Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P40361

Entry ID Method Resolution Chain Position Source
AF-P40361-F1 Predicted AlphaFoldDB

21 variants for P40361

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-310547 29 E>G No SGRP
s10-310514 40 V>A No SGRP
s10-310515 40 V>F No SGRP
s10-310493 47 Q>R No SGRP
s10-310452 61 P>S No SGRP
s10-310182 151 D>N No SGRP
s10-310100 178 S>F No SGRP
s10-309995 213 Y>C No SGRP
s10-309485 383 S>N No SGRP
s10-309353 427 N>S No SGRP
s10-309338 432 L>S No SGRP
s10-309322 437 M>I No SGRP
s10-309324 437 M>V No SGRP
s10-309234 467 I>V No SGRP
s10-308822 604 G>A No SGRP
s10-308676 653 V>M No SGRP
s10-308481 718 L>V No SGRP
s10-308150 828 G>V No SGRP
s10-308127 836 E>K No SGRP
s10-308085 850 K>E No SGRP
s10-308057 859 P>L No SGRP

No associated diseases with P40361

6 regional properties for P40361

Type Name Position InterPro Accession
domain HIT-like domain 182 - 287 IPR011146
domain Zinc finger C2H2-type 333 - 353 IPR013087
conserved_site Histidine triad, conserved site 261 - 279 IPR019808
domain Aprataxin, C2HE/C2H2/C2HC zinc finger 297 - 356 IPR032566
domain PNK, FHA domain 19 - 115 IPR041388
domain Aprataxin, forkhead associated domain 17 - 116 IPR047289

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
organic cyclic compound metabolic process The chemical reactions and pathways involving organic cyclic compound.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q01432 AMPD3 AMP deaminase 3 Homo sapiens (Human) PR
O08739 Ampd3 AMP deaminase 3 Mus musculus (Mouse) PR
10 20 30 40 50 60
MQAVERRPSL LFDEYQNSVT KPNETKNKEA RVLSENDGDV SPSVLKQKEI SVDDMDMISL
70 80 90 100 110 120
PTEFDRQMVL GSPMFFDLED EENKIDPLPS VSHHYGNGES DSFVSSYTPS NLKTGEETKD
130 140 150 160 170 180
LFINPFELVS QMRKRYIAAS KQDGISNIKN DTEKWFLYPK PLPKFWRFED DKRFQDPSDS
190 200 210 220 230 240
DLNDDGDSTG TGAATPHRHG YYYPSYFTDH YYYYTKSGLK GKGNIKVPYT GEYFDLEDYK
250 260 270 280 290 300
KQYIYHLSNQ ENTQNPLSPY SSKEESLEEE FLTDVPTFQE FRDDFAYIIE LIQSHKFNEV
310 320 330 340 350 360
SRKRLSYLLD KFELFQYLNS KKEILANKNV PYRDFYNSRK VDRDLSLSGC ISQRQLSEYI
370 380 390 400 410 420
WEKINLEPER IVYQDPETSR KLSLRDIFQF GCSSNDQPIA IGLKLIDDEF LDWYRNIYLI
430 440 450 460 470 480
DYHLTPNKVA KLVGKEMRFY LLAKVFLEFD NFIEGEYLAE IFIKYVIHIL EKSKYQLAQV
490 500 510 520 530 540
SVNFQFYSSG EDWYKKFSQW LLRWKLVSYN IRWNIQIARI FPKLFKENVV SNFQEFLDLI
550 560 570 580 590 600
FNPLFTLEKE QLPIDSSVNT DIIGLQFFLS NVCSMDLVIK ESDEYYWKEF TDMNCKPKFW
610 620 630 640 650 660
TAQGDNPTVA HYMYYIYKSL AKVNFLRSQN LQNTITLRNY CSPLSSRTSQ FGVDLYFTDQ
670 680 690 700 710 720
VESLVCNLLL CNGGLLQVEP LWDTATMIQY LFYLFQIPIL AAPLSSVSLL NSQKSTFLKN
730 740 750 760 770 780
KNVLLEHDYL KDQETAKINP SRDITVGEQR SYETNPFMKM FKMGLKISLS SKSILYNSSY
790 800 810 820 830 840
TLEPLIEEYS VAASIYLLNP TDLCELSRTS VLSSGYEGWY KAHWIGVGVK KAPYFEENVG
850 860 870 880
GIDNWYDTAK DTSIKHNVPM IRRRYRKETL DQEWNFVRDH FGVINSIW