P45522
Gene name |
kefB |
Protein name |
Glutathione-regulated potassium-efflux system protein KefB |
Names |
K(+)/H(+) antiporter, NEM-activable K(+)/H(+) antiporter |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b3350 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P45522
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P45522-F1 | Predicted | AlphaFoldDB |
No variants for P45522
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P45522 | |||||
No associated diseases with P45522
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| potassium:proton antiporter complex | A protein complex which is capable of potassium:proton antiporter activity. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutathione-regulated potassium exporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state. |
| solute:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P03819 | kefC | Glutathione-regulated potassium-efflux system protein KefC | Escherichia coli (strain K12) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGSDFLLAG | VLFLFAAVAA | VPLASRLGIG | AVLGYLLAGI | AIGPWGLGFI | SDVDEILHFS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELGVVFLMFI | IGLELNPSKL | WQLRRSIFGV | GAAQVLLSAA | LLAGLLMLTD | FAWQAAVVGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IGLAMSSTAM | ALQLMREKGM | NRSESGQLGF | SVLLFQDLAV | IPALALVPLL | AGSADEHFDW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MKVGMKVLAF | VGMLIGGRYL | LRPVFRFIAA | SGVREVFTAA | TLLLVLGSAL | FMDALGLSMA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LGTFIAGVLL | AESEYRHELE | TAIDPFKGLL | LGLFFISVGM | SLNLGVLYTH | LLWVVISVVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVAVKILVLY | LLARLYGVRS | SERMQFAGVL | SQGGEFAFVL | FSTASSQRLF | QGDQMALLLV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVTLSMMTTP | LLMKLVDKWL | SRQFNGPEEE | DEKPWVNDDK | PQVIVVGFGR | FGQVIGRLLM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ANKMRITVLE | RDISAVNLMR | KYGYKVYYGD | ATQVDLLRSA | GAEAAESIVI | TCNEPEDTMK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LVEICQQHFP | HLHILARARG | RVEAHELLQA | GVTQFSRETF | SSALELGRKT | LVTLGMHPHQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| AQRAQLHFRR | LDMRMLRELI | PMHADTVQIS | RAREARRELE | EIFQREMQQE | RRQLDGWDEF |
| E |