O45166
Gene name |
folt-2 (F37B4.7) |
Protein name |
Folate-like transporter 2 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F37B4.7 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O45166
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O45166-F1 | Predicted | AlphaFoldDB |
No variants for O45166
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O45166 | |||||
No associated diseases with O45166
No regional properties for O45166
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O45166 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| folic acid binding | Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. |
| vitamin transmembrane transporter activity | Enables the transfer of a vitamin from one side of a membrane to the other. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BZV2 | SLC19A3 | Thiamine transporter 2 | Homo sapiens (Human) | PR |
| P41440 | SLC19A1 | Reduced folate transporter | Homo sapiens (Human) | PR |
| P41438 | Slc19a1 | Reduced folate transporter | Mus musculus (Mouse) | PR |
| Q17766 | folt-1 | Folate transporter 1 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEQWKVMVLI | CMYGAVKEFR | PTEPYMYEYQ | HTVLNMSEQT | LNSQVYPIWT | YSYLITLIPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FLLTDVFLYK | PLLVFEAFSY | FLCWVIFVFG | KSVWSQQVLE | VFYGWATATE | IAYFAYIYVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPKTEYKSAT | AFTRAALLVG | RFLAYALAQL | LIGLNWTSYS | TLNIISLVAM | TIAVFLALIL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PGVEWKEAYE | KKLEDNNVQG | NLKEIVDQSS | YMDYLRMFFV | GLRHNLMAIY | RNPLILKWSV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| WSALSSCIFY | QVTNYTQTLW | GTLPESANRY | NGITEALVPL | LGIPADLITR | QLNVNWNRWG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DLLLAVGSIG | QAGLLFWMSQ | SHHIVVLYLS | YIFYRVIYQL | TTTIAQSTLA | FSLDSRLFGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LFGINTFVAL | LLQSILTAVV | IDWQKLDIRP | QFVVYSCYHL | VVAFGFAIIF | GIWASRRFFK |
| TSTN |