P39531

PR
Gene name
RCY1 (YJL204C, J0318, J0320)
Protein name
Recyclin-1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJL204C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

396-510 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P39531

Entry ID Method Resolution Chain Position Source
AF-P39531-F1 Predicted AlphaFoldDB

14 variants for P39531

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-52932 74 N>D No SGRP
s10-52931 74 N>S No SGRP
s10-52905 83 I>L No SGRP
s10-52905 83 I>V No SGRP
s10-52870 94 K>N No SGRP
s10-52869 95 I>V No SGRP
s10-52757 132 R>K No SGRP
s10-52454 233 E>G No SGRP
s10-52127 342 F>Y No SGRP
s10-52036 372 L>F No SGRP
s10-51927 409 S>G No SGRP
s10-51798 452 D>N No SGRP
s10-51599 518 H>R No SGRP
s10-51509 548 K>R No SGRP

No associated diseases with P39531

No regional properties for P39531

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P39531

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Bud neck
  • Cell tip
  • In unpolarized G1 cells this protein is found in patches in the cytoplasm, while after bud emergence it is concentrated in nascent buds and at the mother-bud neck
  • Accumulates at the shmoo tips of cells treated with pheromone
  • Localization depends on an intact actin cytoskeleton and a functional secretory pathway
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cell tip The region at the end of the longest axis of a cylindrical or elongated cell.
cellular bud A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated.
cellular bud neck The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome A vacuole to which materials ingested by endocytosis are delivered.
exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
site of polarized growth Any part of a cell where non-isotropic growth takes place.

1 GO annotations of molecular function

Name Definition
SNARE binding Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.

6 GO annotations of biological process

Name Definition
early endosome to Golgi transport The directed movement of substances from early endosomes to the Golgi.
endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P97878 Exoc5 Exocyst complex component 5 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDDLLKVPEI VTNIASYLST VDYLSFQQVN KRVYAIINGK NDSKYWSLKL TRMGLQQVHS
70 80 90 100 110 120
NEEEEITLLD ENDNQNSLRI FEIYKSFTAQ NSKKIFVKFY RCYNSYARKL YNNNLANFFP
130 140 150 160 170 180
TSYSNDPLKQ TRILNFIKKY NFSNKNDIET FTRIETNFNI LREIFINSVL KESELNYQSN
190 200 210 220 230 240
NLAAVARFMK ILLISNEESN AIEFFKSKAD LPPSLTVLPS NDELFWAEQP REEDSGGSTV
250 260 270 280 290 300
IFNSKNLDTF LNQLRDFLNE KIKLADILFK DEFPVILQFI ESFIQDILLD ILNNILLSYS
310 320 330 340 350 360
EFLKENGKDS KANYECVPEL YFTFIKKFDT ELNDSVNAGA NFRKVVRDLL NLYLEPFVVN
370 380 390 400 410 420
YMNQTTRVFE SLINSQLANY DTQVQDKQRE QNAKIYNTLK DQTDASSASN NELPNDLSII
430 440 450 460 470 480
TETSKTVPEA DSKPSTIHQS VHSTDISNDK LDFLSSFTKI FKFSNNENQR LKQQLQLAYN
490 500 510 520 530 540
LNLISNNLQN IKSLISLDLC YKILQETSEK TDQIYKFHTI ESLLPLIKLR CQEIFKILIT
550 560 570 580 590 600
QLNKNHVKPA FEKAILLLQK YNPNEIEQIE IKFNSLSPAN TQVEPLVQFT ELINIGDIIL
610 620 630 640 650 660
QMISIFYKNE LIPKKIIDKN KDFLNDVIQL KKNFETSIDD FVAEGLNIGI NKLMDEISFV
670 680 690 700 710 720
FKTLQLPDDY NPPPPSRNSP IRDIKPTKCA IRVVELLSNH CFLLTGATDK GTIDVYQQEI
730 740 750 760 770 780
GERFFNEIVK HLKKCFISTE GAIWLICDLN YFYDFIANKL KQKNVVPYFV GLKSIGQLYI
790 800 810 820 830
ISGKDSKELG KLISDLGKFN GIFTQEEIYE FVQRRSDWVR VRKDVEKVMY GLGIRDCCIM