P27659
PR
Gene name |
Rpl3 |
Protein name |
60S ribosomal protein L3 |
Names |
J1 protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:27367 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
20 variants for P27659
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389325549 | 18 | P>L | No | EVA | |
| rs3389365460 | 40 | P>T | No | EVA | |
| rs3389384091 | 78 | I>N | No | EVA | |
| rs3404760707 | 79 | V>G | No | EVA | |
| rs3404760762 | 80 | E>G | No | EVA | |
| rs3406345441 | 81 | T>A | No | EVA | |
| rs3406345481 | 81 | T>I | No | EVA | |
| rs3406300359 | 82 | P>S | No | EVA | |
| rs3405788364 | 83 | P>T | No | EVA | |
| rs46238075 | 151 | N>S | No | EVA | |
| rs47864525 | 174 | R>H | No | EVA | |
| rs3389368463 | 236 | H>L | No | EVA | |
| rs46950095 | 246 | R>* | No | EVA | |
| rs3389390114 | 316 | P>S | No | EVA | |
| rs3389373153 | 321 | V>M | No | EVA | |
| rs3389354891 | 324 | G>D | No | EVA | |
| rs3389384134 | 325 | E>D | No | EVA | |
| rs3389365455 | 330 | F>S | No | EVA | |
| rs3389377317 | 352 | L>M | No | EVA | |
| rs3389373216 | 373 | K>* | No | EVA |
No associated diseases with P27659
1 regional properties for P27659
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Ribosomal protein L3, conserved site | 211 - 234 | IPR019926 |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| cytosolic large ribosomal subunit | The large subunit of a ribosome located in the cytosol. |
| cytosolic ribosome | A ribosome located in the cytosol. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| ribosome | An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5S rRNA binding | Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to interleukin-4 | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. |
| cytoplasmic translation | The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. |
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSHRKFSAPR | HGSLGFLPRK | RSSRHRGKVK | SFPKDDASKP | VHLTAFLGYK | AGMTHIVREV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DRPGSKVNKK | EVVEAVTIVE | TPPMVVVGIV | GYVETPRGLR | TFKTVFAEHI | SDECKRRFYK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NWHKSKKKAF | TKYCKKWQDD | TGKKQLEKDF | NSMKKYCQVI | RIIAHTQMRL | LPLRQKKAHL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MEIQVNGGTV | AEKLDWARER | LEQQVPVNQV | FGQDEMIDVI | GVTKGKGYKG | VTSRWHTKKL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PRKTHRGLRK | VACIGAWHPA | RVAFSVARAG | QKGYHHRTEI | NKKIYKIGQG | YLIKDGKLIK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NNASTDYDLS | DKSINPLGGF | VHYGEVTNDF | IMLKGCVVGT | KKRVLTLRKS | LLVQTKRRAL |
| 370 | 380 | 390 | 400 | ||
| EKIDLKFIDT | TSKFGHGRFQ | TMEEKKAFMG | PLKKDRIAKE | EGA |