P39006
Gene name |
PSD1 |
Protein name |
Phosphatidylserine decarboxylase proenzyme 1, mitochondrial |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YNL169C |
EC number |
4.1.1.65: Carboxy-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P39006
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P39006-F1 | Predicted | AlphaFoldDB |
3 variants for P39006
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s14-316844 | 277 | G>D | No | SGRP | |
| s14-316784 | 297 | R>Q | No | SGRP | |
| s14-316710 | 322 | F>V | No | SGRP |
No associated diseases with P39006
No regional properties for P39006
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P39006 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 4.1.1.65 | Carboxy-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of mitochondrial inner membrane | The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| phosphatidylserine decarboxylase activity | Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial electron transport, ubiquinol to cytochrome c | The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. |
| phosphatidylcholine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
| phosphatidylethanolamine biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
| positive regulation of mitochondrial fusion | Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. |
| positive regulation of protein processing | Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage. |
| protein autoprocessing | Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. |
| response to pH | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q10T43 | PSD1 | Phosphatidylserine decarboxylase proenzyme 1, mitochondrial | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSIMPVKNAL | AQGRTLLMGR | MPAVKFSTRM | QLRNRTAVLW | NRKFSTRLFV | QQRRSSGEIV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DRAKAAAANS | GRKQVSMKWV | VLTSFTIVLG | TILLVSRNDS | TEEDATEGKK | GRRTRKIKIF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NNNWLFFCYS | TLPLNAMSRL | WGQVNSLTLP | IWVRPWGYRL | YSFLFGVNLD | EMEDPDLTHY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ANLSEFFYRN | IKPGTRPVAQ | GEDVIASPSD | GKILQVGIIN | SETGEIEQVK | GMTYSIKEFL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GTHSHPLMSK | SASSLDLTSD | EEKHREFARV | NRIQLAGSED | TEQPLLNFKN | EGDQSVREFK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSVSKNIHLL | SQLSLNYFSN | GFSCSEPHDT | ELFFAVIYLA | PGDYHHFHSP | VDWVCKVRRH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPGDLFSVAP | YFQRNFPNLF | VLNERVALLG | SWKYGFFSMT | PVGATNVGSI | KLNFDQEFVT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NSKSDKHLEP | HTCYQAVYEN | ASKILGGMPL | VKGEEMGGFE | LGSTVVLCFE | APTEFKFDVR |
| 490 | |||||
| VGDKVKMGQK | LGIIGKNDLK |