P46580

PR
Gene name
prmt-5
Protein name
Protein arginine N-methyltransferase 5
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C34E10.5
EC number
2.1.1.320: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P46580

Entry ID Method Resolution Chain Position Source
3UA3 X-ray 300 A A/B 1-734 PDB
3UA4 X-ray 300 A A/B 1-734 PDB
AF-P46580-F1 Predicted AlphaFoldDB

No variants for P46580

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P46580

No associated diseases with P46580

3 regional properties for P46580

Type Name Position InterPro Accession
domain PRMT5 arginine-N-methyltransferase 354 - 528 IPR035075
domain PRMT5, TIM barrel domain 78 - 330 IPR035247
domain PRMT5, oligomerisation domain 531 - 732 IPR035248

Functions

Description
EC Number 2.1.1.320 Methyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription repressor complex A protein complex that possesses activity that prevents or downregulates transcription.

8 GO annotations of molecular function

Name Definition
[myelin basic protein]-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine.
DNA-binding transcription factor binding Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
histone methyltransferase activity (H4-R3 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4.
histone-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.
p53 binding Binding to one of the p53 family of proteins.
protein-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine.
protein-arginine omega-N monomethyltransferase activity Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine
protein-arginine omega-N symmetric methyltransferase activity +Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues.

11 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone arginine methylation The modification of a histone by addition of a methyl group to an arginine residue.
histone H4-R3 methylation The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone.
intrinsic apoptotic signaling pathway in response to DNA damage The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
locomotory behavior The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
negative regulation of DNA damage response, signal transduction by p53 class mediator Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
peptidyl-arginine methylation, to symmetrical-dimethyl arginine The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine.
peptidyl-arginine N-methylation The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
response to odorant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38274 HSL7 Protein arginine N-methyltransferase HSL7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MSNRTYADNL FPQQVAEQHE EQMSSGSSPK SNSPSRSISS VEAANSRIHI GWMATTLDVA
70 80 90 100 110 120
ENLDRHVATF CTRLGEFKYN FVVYPIGGVV RAFWTPNGSA ENHPPVIDLP DVQLRNDLWE
130 140 150 160 170 180
SYVVGKISPW IDCDSSDPAF ASLSEEHLLK ELSYICYLGL QTMAIELTRI SSPRTAAILK
190 200 210 220 230 240
KWIWTRNSRF TVWVQLPSAI EKCKDYDAFT IEHVDLWTIW ADFRKNCGNF SGVYFQVALT
250 260 270 280 290 300
ISSELPDELT ELKLVDRWKA EPLAAFVIES GLFISGRNGE ASIPSAHINL LKHLWTTDAL
310 320 330 340 350 360
RIVLRATTDT FKYNTSIKSE YSQALRHAVR NVNYRSRPDV GEGSNDSTHY LNVIEYKDVL
370 380 390 400 410 420
QAPLQPLSEN LDSGVYNTFE QDQIKYDVYG EAVVGALKDL GADGRKTVVI YLLGGGRGPI
430 440 450 460 470 480
GTKILKSERE YNNTFRQGQE SLKVKLYIVE KNPNAIVTLK YMNVRTWKRR VTIIESDMRS
490 500 510 520 530 540
LPGIAKDRGF EQPDIIVSEL LGSFGDNELS PECLDGVTGF LKPTTISIPQ KYTSYVKPIM
550 560 570 580 590 600
STHIHQTIKA QSIPYLSRAI PSHGRGEPEL DEDEMWIQKY PQGHVRNNMD QIYVVYLSKY
610 620 630 640 650 660
IPLAETTKPV FTFEHPNFMN SSNERSDSIE FVMDRNADLM GFAGYFDLQL YKTVMLSIEP
670 680 690 700 710 720
STHTPGMVSW FPAVIPLRDQ LRVGEGDRIS LKIDRKVDNT GVWYEWHVEK KKTNGESVST
730
PIQNPNGESY YMRM