F4I7Y2
PR
Gene name |
At1g50970 (F8A12.19) |
Protein name |
Vacuolar protein sorting-associated protein 53 B |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G50970 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for F4I7Y2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-F4I7Y2-F1 | Predicted | AlphaFoldDB |
109 variants for F4I7Y2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_18896326_G_A | 2 | D>N | No | 1000Genomes | |
| ENSVATH01339330 | 3 | K>N | No | 1000Genomes | |
| ENSVATH13493708 | 4 | S>P | No | 1000Genomes | |
| tmp_1_18896355_C_A | 11 | N>K | No | 1000Genomes | |
| ENSVATH00092072 | 13 | M>T | Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c and 8 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_1_18896364_C_A | 14 | F>L | No | 1000Genomes | |
| ENSVATH13493725 | 18 | A>V | No | 1000Genomes | |
| tmp_1_18896483_C_A | 19 | S>Y | No | 1000Genomes | |
| tmp_1_18896493_T_A | 22 | C>* | No | 1000Genomes | |
| tmp_1_18896501_CT_TT,C | 25 | S>F | No | 1000Genomes | |
| ENSVATH13493728 | 25 | S>P | No | 1000Genomes | |
| ENSVATH00092073 | 30 | I>S | No | 1000Genomes | |
| ENSVATH04928615 | 31 | C>R | No | 1000Genomes | |
| tmp_1_18896519_G_A | 31 | C>Y | No | 1000Genomes | |
| ENSVATH13493732 | 33 | E>K | No | 1000Genomes | |
| ENSVATH13493734 | 34 | I>L | No | 1000Genomes | |
| ENSVATH13493735 | 37 | V>D | No | 1000Genomes | |
| ENSVATH13493736 | 44 | V>A | No | 1000Genomes | |
| tmp_1_18896560_G_A | 45 | V>I | No | 1000Genomes | |
| ENSVATH13493737 | 55 | A>V | No | 1000Genomes | |
| ENSVATH04928617 | 60 | N>T | No | 1000Genomes | |
| ENSVATH14282269 | 65 | A>V | No | 1000Genomes | |
| ENSVATH04928622 | 77 | K>* | No | 1000Genomes | |
| ENSVATH13493742 | 82 | Q>L | No | 1000Genomes | |
| ENSVATH13493743 | 83 | T>A | No | 1000Genomes | |
| ENSVATH14282270 | 84 | E>A | No | 1000Genomes | |
| ENSVATH13493755 | 94 | I>V | No | 1000Genomes | |
| ENSVATH01339333 | 96 | K>E | No | 1000Genomes | |
| tmp_1_18896833_G_A | 108 | V>I | No | 1000Genomes | |
| tmp_1_18896849_G_A | 113 | R>H | No | 1000Genomes | |
| tmp_1_18897086_T_A | 118 | V>E | No | 1000Genomes | |
| tmp_1_18897092_C_G | 120 | A>G | No | 1000Genomes | |
| tmp_1_18897112_A_T | 127 | M>L | No | 1000Genomes | |
| ENSVATH04928632 | 134 | K>E | No | 1000Genomes | |
| ENSVATH00092076 | 143 | I>M | No | 1000Genomes | |
| tmp_1_18897384_A_G | 151 | K>E | No | 1000Genomes | |
| tmp_1_18897388_C_A | 152 | A>E | No | 1000Genomes | |
| tmp_1_18897387_G_T | 152 | A>S | No | 1000Genomes | |
| ENSVATH13493775 | 162 | L>F | No | 1000Genomes | |
| tmp_1_18897471_G_C | 180 | D>H | No | 1000Genomes | |
| tmp_1_18897784_G_C | 189 | E>D | No | 1000Genomes | |
| ENSVATH04928651 | 190 | T>I | No | 1000Genomes | |
| tmp_1_18897802_G_T | 195 | L>F | No | 1000Genomes | |
| tmp_1_18897804_T_A | 196 | L>Q | No | 1000Genomes | |
| tmp_1_18897814_A_T | 199 | L>F | No | 1000Genomes | |
| ENSVATH04928652 | 203 | C>Y | No | 1000Genomes | |
| ENSVATH04928653 | 217 | L>W | No | 1000Genomes | |
| ENSVATH13493782 | 224 | R>W | No | 1000Genomes | |
| tmp_1_18897917_G_A | 234 | V>I | No | 1000Genomes | |
| ENSVATH13493791 | 244 | I>V | No | 1000Genomes | |
| tmp_1_18898074_G_A | 260 | G>R | No | 1000Genomes | |
| tmp_1_18898087_T_C | 264 | I>T | No | 1000Genomes | |
| ENSVATH13493792 | 265 | F>I | No | 1000Genomes | |
| ENSVATH13493793 | 266 | P>R | No | 1000Genomes | |
| ENSVATH13493794 | 269 | W>* | No | 1000Genomes | |
| tmp_1_18898108_T_C | 271 | V>A | No | 1000Genomes | |
| tmp_1_18898144_C_A | 283 | T>K | No | 1000Genomes | |
| ENSVATH04928671 | 301 | E>G | No | 1000Genomes | |
| tmp_1_18898682_G_A | 309 | R>K | No | 1000Genomes | |
| ENSVATH04928680 | 311 | L>V | No | 1000Genomes | |
| tmp_1_18898738_G_T,A | 328 | G>* | No | 1000Genomes | |
| tmp_1_18898738_G_T,A | 328 | G>R | No | 1000Genomes | |
| tmp_1_18898760_G_C | 335 | G>A | No | 1000Genomes | |
| tmp_1_18898766_A_G | 337 | N>S | No | 1000Genomes | |
| tmp_1_18898895_G_C | 346 | G>A | No | 1000Genomes | |
| ENSVATH00092079 | 352 | F>Y | No | 1000Genomes | |
| tmp_1_18898956_A_C | 366 | E>D | No | 1000Genomes | |
| ENSVATH14282294 | 371 | L>P | No | 1000Genomes | |
| tmp_1_18899064_G_A | 381 | D>N | No | 1000Genomes | |
| ENSVATH01339344 | 383 | E>D | No | 1000Genomes | |
| ENSVATH01339345 | 385 | E>* | No | 1000Genomes | |
| ENSVATH00092080 | 385 | E>D | No | 1000Genomes | |
| tmp_1_18899106_T_A | 395 | Y>N | No | 1000Genomes | |
| ENSVATH00092082 | 399 | L>V | Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c with 8 hrs daylight and vernalized (5 wks and 4c)] Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Number of days required for the bolt height to reach 5cm [23c and 16hrs daylight. vernalized for 8 wks at 5c and 8hrs daylight] Flowering time was scored as the number of days for the bolt to reach 5cm [20-22c with natural light from the middle of october 2002 till march 2003. vernalized for 8wks at 4c and 8hrs daylight] Number of days required for the bolt height to reach 5cm [23c and 16hrs daylight. vernalized for 2 wks at 5c and 8hrs daylight] Leaf number was scored as the number of rosette leaves and the number of cauline leaves when the bolt reached 5cm [20-22c and natural light from the middle of october 2002 till march 2003. vernalized for 8wks at 4c and 8hrs daylight] Number of days required for the bolt height to reach 5cm [23c and 16hrs daylight. vernalized for 4 wks at 5c and 8hrs daylight] Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c with 16 hrs daylight and vernalized (5 wks at 4c)] Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c and 8 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] Flowering time was scored as the number of days between germination date and appearance of the first flower [growth in field with natural light and started in october] Flowering time was scored as the number of days for the bolt to reach 5cm [20-22c and natural light from the middle of october 2002 till march 2003] Plants were checked bi-weekly for presence of first buds and the average leaf number at flowering time of 4 plants of the same accession were collected [22c and 16 hrs daylight] [EnsemblGenome] | No | 1000Genomes |
| tmp_1_18899445_G_A | 406 | M>I | No | 1000Genomes | |
| ENSVATH04928709 | 410 | K>N | No | 1000Genomes | |
| ENSVATH04928710 | 416 | R>G | No | 1000Genomes | |
| ENSVATH14282308 | 416 | R>I | No | 1000Genomes | |
| ENSVATH04928712 | 419 | E>D | No | 1000Genomes | |
| ENSVATH01339346 | 432 | Y>S | No | 1000Genomes | |
| ENSVATH00092085 | 435 | L>F | No | 1000Genomes | |
| tmp_1_18899699_G_T | 436 | V>L | No | 1000Genomes | |
| ENSVATH13493833 | 442 | R>I | No | 1000Genomes | |
| tmp_1_18899726_G_A | 445 | A>T | No | 1000Genomes | |
| ENSVATH04928718 | 448 | K>* | No | 1000Genomes | |
| ENSVATH04928722 | 451 | A>T | No | 1000Genomes | |
| ENSVATH04928723 | 452 | S>F | No | 1000Genomes | |
| tmp_1_18899836_AT_GT,A | 458 | I>V | No | 1000Genomes | |
| ENSVATH00092086 | 460 | T>A | No | 1000Genomes | |
| tmp_1_18899848_C_T | 462 | R>C | No | 1000Genomes | |
| tmp_1_18899857_T_A | 465 | F>I | No | 1000Genomes | |
| ENSVATH13493860 | 470 | P>L | No | 1000Genomes | |
| tmp_1_18899883_T_G | 473 | F>L | No | 1000Genomes | |
| ENSVATH04928726 | 478 | V>E | No | 1000Genomes | |
| tmp_1_18900032_G_A | 492 | D>N | No | 1000Genomes | |
| ENSVATH13493864 | 494 | F>I | No | 1000Genomes | |
| ENSVATH00092087 | 500 | R>T | No | 1000Genomes | |
| ENSVATH01339348 | 501 | I>M | No | 1000Genomes | |
| ENSVATH04928728 | 510 | T>K | No | 1000Genomes | |
| tmp_1_18900122_A_T | 522 | N>Y | No | 1000Genomes | |
| ENSVATH00092088 | 525 | P>S | No | 1000Genomes | |
| ENSVATH01339349 | 528 | R>Q | No | 1000Genomes | |
| tmp_1_18900147_A_C | 530 | K>T | No | 1000Genomes | |
| ENSVATH04928729 | 537 | L>* | No | 1000Genomes | |
| ENSVATH00092089 | 537 | L>F | No | 1000Genomes | |
| tmp_1_18900177_C_T | 540 | A>V | No | 1000Genomes | |
| tmp_1_18900188_G_A | 544 | A>T | No | 1000Genomes | |
| tmp_1_18900213_A_C | 552 | Y>S | No | 1000Genomes | |
| ENSVATH01339350 | 556 | G>E | No | 1000Genomes |
No associated diseases with F4I7Y2
1 regional properties for F4I7Y2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Vps53, N-terminal | 3 - 378 | IPR007234 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| GARP complex | A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P47061 | VPS53 | Vacuolar protein sorting-associated protein 53 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDKSSGLDFI | NQMFPVEASL | SCVESFMQKI | CDEIRRVDAT | ILAVVSQQGN | SGTRAKENLN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DAICAAEELS | HKIQEIKSKA | EQTEAMVQDI | CSDIKKLDFA | KKNITTAVTA | LSRLTMLVSA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VQQLQVMTSK | RQYKEAATQL | EAINELCNHF | KAYMDLPKIM | ELREKLKNIK | QILKFHVFSD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FSSLGTGTET | EELFLLKKLS | DSCLVVDALE | PSVREELINN | FCSRELTSYE | QIYVGAELKT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LDEIELIYNQ | LSCLIRKNQG | KWTIFPASWH | VPYRLCIQLS | RKTRVQVESI | LVNLKEKSDV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKLLLELKRT | LEFERELEMK | FGGGGSIGDD | IIGGGGNNSQ | KFNFRGMISS | CFEPHLTIYI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EKEEMELMQL | LEKVVQEETW | DIEEELGCHS | ENSVYLMLLD | AHDMKMILLK | VPSLARQPEA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SALLVKTATA | SYVKLVNHQM | KRAEAVLKVI | ASPIVTVIDT | YRALFPEETP | MEFQRILVLK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GLTKAEQQSI | LDDFNNHSSR | ITQLSVAAKT | PEAHALPLAL | TNVAPAVRFK | ANSEEVLTRA |
| 550 | 560 | ||||
| ASAATTSFMK | LYALTGAAKD | RPFRKLFNP |