P39719
Gene name |
FLC2 (YAL053W) |
Protein name |
Flavin carrier protein 2 |
Names |
FAD transporter 2, TRP-like ion channel FLC2 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YAL053W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P39719
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P39719-F1 | Predicted | AlphaFoldDB |
10 variants for P39719
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s01-45913 | 5 | N>S | No | SGRP | |
| s01-45945 | 16 | V>I | No | SGRP | |
| s01-45960 | 21 | T>A | No | SGRP | |
| s01-45967 | 23 | R>H | No | SGRP | |
| s01-46376 | 159 | E>D | No | SGRP | |
| s01-46380 | 161 | E>Q | No | SGRP | |
| s01-46673 | 258 | N>K | No | SGRP | |
| s01-46815 | 306 | T>S | No | SGRP | |
| s01-48055 | 719 | G>D | No | SGRP | |
| s01-48115 | 739 | A>G | No | SGRP |
No associated diseases with P39719
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| FAD transmembrane transporter activity | Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. |
| cellular hypotonic response | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. |
| FAD transport | The directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. |
| fungal-type cell wall biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| sphingolipid biosynthetic process | The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). |
| transmembrane transport | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. |
2 homologous proteins in AiPD
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIFLNTFARC | LLTCFVLCSG | TARSSDTNDT | TPASAKHLQT | TSLLTCMDNS | QLTASFFDVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FYPDNNTVIF | DIDATTTLNG | NVTVKAELLT | YGLKVLDKTF | DLCSLGQVSL | CPLSAGRIDV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MSTQVIESSI | TKQFPGIAYT | IPDLDAQVRV | VAYAQNDTEF | ETPLACVQAI | LSNGKTVQTK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YAAWPIAAIS | GVGVLTSGFV | SVIGYSATAA | HIASNSISLF | IYFQNLAITA | MMGVSRVPPI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AAAWTQNFQW | SMGIINTNFM | QKIFDWYVQA | TNGVSNVVVA | NKDVLSISVQ | KRAISMASSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DYNFDTILDD | SNLYTTSEKD | PSNYSAKILV | LRGIERVAYL | ANIELSNFFL | TGIVFFLFFL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FVVVVSLIFF | KALLEVLTRA | RILKETSNFF | QYRKNWGSII | KGTLFRLSII | AFPQVSLLAI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WEFTQVNSPA | IVVDAVVILL | IITGLLVYGT | IRVFIKGRES | LRLYKNPAYL | LYSDTYFLNK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FGFLYVQFKA | DKFWWLLPLL | SYAFLRSLFV | AVLQNQGKAQ | AMIIFVIELA | YFVCLCWIRP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YLDKRTNVFN | IAIHLVNLIN | AFFFLFFSNL | FKQPAVVSSV | MAVILFVLNA | VFALFLLLFT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IVTCTLALLH | RNPDVRYQPM | KDDRVSFIPK | IQNDFDGKNK | NDSELFELRK | AVMDTNENEE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EKMFRDDTFG | KNLNANTNTA | RLFDDETSSS | SFKQNSSPFD | ASEVTEQPVQ | PTSAVMGTGG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SFLSPQYQRA | SSASRTNLAP | NNTSTSSLMK | PESSLYLGNS | NKSYSHFNNN | GSNENARNNN |
| PYL |