnomAD
CA338771092 rs1317767416	188	N>T		No	ClinGen TOPMed gnomAD
CA338771067 rs1404652678	190	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA655294 rs750948747	197	M>T		No	ClinGen ExAC gnomAD
rs1217360518 CA338766708	198	E>K		No	ClinGen TOPMed
CA338766669 rs1172609400	199	K>N		No	ClinGen gnomAD
rs549370964 CA655291	207	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs775574370 CA655289	213	I>F		No	ClinGen ExAC gnomAD
rs775574370 CA655288	213	I>V		No	ClinGen ExAC gnomAD
CA18839525 rs1018612131	215	R>H		No	ClinGen TOPMed gnomAD
rs1311754922 CA338765403	227	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA655264 rs762802330	229	N>D		No	ClinGen ExAC gnomAD
CA655262 rs769458863	231	I>N		No	ClinGen ExAC gnomAD
CA338765049 rs1302429895	239	I>V		No	ClinGen gnomAD
CA338765032 rs1361836900	240	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1361836900 CA338765036	240	V>L		No	ClinGen TOPMed gnomAD
CA655259 rs181908306	241	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs181908306 CA18838886	241	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD

No associated diseases with P47756

1 regional properties for P47756

Type	Name	Position	InterPro Accession
conserved_site	F-actin capping protein, beta subunit, conserved site	62 - 67	IPR019771

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

15 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
brush border	The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
cortical cytoskeleton	The portion of the cytoskeleton that lies just beneath the plasma membrane.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
F-actin capping protein complex	A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.
hippocampal mossy fiber to CA3 synapse	One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell.
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
sarcomere	The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
Schaffer collateral - CA1 synapse	A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
sperm connecting piece	The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum.
WASH complex	A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.

3 GO annotations of molecular function

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.

8 GO annotations of biological process

Name	Definition
actin polymerization or depolymerization	Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.
barbed-end actin filament capping	The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
cell morphogenesis	The developmental process in which the size or shape of a cell is generated and organized.
cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
lamellipodium assembly	Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
negative regulation of filopodium assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
regulation of cell morphogenesis	Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.
regulation of lamellipodium assembly	Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P47757	Capzb	F-actin-capping protein subunit beta	Mus musculus (Mouse)	PR
A0PFK7	CAPZB	F-actin-capping protein subunit beta	Sus scrofa (Pig)	PR

10	20	30	40	50	60
MSDQQLDCAL	DLMRRLPPQQ	IEKNLSDLID	LVPSLCEDLL	SSVDQPLKIA	RDKVVGKDYL
70	80	90	100	110	120
LCDYNRDGDS	YRSPWSNKYD	PPLEDGAMPS	ARLRKLEVEA	NNAFDQYRDL	YFEGGVSSVY
130	140	150	160	170	180
LWDLDHGFAG	VILIKKAGDG	SKKIKGCWDS	IHVVEVQEKS	SGRTAHYKLT	STVMLWLQTN
190	200	210	220	230	240
KSGSGTMNLG	GSLTRQMEKD	ETVSDCSPHI	ANIGRLVEDM	ENKIRSTLNE	IYFGKTKDIV
250	260	270
NGLRSVQTFA	DKSKQEALKN	DLVEALKRKQ	QC