P03819
Gene name |
kefC |
Protein name |
Glutathione-regulated potassium-efflux system protein KefC |
Names |
K(+)/H(+) antiporter |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b0047 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P03819
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3EYW | X-ray | 240 A | A/B | 401-620 | PDB |
| 3L9W | X-ray | 175 A | A/B | 401-620 | PDB |
| 3L9X | X-ray | 210 A | A/B | 401-620 | PDB |
| AF-P03819-F1 | Predicted | AlphaFoldDB |
No variants for P03819
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P03819 | |||||
No associated diseases with P03819
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| potassium:proton antiporter complex | A protein complex which is capable of potassium:proton antiporter activity. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| glutathione-regulated potassium exporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state. |
| nucleotide binding | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| solute:proton antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). |
| toxic substance binding | Binding to a toxic substance, a poisonous substance that causes damage to biological systems. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| intracellular pH elevation | Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| potassium ion transport | The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| regulation of intracellular pH | Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. |
| regulation of pH | Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. |
| response to methylglyoxal | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal. |
| response to toxic substance | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P45522 | kefB | Glutathione-regulated potassium-efflux system protein KefB | Escherichia coli (strain K12) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDSHTLIQAL | IYLGSAALIV | PIAVRLGLGS | VLGYLIAGCI | IGPWGLRLVT | DAESILHFAE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IGVVLMLFII | GLELDPQRLW | KLRAAVFGCG | ALQMVICGGL | LGLFCMLLGL | RWQVAELIGM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TLALSSTAIA | MQAMNERNLM | VTQMGRSAFA | VLLFQDIAAI | PLVAMIPLLA | TSSASTTMGA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FALSALKVAG | ALVLVVLLGR | YVTRPALRFV | ARSGLREVFS | AVALFLVFGF | GLLLEEVGLS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MAMGAFLAGV | LLASSEYRHA | LESDIEPFKG | LLLGLFFIGV | GMSIDFGTLL | ENPLRIVILL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGFLIIKIAM | LWLIARPLQV | PNKQRRWFAV | LLGQGSEFAF | VVFGAAQMAN | VLEPEWAKSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLAVALSMAA | TPILLVILNR | LEQSSTEEAR | EADEIDEEQP | RVIIAGFGRF | GQITGRLLLS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SGVKMVVLDH | DPDHIETLRK | FGMKVFYGDA | TRMDLLESAG | AAKAEVLINA | IDDPQTNLQL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TEMVKEHFPH | LQIIARARDV | DHYIRLRQAG | VEKPERETFE | GALKTGRLAL | ESLGLGPYEA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RERADVFRRF | NIQMVEEMAM | VENDTKARAA | VYKRTSAMLS | EIITEDREHL | SLIQRHGWQG |
| 610 | |||||
| TEEGKHTGNM | ADEPETKPSS |