P47061
Gene name |
VPS53 (YJL029C, J1258) |
Protein name |
Vacuolar protein sorting-associated protein 53 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YJL029C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P47061
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3NS4 | X-ray | 290 A | A | 554-822 | PDB |
| AF-P47061-F1 | Predicted | AlphaFoldDB |
15 variants for P47061
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s10-390828 | 7 | D>E | No | SGRP | |
| s10-390772 | 26 | N>S | No | SGRP | |
| s10-390707 | 48 | E>K | No | SGRP | |
| s10-389408 | 481 | A>T | No | SGRP | |
| s10-389187 | 554 | Q>H | No | SGRP | |
| s10-389069 | 594 | T>A | No | SGRP | |
| s10-389068 | 594 | T>I | No | SGRP | |
| s10-389029 | 607 | A>V | No | SGRP | |
| s10-388820 | 677 | M>V | No | SGRP | |
| s10-388633 | 739 | P>L | No | SGRP | |
| s10-388634 | 739 | P>S | No | SGRP | |
| s10-388624 | 742 | N>S | No | SGRP | |
| s10-388477 | 791 | T>N | No | SGRP | |
| s10-388467 | 794 | I>M | No | SGRP | |
| s10-388387 | 821 | G>D | No | SGRP |
No associated diseases with P47061
No regional properties for P47061
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P47061 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| GARP complex | A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular sphingolipid homeostasis | Any biological process involved in the maintenance of an internal steady state of sphingolipids at the level of the cell. |
| Golgi to vacuole transport | The directed movement of substances from the Golgi to the vacuole. |
| protein targeting to vacuole | The process of directing proteins towards the vacuole, usually using signals contained within the protein. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| F4I7Y2 | At1g50970 | Vacuolar protein sorting-associated protein 53 B | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLEGTVDYDP | LEDITNILFS | KESLNNIDEL | ISITRSYKKQ | LQEDILKEEN | ELKEHPKNSA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EIEASLRKVF | QDFKETQDVS | ASTELTISNL | TEGISYLDIA | KKNLTHSLTL | FQNLKILTDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YIQCNELLSQ | GSFKKMVSPY | KIMCSLAENT | FISYKSLDEI | NYLLSSISRL | KGDTLSKIKQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NYNALFSGGN | ISEHDTALTM | ELREGACELL | DCDTSTRAQM | IDWCLDKLLF | EMKEIFRVDD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EAGSLENLSR | RYIYFKKILN | NFNSKFADYF | LKDWEMAVRL | TTTFYHITHK | DLQTLLKREF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KDKNPSIDLF | MTALQSTLDF | EKYIDVRFSK | KIKEPKLSSC | FEPYLTLWVS | HQNQMMEKKF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSYMSEPKYP | SNETESLVLP | SSADLFRTYR | SVLTQTLELI | DNNANDSILT | SLANFFSRWL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QTYSQKILLP | LLLPDNIEVQ | DKLEAAKYTV | LLINTADYCA | TTIDQLEDKL | SEFSGNREKL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ANSFTKTKNI | YDDLLAKGTS | FLLNRVIPLD | LNFVWREFIN | NDWSNAAIED | YSRYMVTLKS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VLKMPALTDA | SIKQQQEQPS | TLAFILSQFN | RDVYKWNFLD | KVIDIITTNF | VSNTIRLLQP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VPPFSLAGSK | RKFETRTVVN | IGEQLLLDLE | LLKEIFHTLP | ESVSNDSDLR | ENTSYKRVKR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| HADNNIDQLL | KFIKLLMAPL | DSADDYYETY | SKLTNNNPDS | AVWSFVLALK | GIPWDLALWK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KLWSAYNLET | DDTDEGSRPD | SNRDLFIFKW | DKVLLGQFEN | NLARMQDPNW | SKFVRQDLKI |
| 790 | 800 | 810 | 820 | ||
| SPPVMKRIVS | TPQIQQQKEE | QKKQSLSVKD | FVSHSRFFNR | GT |