P38961
Gene name |
RRP8 (YDR083W, D4461) |
Protein name |
25S rRNA (adenine(645)-N(1))-methyltransferase |
Names |
Ribosomal RNA-processing protein 8 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDR083W |
EC number |
2.1.1.287: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38961
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38961-F1 | Predicted | AlphaFoldDB |
7 variants for P38961
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-612082 | 5 | N>D | No | SGRP | |
| s04-612168 | 33 | N>K | No | SGRP | |
| s04-612250 | 61 | P>A | No | SGRP | |
| s04-612302 | 78 | S>N | No | SGRP | |
| s04-612320 | 84 | S>N | No | SGRP | |
| s04-612355 | 96 | M>L | No | SGRP | |
| s04-612394 | 109 | Q>K | No | SGRP |
No associated diseases with P38961
No regional properties for P38961
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P38961 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.287 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| 90S preribosome | A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| rRNA (adenine) methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. |
| rRNA (adenine-N1-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| ribosomal large subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. |
| rRNA methylation | The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O43159 | RRP8 | Ribosomal RNA-processing protein 8 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALFNVEGWS | IKTKTVAFDN | KTNKSSKDKK | KNNRKNGKLT | REQKLKEETE | AELKEQVEDI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSEGSVAKDI | PKKNQEKSDQ | NETSKKRKHD | EEAPLMQVKE | NIEKPTKKQL | TPLQQKMMAK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LTGSRFRWIN | EQLYTISSDE | ALKLIKEQPQ | LFDEYHDGFR | SQVQAWPENP | VDVFVDQIRY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RCMKPVNAPG | GLPGLKDSKE | IVIADMGCGE | AQLALEINNF | FKNYNKKAKK | YLKRRHKVHS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FDLKKANERI | TVADIRNVPL | PDESCTIVVF | CLALMGTNFL | DFIKEAYRIL | APRGELWIAE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IKSRFSDGKG | NEFVDALKLM | GFFHKKTFDE | NKMFTRFEFF | KPPAEIIEER | RQKLERRQKF |
| 370 | 380 | 390 | |||
| IEVETEKEEL | EKKRRKIAEG | KWLLKPCIYK | RR |