P38760
Gene name |
MIP6 (YHR015W) |
Protein name |
RNA-binding protein MIP6 |
Names |
MEX67-interacting protein 6 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHR015W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P38760
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5D77 | X-ray | 130 A | A | 313-388 | PDB |
| 5D78 | X-ray | 125 A | A | 313-387 | PDB |
| AF-P38760-F1 | Predicted | AlphaFoldDB |
19 variants for P38760
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-134667 | 41 | I>V | No | SGRP | |
| s08-134706 | 54 | Y>D | No | SGRP | |
| s08-134715 | 57 | G>S | No | SGRP | |
| s08-134719 | 58 | D>G | No | SGRP | |
| s08-134731 | 62 | K>R | No | SGRP | |
| s08-134772 | 76 | D>Y | No | SGRP | |
| s08-134875 | 110 | T>K | No | SGRP | |
| s08-135271 | 242 | V>A | No | SGRP | |
| s08-135381 | 279 | T>A | No | SGRP | |
| s08-135410 | 288 | K>N | No | SGRP | |
| s08-135741 | 399 | N>D | No | SGRP | |
| s08-135760 | 405 | Y>F | No | SGRP | |
| s08-135759 | 405 | Y>H | No | SGRP | |
| s08-135940 | 465 | R>K | No | SGRP | |
| s08-136060 | 505 | I>T | No | SGRP | |
| s08-136081 | 512 | R>P | No | SGRP | |
| s08-136083 | 513 | T>A | No | SGRP | |
| s08-136259 | 571 | Q>H | No | SGRP | |
| s08-136339 | 598 | S>N | No | SGRP |
No associated diseases with P38760
4 regional properties for P38760
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA recognition motif domain | 111 - 189 | IPR000504-1 |
| domain | RNA recognition motif domain | 199 - 270 | IPR000504-2 |
| domain | RNA recognition motif domain | 313 - 389 | IPR000504-3 |
| domain | RNA recognition motif domain | 403 - 476 | IPR000504-4 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| prospore membrane | The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA 3'-UTR binding | Binding to a 3' untranslated region of an mRNA molecule. |
| poly(A) binding | Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. |
| poly(U) RNA binding | Binding to a sequence of uracil residues in an RNA molecule. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA localization resulting in post-transcriptional regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell. |
| mRNA metabolic process | The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. |
| regulation of translation | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P49960 | PRP24 | U4/U6 snRNA-associated-splicing factor PRP24 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPNSHGNVLN | NISLNSKQNP | RSISKSCPND | KDARQKSFKT | ISAQALVRVQ | GAGYKLGDVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKDAEVKEKN | SLKKYDCKNA | TQEKKEQEQV | FEKTVAKGSV | QKYITKTSKT | NSLFIGNLKS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TVTEEMLRKI | FKRYQSFESA | KVCRDFLTKK | SLGYGYLNFK | DKNDAESARK | EFNYTVFFGQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVKIMPSMKN | TLFRKNIGTN | VFFSNLPLEN | PQLTTRSFYL | IMIEYGNVLS | CLLERRKNIG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FVYFDNDISA | RNVIKKYNNQ | EFFGNKIICG | LHFDKEVRTR | PEFTKRKKMI | GSDIVIEDEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LASNNLSDNA | RSKTILVKNL | PSDTTQEEVL | DYFSTIGPIK | SVFISEKQAN | TPHKAFVTYK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NEEESKKAQK | CLNKTIFKNH | TIWVGPGKDK | PVHNQIGTNK | KTKVYLKNLS | FNCNKEFISQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LCLQEKIRFS | EIKITNYNSL | NWTFCGHVEC | FSRSDAERLF | NILDRRLIGS | SLVEASWSKN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NDNILNEIDY | DDGNNNENYK | KLINISSMMR | FRTQELSAHQ | KGLTSQFQQV | VSPFSSYSNS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YTNMNSLVAT | PMKPHPAFNL | ITNTVDEKLH | QPKRTKQENA | EILESLKKII | NRNLQRISIS |
| 610 | 620 | 630 | 640 | 650 | |
| GLNKEENLRS | ISEFIFDVFW | EHDSERLSHF | LLMTNTSLES | QKILQKQVTR | AAESLGFTV |