P41438
PR
Gene name |
Slc19a1 |
Protein name |
Reduced folate transporter |
Names |
Intestinal folate carrier 1, IFC-1, Plasma membrane folate antiporter SLC19A1, Reduced folate carrier 1, RFC-1, RFC1, Solute carrier family 19 member 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:20509 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P41438
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P41438-F1 | Predicted | AlphaFoldDB |
35 variants for P41438
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389105176 | 7 | V>M | No | EVA | |
| rs3389109322 | 21 | E>* | No | EVA | |
| rs3389097050 | 43 | P>L | No | EVA | |
| rs3389110172 | 56 | K>N | No | EVA | |
| rs3400707895 | 147 | Y>D | No | EVA | |
| rs3401495201 | 153 | Y>* | No | EVA | |
| rs3401108714 | 153 | Y>N | No | EVA | |
| rs3389113928 | 176 | G>* | No | EVA | |
| rs3389119537 | 179 | S>I | No | EVA | |
| rs3413076987 | 180 | T>I | No | EVA | |
| rs3389097123 | 204 | P>H | No | EVA | |
| rs259155889 | 216 | A>V | No | EVA | |
| rs47989714 | 228 | H>N | No | EVA | |
| rs262724347 | 233 | R>Q | No | EVA | |
| rs3389106851 | 235 | E>K | No | EVA | |
| rs3389081882 | 240 | D>V | No | EVA | |
| rs3389119559 | 242 | M>T | No | EVA | |
| rs3389101188 | 259 | V>M | No | EVA | |
| rs3389097097 | 272 | L>F | No | EVA | |
| rs3389110159 | 277 | N>Y | No | EVA | |
| rs49109042 | 337 | G>S | No | EVA | |
| rs3389097077 | 338 | V>L | No | EVA | |
| rs3389106809 | 348 | C>F | No | EVA | |
| rs3389101267 | 364 | L>I | No | EVA | |
| rs3389106836 | 366 | R>P | No | EVA | |
| rs3389119581 | 371 | F>L | No | EVA | |
| rs3413041608 | 371 | F>Y | No | EVA | |
| rs3389119624 | 376 | A>T | No | EVA | |
| rs3389109339 | 420 | Q>H | No | EVA | |
| rs3389075415 | 431 | Y>N | No | EVA | |
| rs3400960908 | 451 | C>* | No | EVA | |
| rs3389101219 | 456 | H>N | No | EVA | |
| rs3389111212 | 486 | P>S | No | EVA | |
| rs3389113952 | 505 | D>H | No | EVA | |
| rs3389097112 | 508 | V>I | No | EVA |
No associated diseases with P41438
No regional properties for P41438
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P41438 | |||
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| brush border membrane | The portion of the plasma membrane surrounding the brush border. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| 2',3'-cyclic GMP-AMP binding | Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages. |
| antiporter activity | Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
| folate:anion antiporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF. |
| folic acid binding | Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. |
| folic acid transmembrane transporter activity | Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. |
| methotrexate transmembrane transporter activity | Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. |
| organic anion transmembrane transporter activity | Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. |
| xenobiotic transmembrane transporter activity | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| female pregnancy | The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. |
| folate import across plasma membrane | The directed movement of folic acid from outside of a cell, across the plasma membrane and into the cytosol. |
| folate transmembrane transport | The process in which a folic acid, or one of its derivatives (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) is transported across a membrane. |
| folic acid transport | The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. |
| methotrexate transport | The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. |
| organic anion transport | The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
| xenobiotic transmembrane transport | The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BZV2 | SLC19A3 | Thiamine transporter 2 | Homo sapiens (Human) | PR |
| P41440 | SLC19A1 | Reduced folate transporter | Homo sapiens (Human) | PR |
| O45166 | folt-2 | Folate-like transporter 2 | Caenorhabditis elegans | PR |
| Q17766 | folt-1 | Folate transporter 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVPTGQVAEK | QAYEEPRQDH | ELKSWRCLVF | YLCFFGFMAQ | LRPGESFITP | FLLERKFTKE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QVTNEIIPML | PYSHLAVLVP | VFLLTDYLRY | KPVLVLQCLS | FVCVWLLLLL | GTSVVHMQLM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EVFYSVTMAA | RIAYSSYIFS | LVHPSRYQRM | ASYSRAAVLL | GVFISSVLGQ | ALVTVGHIST |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YTLNCVSLGF | ILFSLVLSLF | LKRPKRSLFF | NRSTLARGAL | PCELDQMHPG | PDRPETRKLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RMLGTCRDSF | LVRMLSELVE | NARQPQLRLW | CLWWVFNSSG | YYLITYYVHV | LWRSTDSSLS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YNGAVDAAST | LLSAITSFSA | GFLSIRWTLW | SKLVIAGVIA | IQASLVFCMF | QIRDIWVCYV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TFVLFRGAYQ | FLVPIATFQI | ASSLSKELCA | LVFGINTFLA | TALKTCITLV | VSDKRGLGLQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VRDQFRIYFI | YFLMLSITCF | AWAGLDGLRY | CQRGRHQPLA | QAQELRSPLE | TSVQAISLQD |
| 490 | 500 | 510 | |||
| GDLRGPQPSA | PQLLSEDGME | DDRGDLRVEA | KA |