AiPD: Autoinhibited Protein Database

P39023

Gene name	RPL3 (OK/SW-cl.32)
Protein name	60S ribosomal protein L3
Names	HIV-1 TAR RNA-binding protein B, TARBP-B, Large ribosomal subunit protein uL3
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6122
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-50 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

94 structures for P39023

Entry ID	Method	Resolution	Chain	Position	Source
4UG0	EM	-	LB	1-403	PDB
4V6X	EM	500 A	CB	1-403	PDB
5AJ0	EM	350 A	AB	1-403	PDB
5LKS	EM	360 A	LB	1-403	PDB
5T2C	EM	360 A	E	1-403	PDB
6IP5	EM	390 A	1E	1-403	PDB
6IP6	EM	450 A	1E	1-403	PDB
6IP8	EM	390 A	1E	1-403	PDB
6LQM	EM	309 A	B	1-403	PDB
6LSR	EM	313 A	B	1-403	PDB
6LSS	EM	323 A	B	1-403	PDB
6LU8	EM	313 A	B	1-403	PDB
6OLE	EM	310 A	B	2-398	PDB
6OLF	EM	390 A	B	2-398	PDB
6OLG	EM	340 A	AB	2-395	PDB
6OLI	EM	350 A	B	2-398	PDB
6OLZ	EM	390 A	AB	2-395	PDB
6OM0	EM	310 A	B	2-398	PDB
6OM7	EM	370 A	B	2-398	PDB
6QZP	EM	290 A	LB	2-403	PDB
6W6L	EM	384 A	B	1-403	PDB
6XA1	EM	280 A	LB	2-397	PDB
6Y0G	EM	320 A	LB	1-403	PDB
6Y2L	EM	300 A	LB	1-403	PDB
6Y57	EM	350 A	LB	1-403	PDB
6Y6X	EM	280 A	LB	2-398	PDB
6Z6L	EM	300 A	LB	1-403	PDB
6Z6M	EM	310 A	LB	1-403	PDB
6Z6N	EM	290 A	LB	1-403	PDB
6ZM7	EM	270 A	LB	1-403	PDB
6ZME	EM	300 A	LB	1-403	PDB
6ZMI	EM	260 A	LB	1-403	PDB
6ZMO	EM	310 A	LB	1-403	PDB
7BHP	EM	330 A	LB	1-403	PDB
7F5S	EM	272 A	LB	1-403	PDB
7QVP	EM	300 A	LB/MB	1-403	PDB
7XNX	EM	270 A	LB	1-403	PDB
7XNY	EM	250 A	LB	1-403	PDB
8A3D	EM	167 A	E	1-403	PDB
8FKP	EM	285 A	LN	1-403	PDB
8FKQ	EM	276 A	LN	1-403	PDB
8FKR	EM	289 A	LN	1-403	PDB
8FKS	EM	288 A	LN	1-403	PDB
8FKT	EM	281 A	LN	1-403	PDB
8FKU	EM	282 A	LN	1-403	PDB
8FKV	EM	247 A	LN	1-403	PDB
8FKW	EM	250 A	LN	1-403	PDB
8FKX	EM	259 A	LN	1-403	PDB
8FKY	EM	267 A	LN	1-403	PDB
8FKZ	EM	304 A	LN	1-403	PDB
8FL0	EM	291 A	LN	1-403	PDB
8FL2	EM	267 A	LN	1-403	PDB
8FL3	EM	253 A	LN	1-403	PDB
8FL4	EM	289 A	LN	1-403	PDB
8FL6	EM	262 A	LN	1-403	PDB
8FL7	EM	255 A	LN	1-403	PDB
8FL9	EM	275 A	LN	1-403	PDB
8FLA	EM	263 A	LN	1-403	PDB
8FLB	EM	255 A	LN	1-403	PDB
8FLC	EM	276 A	LN	1-403	PDB
8FLD	EM	258 A	LN	1-403	PDB
8FLE	EM	248 A	LN	1-403	PDB
8FLF	EM	265 A	LN	1-403	PDB
8G5Y	EM	229 A	LB	1-403	PDB
8G5Z	EM	264 A	LB	2-403	PDB
8G60	EM	254 A	LB	1-403	PDB
8G61	EM	294 A	LB	1-403	PDB
8G6J	EM	280 A	LB	1-403	PDB
8GLP	EM	167 A	LB	1-403	PDB
8IDT	EM	280 A	B	1-403	PDB
8IDY	EM	300 A	B	1-403	PDB
8IE3	EM	330 A	B	1-403	PDB
8IFD	EM	259 A	1E	1-403	PDB
8IFE	EM	257 A	1E	1-403	PDB
8INE	EM	320 A	B	1-403	PDB
8INF	EM	300 A	B	1-403	PDB
8INK	EM	320 A	B	1-403	PDB
8IPD	EM	320 A	B	1-403	PDB
8IPX	EM	430 A	B	1-403	PDB
8IPY	EM	320 A	B	1-403	PDB
8IR1	EM	330 A	B	1-403	PDB
8IR3	EM	350 A	B	1-403	PDB
8JDJ	EM	250 A	H	1-403	PDB
8JDK	EM	226 A	H	1-403	PDB
8JDL	EM	242 A	H	1-403	PDB
8JDM	EM	267 A	H	1-403	PDB
8OHD	EM	310 A	LB	1-403	PDB
8OJ0	EM	330 A	LB	1-403	PDB
8OJ5	EM	290 A	LB	1-403	PDB
8OJ8	EM	330 A	LB	1-403	PDB
8QFD	EM	220 A	B	1-403	PDB
8Y0W	EM	340 A	LB	1-403	PDB
8Y0X	EM	330 A	LB	1-403	PDB
AF-P39023-F1	Predicted				AlphaFoldDB

310 variants for P39023

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA411609264 rs1253031184	8	A>V		No	ClinGen gnomAD
CA411609258 rs1601632116	9	P>S		No	ClinGen Ensembl
rs1569162425 CA411609230 VAR_069220	11	H>R	rare variant found in a Diamond-Blackfan anemia patient; unknown pathological significance [UniProt]	No	ClinGen UniProt Ensembl dbSNP
TCGA novel	11	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1418605660 CA411609206	13	S>A		No	ClinGen TOPMed
rs1209796975 CA411609202	13	S>C		No	ClinGen TOPMed gnomAD
TCGA novel	13	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411609164 rs1280990343	16	F>Y		No	ClinGen gnomAD
CA10240989 rs571697433	17	L>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs1328546171 CA411609136	19	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10240988 rs766573671	20	K>N		No	ClinGen ExAC gnomAD
rs894074709 CA324387206	21	R>C		No	ClinGen Ensembl
CA411609102 rs1226525772	21	R>H		No	ClinGen gnomAD
CA411609096 rs1307445766	22	S>G		No	ClinGen gnomAD
rs1446936360 CA411609070	23	S>R		No	ClinGen gnomAD
rs773204963 CA10240986	23	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1357140249 CA411609044	25	H>R		No	ClinGen gnomAD
CA10240985 rs145471270	26	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1339276139 CA411609031	26	R>L		No	ClinGen TOPMed
rs1450752948 CA411609011	28	K>R		No	ClinGen TOPMed
rs1601632056 CA411608994	29	V>G		No	ClinGen Ensembl
rs140036416 CA324387169	29	V>L		No	ClinGen ESP gnomAD
CA411608967 rs1156266825	31	S>I		No	ClinGen TOPMed gnomAD
CA411608968 rs1156266825	31	S>T		No	ClinGen TOPMed gnomAD
CA411608955 rs1181709262	33	P>A		No	ClinGen gnomAD
rs1472005805 CA411608951	33	P>R		No	ClinGen gnomAD
rs1276314789 CA411608938	35	D>G		No	ClinGen gnomAD
rs1204512463 CA411608931	36	D>A		No	ClinGen gnomAD
rs1204512463 CA411608929	36	D>V		No	ClinGen gnomAD
CA411608925 rs1266337271	37	P>A		No	ClinGen gnomAD
rs147933419 CA10240979	37	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA411608924 rs1266337271	37	P>S		No	ClinGen gnomAD
CA411608910 rs1227595225	39	K>M		No	ClinGen gnomAD
rs1189932542 CA411608902	40	P>L		No	ClinGen TOPMed
CA411608907 rs1569162347	40	P>S		No	ClinGen Ensembl
CA324387158 rs11548027	42	H>N		No	ClinGen TOPMed gnomAD
rs11547990 CA324387154	42	H>R		No	ClinGen Ensembl
CA411608894 rs11548027	42	H>Y		No	ClinGen TOPMed gnomAD
rs1363950331 CA411608887	43	L>F		No	ClinGen TOPMed gnomAD
rs11547982 CA324387148	43	L>R		No	ClinGen Ensembl
rs141020322 CA10240975	44	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	44	T>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1346365343 CA411608876	45	A>G		No	ClinGen gnomAD
TCGA novel	45	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1346365343 CA411608874	45	A>V		No	ClinGen gnomAD
CA10240973 rs755320413	46	F>L		No	ClinGen ExAC gnomAD
rs11547969 CA324387112	47	L>V		No	ClinGen Ensembl
CA411608852 rs1403992247	49	Y>C		No	ClinGen gnomAD
rs1184536991 CA411608839	51	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA324387100 rs11547980	51	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1157762489 CA411608835	52	G>S		No	ClinGen gnomAD
CA10240971 rs758711018	53	M>L		No	ClinGen ExAC gnomAD
rs758711018 CA10240970	53	M>V		No	ClinGen ExAC gnomAD
CA10240969 rs150700689	54	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1426099487 CA411608808	56	I>V		No	ClinGen gnomAD
rs927094974 CA324387083	57	V>M		No	ClinGen TOPMed
rs1486229037 CA411608796	58	R>W		No	ClinGen gnomAD
CA10240967 rs761853326	61	D>Y		No	ClinGen ExAC gnomAD
CA324387056 rs991107846	62	R>M		No	ClinGen Ensembl
CA324387060 rs920511672	62	R>W		No	ClinGen Ensembl
rs11547989 CA324387054	63	P>L		No	ClinGen Ensembl
rs1207487016 CA411608681 CA411608680	67	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen gnomAD NCI-TCGA
CA10240924 rs567535132	69	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs757405581 CA10240923	71	E>D		No	ClinGen ExAC gnomAD
CA324384358 rs936506571	74	E>V		No	ClinGen TOPMed
rs777968901 CA10240921	75	A>T		No	ClinGen ExAC gnomAD
rs11548018 CA324384345	77	T>A		No	ClinGen Ensembl
rs1392261719 CA411608610	78	I>V		No	ClinGen gnomAD
rs1278199198 CA411608604	79	V>I		No	ClinGen TOPMed gnomAD
CA10240919 rs752710485	80	E>D		No	ClinGen ExAC gnomAD
rs11089942 CA324384330	82	P>L		No	ClinGen Ensembl
CA324384335 rs11089942	82	P>Q		No	ClinGen Ensembl
CA10240918 rs767306098	82	P>S		No	ClinGen ExAC TOPMed gnomAD
CA411608585 rs767306098	82	P>T		No	ClinGen ExAC TOPMed gnomAD
CA411608579 rs1467682617	83	P>L		No	ClinGen TOPMed gnomAD
CA411608578 rs1467682617	83	P>R		No	ClinGen TOPMed gnomAD
CA10240917 rs374869361	86	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA324384327 rs11547999	87	V>A		No	ClinGen Ensembl
rs1601631030 CA411608543	89	I>V		No	ClinGen Ensembl
rs1391826398 CA411608533	90	V>A		No	ClinGen TOPMed
rs1569161735 CA411608521	92	Y>C		No	ClinGen Ensembl
TCGA novel	93	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs373347667 CA411608516	93	V>L		No	ClinGen ESP TOPMed gnomAD
rs373347667 CA324384314	93	V>M		No	ClinGen ESP TOPMed gnomAD
rs1380416261 CA411608494	96	P>R		No	ClinGen TOPMed
CA10240915 rs766268646	97	R>Q		No	ClinGen ExAC gnomAD
rs1360637183 CA411608485	98	G>D		No	ClinGen gnomAD
TCGA novel	99	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1297822123 CA411608481	99	L>V		No	ClinGen TOPMed
CA324384310 rs11548021	100	R>Q		No	ClinGen Ensembl
rs944158460 CA324384312	100	R>W		No	ClinGen TOPMed gnomAD
rs1462350363 CA411608468	101	T>I		No	ClinGen TOPMed gnomAD
CA10240914 rs762747907	102	F>L		No	ClinGen ExAC gnomAD
CA10240913 rs772715706	102	F>Y		No	ClinGen ExAC gnomAD
CA411608457 rs1412915784	103	K>R		No	ClinGen gnomAD
rs11547978 CA324384302	104	T>I		No	ClinGen gnomAD
CA10240912 rs537226617	105	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1310975500 CA411608438	106	F>C		No	ClinGen TOPMed gnomAD
CA411608430 rs1454801137	107	A>V		No	ClinGen gnomAD
CA324384292 rs11548026	111	S>N		No	ClinGen Ensembl
rs746239064 CA10240909	112	D>E		No	ClinGen ExAC TOPMed gnomAD
CA411608386 rs774765796	113	E>D		No	ClinGen ExAC gnomAD
rs1207347334 CA411608372	115	K>R		No	ClinGen TOPMed
rs11547984 CA324384279	117	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs11547984 CA324384283	117	R>G		No	ClinGen TOPMed
rs11548030 CA324384275	117	R>H		No	ClinGen TOPMed gnomAD
rs11548030 CA411608359	117	R>L		No	ClinGen TOPMed gnomAD
rs148616680 CA324384264	118	F>L		No	ClinGen ESP
CA10240906 rs771273075	118	F>S		No	ClinGen ExAC TOPMed gnomAD
rs771273075 CA411608355	118	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs749575721 CA10240905	119	Y>C		No	ClinGen ExAC gnomAD
rs920177617 CA324384259	120	K>E		No	ClinGen gnomAD
CA10240903 rs756238786	121	N>K		No	ClinGen ExAC gnomAD
CA10240904 rs763878182	121	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1601630146 CA411608307	123	H>R		No	ClinGen Ensembl
rs774179454 CA10240822	124	K>N		No	ClinGen ExAC gnomAD
CA411608283 rs1384159067	126	K>N		No	ClinGen TOPMed
rs770832833 CA411608279	127	K>R		No	ClinGen ExAC gnomAD
rs770832833 CA10240820	127	K>T		No	ClinGen ExAC gnomAD
CA324383637 rs986461895	128	K>E		No	ClinGen Ensembl
TCGA novel	128	K>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs749217947 CA10240819	129	A>V		No	ClinGen ExAC gnomAD
rs1601630120 CA411608254	131	T>S		No	ClinGen Ensembl
CA324383633 rs955307948	133	Y>C		No	ClinGen TOPMed
CA411608239 rs1569161165	133	Y>D		No	ClinGen Ensembl
CA411608232 rs1164416539	134	C>G		No	ClinGen TOPMed gnomAD
CA411608233 rs1164416539	134	C>R		No	ClinGen TOPMed gnomAD
CA411608231 rs1449046962	134	C>Y		No	ClinGen gnomAD
CA411608202 rs1417486220	137	W>C		No	ClinGen gnomAD
rs982612705 CA324383630	139	D>H		No	ClinGen TOPMed
rs1569161150 CA411608176	141	D>N		No	ClinGen Ensembl
rs769554769 CA10240817	143	K>R		No	ClinGen ExAC
rs143911448 CA10240816	144	K>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142465478 CA324383616	144	K>R		No	ClinGen ESP
CA411608146 rs1242628914	145	Q>L		No	ClinGen gnomAD
rs11547987 CA10240814	148	K>E		No	ClinGen ExAC TOPMed gnomAD
CA10240813 rs746467330	148	K>R		No	ClinGen ExAC gnomAD
rs1246303095 CA411608122	149	D>Y		No	ClinGen gnomAD
CA10240811 rs757909506	150	F>L		No	ClinGen ExAC gnomAD
rs1215807418 CA411608108	151	S>G		No	ClinGen gnomAD
CA324383578 rs11266894 CA10240809	153	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA411608092 rs1293430794	153	M>V		No	ClinGen TOPMed gnomAD
rs1367883623 CA411608077	155	K>E		No	ClinGen gnomAD
CA10240808 rs756516253	155	K>N		No	ClinGen ExAC gnomAD
rs1017030830 CA324383565	156	Y>H		No	ClinGen Ensembl
rs1352914759 CA411608061	157	C>Y		No	ClinGen gnomAD
CA10240804 rs751726139	159	V>G		No	ClinGen ExAC gnomAD
rs145447314 CA10240805	159	V>I		No	ClinGen ESP ExAC gnomAD
TCGA novel	160	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762926536 CA10240802	160	I>V		No	ClinGen ExAC gnomAD
rs1186848404 CA411608036	161	R>C		No	ClinGen TOPMed
CA10240801 rs141775550	161	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	161	R>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411608015 rs1165201963	164	A>V		No	ClinGen TOPMed
CA411608003 rs1480142570	166	T>N		No	ClinGen gnomAD
rs1002052109 CA324383539	167	Q>R		No	ClinGen TOPMed
CA10240769 rs531733121	169	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA10240768 rs755263201	169	R>H		No	ClinGen ExAC TOPMed gnomAD
CA411607712 rs1285392059	173	L>P		No	ClinGen Ensembl
rs150171464 CA324382543	174	R>C		No	ClinGen ESP TOPMed gnomAD
rs780201245 COSM1190454 CA10240766	174	R>H	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA411607702 rs1569160445	175	Q>R		No	ClinGen Ensembl
rs758485930 CA411607690	177	K>E		No	ClinGen ExAC gnomAD
CA10240765 rs758485930	177	K>Q		No	ClinGen ExAC gnomAD
rs1262882764 CA411607688	177	K>T		No	ClinGen gnomAD
CA411607673 rs1359062167	179	H>L		No	ClinGen gnomAD
CA10240764 rs750433888	179	H>N		No	ClinGen ExAC TOPMed gnomAD
CA411607676 rs750433888	179	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA10240763 rs140921052	180	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA324382521 rs11548008	182	E>*		No	ClinGen Ensembl
rs1398523387 CA411607648	183	I>F		No	ClinGen TOPMed
rs1383656269 CA411607644	183	I>M		No	ClinGen gnomAD
rs1382608842 CA411607621	187	G>R		No	ClinGen gnomAD
rs147052334 CA324382517	188	G>C		No	ClinGen ESP
CA411607610 rs1384280244	189	T>P		No	ClinGen gnomAD
rs1042310524 CA324382515	192	E>D		No	ClinGen TOPMed
CA324382516 rs199861421	192	E>K		No	ClinGen TOPMed gnomAD
rs759124347 CA411607577	194	L>V		No	ClinGen ExAC gnomAD
CA411607567 rs1253611316	195	D>E		No	ClinGen TOPMed
rs1340599767 CA411607556	197	A>T		No	ClinGen TOPMed
CA10240755 rs774059903	198	R>C		No	ClinGen ExAC TOPMed gnomAD
CA324382508 rs947533855	198	R>H		No	ClinGen TOPMed gnomAD
rs748725995 CA10240753	199	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA324382496 rs879141639	202	E>*		No	ClinGen gnomAD
CA411607506 rs1477404214	204	Q>R		No	ClinGen TOPMed
rs747315650 CA10240750	205	V>G		No	ClinGen ExAC gnomAD
rs769088048 CA10240751	205	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1324677315 CA411607483	208	N>S		No	ClinGen gnomAD
CA411607473 rs1400427370	209	Q>H		No	ClinGen gnomAD
rs780258126 CA10240749	210	V>G		No	ClinGen ExAC TOPMed gnomAD
CA10240747 rs373627673	211	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA411607428 rs1426181023	216	M>V		No	ClinGen gnomAD
CA10240746 rs779014473	217	I>F		No	ClinGen ExAC gnomAD
rs1404474101 CA411607414	218	D>N		No	ClinGen TOPMed gnomAD
CA10240744 rs753846029	219	V>I		No	ClinGen ExAC gnomAD
rs763893113 CA10240743	220	I>V		No	ClinGen ExAC gnomAD
rs943345187 CA324382468	222	V>M		No	ClinGen TOPMed
CA10240740 rs767419146	224	K>E		No	ClinGen ExAC gnomAD
rs11548001 CA10240739	226	K>E		No	ClinGen ExAC gnomAD
CA324382467 rs11548001	226	K>Q		No	ClinGen ExAC gnomAD
CA411607313 rs1181235764	231	V>A		No	ClinGen TOPMed
CA411607280 rs1175517198	236	H>Y		No	ClinGen gnomAD
rs1601627945 CA411607274	237	T>P		No	ClinGen Ensembl
CA324381872 rs11547998	241	P>A		No	ClinGen Ensembl
CA411607244 rs1479322742	241	P>L		No	ClinGen gnomAD
CA10240662 rs775459765	242	R>C		No	ClinGen ExAC gnomAD
rs1480072027 CA411607241	242	R>H		No	ClinGen gnomAD
CA324381868 rs11547997	244	T>N		No	ClinGen Ensembl
CA324381863 rs11548005	247	G>A		No	ClinGen Ensembl
CA411607199 rs1222108973	249	R>H	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs11547974 CA324381839	252	A>V		No	ClinGen Ensembl
rs371621495 CA324381835	254	I>V		No	ClinGen ESP TOPMed
TCGA novel	259	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411607120 rs1391052316	261	R>C		No	ClinGen gnomAD
rs756974808 CA10240658	261	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs565234105 CA10240657	262	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs1401008318 CA411607102	264	F>S		No	ClinGen gnomAD
CA10240654 rs752027363	269	A>G		No	ClinGen ExAC gnomAD
rs376713053 CA324381820	269	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed
rs758690938 CA10240652	270	G>A		No	ClinGen ExAC gnomAD
rs765682661 CA10240650	272	K>E		No	ClinGen ExAC gnomAD
CA411607043 rs1202352615	274	Y>H		No	ClinGen gnomAD
rs373710970 CA10240648	277	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10240647 rs373678761	277	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10240645 rs550820949	278	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA10240644 rs771979459	279	E>D		No	ClinGen ExAC gnomAD
CA411607007 rs1241019174	279	E>G		No	ClinGen gnomAD
rs575413950 CA10240642	280	I>F		No	ClinGen 1000Genomes ExAC gnomAD
CA10240641 rs770692974	280	I>N		No	ClinGen ExAC gnomAD
rs575413950 CA10240643	280	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA10240640 rs375753135	281	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA10240638 rs769199053	282	K>N		No	ClinGen ExAC gnomAD
rs777352920 CA10240639	282	K>R		No	ClinGen ExAC gnomAD
CA324381274 rs961965304	285	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs754189403 CA10240611	287	I>T		No	ClinGen ExAC
TCGA novel	289	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411606912 rs1388112815	291	Y>*		No	ClinGen gnomAD
rs1321144068 CA411606918	291	Y>H		No	ClinGen gnomAD
rs777996527 CA10240610	293	I>V		No	ClinGen ExAC gnomAD
rs752844997 CA10240608	294	K>R		No	ClinGen ExAC gnomAD
CA10240609 rs752844997	294	K>T		No	ClinGen ExAC gnomAD
rs759576258 CA10240606	296	G>S		No	ClinGen ExAC TOPMed gnomAD
CA411606843 rs1452343384	302	N>D		No	ClinGen gnomAD
rs571917302 CA10240604	302	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs528795057 CA10240603	303	A>V		No	ClinGen 1000Genomes ExAC gnomAD
rs561225571 CA10240601	304	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	306	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411606809 rs1272811845	307	Y>C		No	ClinGen gnomAD
rs17850346 CA324381223	310	S>P		No	ClinGen Ensembl
CA10240597 rs530517227	312	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA10240594 rs376187880	315	N>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA10240591 rs748437734	316	P>L		No	ClinGen ExAC TOPMed gnomAD
CA10240592 rs756404924	316	P>S		No	ClinGen ExAC gnomAD
rs1176380379 CA411606091	319	G>S		No	ClinGen gnomAD
CA411606076 rs1438625276	320	F>I		No	ClinGen gnomAD
rs757907162 CA10240499	322	H>Q		No	ClinGen ExAC gnomAD
rs767797371 CA324380739	322	H>R		No	ClinGen Ensembl
CA411606045 rs1164148859	322	H>Y		No	ClinGen TOPMed
CA10240497 rs750001891	323	Y>C		No	ClinGen ExAC gnomAD
CA411605989 rs1256032033	326	V>M		No	ClinGen gnomAD
rs930612882 CA324380709	328	N>S		No	ClinGen gnomAD
TCGA novel	329	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411605920 rs753173066	330	F>C		No	ClinGen ExAC TOPMed gnomAD
CA10240494 rs753173066	330	F>S		No	ClinGen ExAC TOPMed gnomAD
CA411605888 rs1323130505	332	M>T		No	ClinGen TOPMed
rs1351706566 CA411605895	332	M>V		No	ClinGen gnomAD
rs759898086 CA10240492	334	K>E		No	ClinGen ExAC gnomAD
rs1311887699 CA411605820	336	C>R		No	ClinGen gnomAD
rs541265834 CA411605744	340	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs541265834 CA10240490	340	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1381083772 CA411605753	340	T>P		No	ClinGen gnomAD
rs541265834 CA10240489	340	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA411605724 rs1418774585	341	K>E		No	ClinGen gnomAD
CA10240487 rs769959563	347	L>F		No	ClinGen ExAC TOPMed gnomAD
CA324380647 rs375229574	348	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs375229574 CA411605593	348	R>S		No	ClinGen ESP TOPMed gnomAD
rs961631807 CA324380232	352	L>M		No	ClinGen TOPMed gnomAD
rs758783912 CA411605390	352	L>P		No	ClinGen ExAC TOPMed gnomAD
rs758783912 CA10240450	352	L>R		No	ClinGen ExAC TOPMed gnomAD
rs765487298 CA411605360	354	Q>P		No	ClinGen ExAC gnomAD
CA10240448 rs765487298	354	Q>R		No	ClinGen ExAC gnomAD
CA10240447 rs761936196	355	T>M		No	ClinGen ExAC TOPMed gnomAD
CA10240445 rs764058582	357	R>Q		No	ClinGen ExAC gnomAD
rs1473561547 CA411605313	357	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10240443 rs771878324	358	R>P		No	ClinGen ExAC TOPMed gnomAD
CA10240442 rs771878324	358	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA411605296 rs760707879	358	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	365	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411605251 rs1456340727	365	L>V		No	ClinGen gnomAD
CA324380197 rs994526705	368	I>T		No	ClinGen Ensembl
rs150061768 COSM1535493 CA10240440	368	I>V	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC
rs1352679078 CA411605196	373	K>T		No	ClinGen TOPMed
TCGA novel	374	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10240436 rs139501357	378	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139501357 CA411605162	378	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs747570922 CA10240435	378	R>H		No	ClinGen ExAC gnomAD
rs780647143 CA10240434	380	Q>H		No	ClinGen ExAC gnomAD
rs758836953 CA10240433	382	M>I		No	ClinGen ExAC TOPMed gnomAD
rs2014840 CA324379775	390	G>V		No	ClinGen Ensembl
rs17856252 CA324379763	394	K>E		No	ClinGen Ensembl
rs145936719 CA324379761	395	D>H		No	ClinGen ESP
rs769973448 CA10240388	396	R>Q		No	ClinGen ExAC gnomAD
CA411605011 rs1292616714	398	A>G		No	ClinGen gnomAD
rs141236265 CA10240387	398	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1292616714 CA411605010	398	A>V		No	ClinGen gnomAD
TCGA novel	400	E>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781293920 CA10240386	401	E>G		No	ClinGen ExAC gnomAD
CA10240385 rs755015177	402	G>E		No	ClinGen ExAC gnomAD
CA411604981 rs1276622874	403	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1298802338 CA411604976	403	A>V		No	ClinGen gnomAD

No associated diseases with P39023

1 regional properties for P39023

Type	Name	Position	InterPro Accession
conserved_site	Ribosomal protein L22/L17, conserved site	126 - 150	IPR018260

Functions

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
cytosolic large ribosomal subunit	The large subunit of a ribosome located in the cytosol.
cytosolic ribosome	A ribosome located in the cytosol.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

3 GO annotations of molecular function

Name	Definition
5S rRNA binding	Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome.
RNA binding	Binding to an RNA molecule or a portion thereof.
structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.

3 GO annotations of biological process

Name	Definition
cellular response to interleukin-4	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.
cytoplasmic translation	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.

3 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q92901	RPL3L	60S ribosomal protein L3-like	Homo sapiens (Human)	PR
P27659	Rpl3	60S ribosomal protein L3	Mus musculus (Mouse)	PR
P21531	Rpl3	60S ribosomal protein L3	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MSHRKFSAPR	HGSLGFLPRK	RSSRHRGKVK	SFPKDDPSKP	VHLTAFLGYK	AGMTHIVREV
70	80	90	100	110	120
DRPGSKVNKK	EVVEAVTIVE	TPPMVVVGIV	GYVETPRGLR	TFKTVFAEHI	SDECKRRFYK
130	140	150	160	170	180
NWHKSKKKAF	TKYCKKWQDE	DGKKQLEKDF	SSMKKYCQVI	RVIAHTQMRL	LPLRQKKAHL
190	200	210	220	230	240
MEIQVNGGTV	AEKLDWARER	LEQQVPVNQV	FGQDEMIDVI	GVTKGKGYKG	VTSRWHTKKL
250	260	270	280	290	300
PRKTHRGLRK	VACIGAWHPA	RVAFSVARAG	QKGYHHRTEI	NKKIYKIGQG	YLIKDGKLIK
310	320	330	340	350	360
NNASTDYDLS	DKSINPLGGF	VHYGEVTNDF	VMLKGCVVGT	KKRVLTLRKS	LLVQTKRRAL
370	380	390	400
EKIDLKFIDT	TSKFGHGRFQ	TMEEKKAFMG	PLKKDRIAKE	EGA