O08739
Gene name |
Ampd3 |
Protein name |
AMP deaminase 3 |
Names |
AMP deaminase H-type, AMP deaminase isoform E, Heart-type AMPD |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:11717 |
EC number |
3.5.4.6: In cyclic amidines |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O08739
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O08739-F1 | Predicted | AlphaFoldDB |
32 variants for O08739
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388937743 | 2 | P>L | No | EVA | |
| rs219786764 | 16 | H>Q | No | EVA | |
| rs3388918899 | 53 | E>V | No | EVA | |
| rs3388942112 | 64 | A>V | No | EVA | |
| rs3388937738 | 66 | Q>R | No | EVA | |
| rs3388936689 | 92 | T>I | No | EVA | |
| rs3388937883 | 100 | P>R | No | EVA | |
| rs3388937715 | 151 | A>T | No | EVA | |
| rs3388941980 | 173 | F>L | No | EVA | |
| rs3388942076 | 224 | H>Y | No | EVA | |
| rs3388940557 | 226 | G>C | No | EVA | |
| rs37336329 | 236 | M>L | No | EVA | |
| rs3388931691 | 244 | S>I | No | EVA | |
| rs3388934057 | 301 | S>N | No | EVA | |
| rs3388937917 | 320 | A>V | No | EVA | |
| rs264435760 | 351 | K>N | No | EVA | |
| rs3388918914 | 381 | T>I | No | EVA | |
| rs3388940691 | 398 | S>R | No | EVA | |
| rs3388942023 | 399 | E>D | No | EVA | |
| rs3412850413 | 420 | V>D | No | EVA | |
| rs3388918909 | 421 | K>M | No | EVA | |
| rs3388934008 | 470 | I>F | No | EVA | |
| rs3388934008 | 470 | I>V | No | EVA | |
| rs3388936652 | 497 | L>M | No | EVA | |
| rs3388936646 | 542 | S>N | No | EVA | |
| rs3388918901 | 547 | T>S | No | EVA | |
| rs3388918944 | 550 | Q>R | No | EVA | |
| rs261773293 | 578 | S>N | No | EVA | |
| rs3388937928 | 605 | I>M | No | EVA | |
| rs3388933990 | 675 | M>T | No | EVA | |
| rs3388937721 | 759 | E>V | No | EVA | |
| rs3388910882 | 767 | K>Y | No | EVA |
No associated diseases with O08739
6 regional properties for O08739
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Tetratricopeptide repeat | 43 - 76 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 138 - 171 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 212 - 245 | IPR019734-3 |
| repeat | Tetratricopeptide repeat | 246 - 279 | IPR019734-4 |
| repeat | Tetratricopeptide repeat | 347 - 380 | IPR019734-5 |
| repeat | Tetratricopeptide repeat | 482 - 515 | IPR019734-6 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.5.4.6 | In cyclic amidines |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| AMP deaminase activity | Catalysis of the reaction: AMP + H2O = IMP + NH3. |
| metal ion binding | Binding to a metal ion. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| ADP catabolic process | The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate. |
| ADP metabolic process | The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. |
| AMP catabolic process | The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate. |
| AMP metabolic process | The chemical reactions and pathways involving AMP, adenosine monophosphate. |
| ATP metabolic process | The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. |
| energy homeostasis | Any process involved in the balance between food intake (energy input) and energy expenditure. |
| erythrocyte homeostasis | Any process of regulating the production and elimination of erythrocytes within an organism. |
| GTP metabolic process | The chemical reactions and pathways involving GTP, guanosine triphosphate. |
| IMP biosynthetic process | The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. |
| IMP salvage | Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPRQFPKLNM | SDLDEHVRLL | AEKVFAKVLR | EEDSKDVMSL | FTVPEDCPIG | QKEAKERELQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KELAEQKSVE | TAKRKKSFKM | IRSQSLSLQM | PTQQDWKGPP | TASPAMSPAT | PLVPGATSKP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GPAPYAMPEY | QRVTISGDYC | AGITVEDYEQ | AAKSLAKALM | IREKYARLAY | HRFPRTTAQY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAHQGESVPL | EEGLPDFHPP | PLPQEDPYCL | DDAPPNLGYL | VRMHGGVLFV | YDNQTMLERQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EPHSLPYPDL | ETYIVDMSHI | LALITDGPTK | TYCHRRLNFL | ESKFSLHEML | NEMSEFKELK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SNPHRDFYNV | RKVDTHIHAA | ACMNQKHLLR | FIKHTYQTEP | DRTVAEKLGR | KITLRQVFDS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LHMDPYDLTV | DSLDVHAGRQ | TFHRFDKFNS | KYNPVGASEL | RDLYLKTENY | LGGEYFARMV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KEVARELEDS | KYQYSEPRLS | IYGRSPKEWS | SLARWFIQHK | VYSPNMRWII | QVPRIYDIFR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SKKLLPNFGK | MLENIFLPLF | KATINPQDHR | ELHLFLKYVT | GFDSVDDESK | HSDHMFSDKS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PSPDLWTSEQ | NPPYSYYLYY | MYANIMVLNN | LRRERGLSTF | LFRPHCGEAG | SITHLVSAFL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TADNISHGLL | LKKSPVLQYL | YYLAQIPIAM | SPLSNNSLFL | EYSKNPLREF | LHKGLHVSLS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TDDPMQFHYT | KEALMEEYAI | AAQVWKLSTC | DLCEIARNSV | LQSGLSHQEK | QKFLGQNYYK |
| 730 | 740 | 750 | 760 | ||
| EGPEGNDIRK | TNVAQIRMAF | RYETLCNELS | FLSDAMKSEE | ITALTK |