AiPD: Autoinhibited Protein Database

P41208

Gene name	CETN2 (CALT, CEN2)
Protein name	Centrin-2
Names	Caltractin isoform 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:1069
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-55 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-55 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

13 structures for P41208

Entry ID	Method	Resolution	Chain	Position	Source
1M39	NMR	-	A	84-172	PDB
1ZMZ	NMR	-	A	1-98	PDB
2A4J	NMR	-	A	94-172	PDB
2GGM	X-ray	235 A	A/B	1-172	PDB
2K2I	NMR	-	A	94-172	PDB
2OBH	X-ray	180 A	A/B	26-168	PDB
8EBS	EM	400 A	J	1-172	PDB
8EBT	EM	390 A	J	103-172	PDB
8EBV	EM	710 A	J	1-172	PDB
8EBW	EM	560 A	J	1-172	PDB
8EBX	EM	360 A	J	1-172	PDB
8J07	EM	410 A	f2	1-172	PDB
AF-P41208-F1	Predicted				AlphaFoldDB

56 variants for P41208

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1378178181 CA415286424	5	F>I		No	ClinGen TOPMed
CA415286419 rs1556843100	5	F>L		No	ClinGen gnomAD
rs782022540 CA10544652	10	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1166006334 CA415286374	11	A>V		No	ClinGen TOPMed
rs782610968 CA10544649	18	R>G		No	ClinGen ExAC gnomAD
CA415286330 rs1556843090	18	R>T		No	ClinGen gnomAD
CA10544648 rs201278395	19	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs782259976 CA10544647	25	L>F		No	ClinGen ExAC gnomAD
rs782631653 COSM310060 CA10544646	28	E>Q	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA337607208 rs927416490	31	Q>E		No	ClinGen TOPMed
rs1385784934 CA415286217	34	R>Q		No	ClinGen TOPMed
rs782542011 CA10544645	34	R>W		No	ClinGen ExAC gnomAD
rs781887223 CA10544644	35	E>*		No	ClinGen ExAC gnomAD
rs782559928 CA10544643	35	E>V		No	ClinGen ExAC gnomAD
CA10544642 rs782498685 COSM1682980	41	D>N	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA10544641 rs781822475	42	A>V		No	ClinGen ExAC TOPMed gnomAD
CA415286157 rs1236078369	43	D>V		No	ClinGen TOPMed
rs782122615 CA10544639	44	G>E		No	ClinGen ExAC TOPMed gnomAD
CA10544638 rs150888300	48	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA10544637 rs782803993	49	D>E		No	ClinGen ExAC TOPMed gnomAD
rs782530915 CA415286116	50	V>F		No	ClinGen ExAC TOPMed gnomAD
rs782530915 CA10544636	50	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	56	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10544618 rs781816418	57	M>V		No	ClinGen ExAC gnomAD
rs1267579826 CA415286028	61	G>A		No	ClinGen TOPMed
rs1569470208 CA415286008	64	P>S		No	ClinGen Ensembl
CA415285965 rs1210530347	70	K>Q		No	ClinGen TOPMed
CA10544617 rs782787803	70	K>R		No	ClinGen ExAC gnomAD
CA415285957 rs1235618391	71	K>E		No	ClinGen TOPMed
rs1482821975 CA415285939	73	I>L		No	ClinGen TOPMed
rs782033927 CA10544615	80	G>V		No	ClinGen ExAC gnomAD
CA337607113 rs927332703	82	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs374235428 CA337607110	87	G>A		No	ClinGen ESP gnomAD
rs374235428 CA415285835	87	G>D		No	ClinGen ESP gnomAD
CA415285833 rs868987630	88	D>Y		No	ClinGen Ensembl
rs1556842956 CA415285744	98	S>P		No	ClinGen gnomAD
TCGA novel	102	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	105	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10544595 rs782086390	111	K>N		No	ClinGen ExAC gnomAD
rs782779595 CA10544593	122	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA415285508 rs1288642859	131	K>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA415285496 rs1556842933 COSM3800473	132	E>D	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1321829537 CA415285499	132	E>G		No	ClinGen TOPMed
TCGA novel	134	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1556842930 CA415285411	140	E>G		No	ClinGen gnomAD
TCGA novel	148	E>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA337606892 rs934784833	149	A>T		No	ClinGen gnomAD
CA415284804 rs1556842817	151	R>Q		No	ClinGen gnomAD
rs375367118 CA10544572	158	S>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10544571 rs373398188	164	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs782369762 CA10544570	164	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed
rs782015059 CA10544568	166	M>I		No	ClinGen ExAC gnomAD
CA10544567 rs782320131	168	K>N		No	ClinGen ExAC gnomAD
CA415284618 rs1556842810	168	K>T		No	ClinGen gnomAD
CA10544566 rs200629354	169	T>P		No	ClinGen ExAC TOPMed gnomAD
rs200629354 CA415284609	169	T>S		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with P41208

5 regional properties for P41208

Type	Name	Position	InterPro Accession
conserved_site	ATP-dependent RNA helicase DEAD-box, conserved site	145 - 153	IPR000629
domain	EF-hand domain	28 - 99	IPR002048-1
domain	EF-hand domain	101 - 172	IPR002048-2
binding_site	EF-Hand 1, calcium-binding site	41 - 53	IPR018247-1
binding_site	EF-Hand 1, calcium-binding site	150 - 162	IPR018247-2

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Nucleus envelope Nucleus, nuclear pore complex Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
9+2 motile cilium	A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
apical part of cell	The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
centriole	A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
ciliary basal body	A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear pore nuclear basket	A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
photoreceptor connecting cilium	The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.
transcription export complex 2	A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p.
XPC complex	A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2.

4 GO annotations of molecular function

Name	Definition
calcium ion binding	Binding to a calcium ion (Ca2+).
G-protein beta/gamma-subunit complex binding	Binding to a complex of G-protein beta/gamma subunits.
heterotrimeric G-protein binding	Binding to a heterotrimeric G-protein.
microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.

8 GO annotations of biological process

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
centriole replication	The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nucleotide-excision repair	A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of cytokinesis	Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9R1K9	Cetn2	Centrin-2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MASNFKKANM	ASSSQRKRMS	PKPELTEEQK	QEIREAFDLF	DADGTGTIDV	KELKVAMRAL
70	80	90	100	110	120
GFEPKKEEIK	KMISEIDKEG	TGKMNFGDFL	TVMTQKMSEK	DTKEEILKAF	KLFDDDETGK
130	140	150	160	170
ISFKNLKRVA	KELGENLTDE	ELQEMIDEAD	RDGDGEVSEQ	EFLRIMKKTS	LY