AiPD: Autoinhibited Protein Database

Gene name	SAP155 (YFR040W)
Protein name	SIT4-associating protein SAP155
Names
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YFR040W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

25-148 (Predicted disordered autoinhibitory region) PR

25-148 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P43612-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s06-234367	47	V>I	No	SGRP
s06-234437	70	K>T	No	SGRP
s06-234572	115	K>R	No	SGRP
s06-234643	139	N>Y	No	SGRP
s06-234820	198	K>E	No	SGRP
s06-234835	203	V>M	No	SGRP
s06-234901	225	V>I	No	SGRP
s06-234938	237	K>R	No	SGRP
s06-234956	243	S>N	No	SGRP
s06-234998	257	G>V	No	SGRP
s06-235118	297	S>N	No	SGRP
s06-235306	360	L>I	No	SGRP
s06-235433	402	S>N	No	SGRP
s06-236145	639	N>K	No	SGRP
s06-236209	661	K>Q	No	SGRP
s06-236243	672	V>A	No	SGRP
s06-236242	672	V>I	No	SGRP
s06-236449	741	T>S	No	SGRP
s06-236833	869	N>D	No	SGRP
s06-236878	884	E>K	No	SGRP
s06-236941	905	V>I	No	SGRP
s06-237128	967	S>N	No	SGRP

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P43612

		Description
EC Number
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein serine/threonine phosphatase complex	A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.

Name	Definition
protein phosphatase binding	Binding to a protein phosphatase.
protein phosphatase regulator activity	Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.

Name	Definition
G1/S transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
regulation of phosphoprotein phosphatase activity	Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53036	SAP4	SIT4-associating protein SAP4	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
O75170	PPP6R2	Serine/threonine-protein phosphatase 6 regulatory subunit 2	Homo sapiens (Human)	PR