P38755
PR
Gene name |
OSH7 (YHR001W) |
Protein name |
Oxysterol-binding protein homolog 7 |
Names |
Oxysterol-binding protein-related protein 7, ORP 7, OSBP-related protein 7 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YHR001W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P38755
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P38755-F1 | Predicted | AlphaFoldDB |
9 variants for P38755
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s08-106495 | 149 | F>Y | No | SGRP | |
| s08-106655 | 202 | F>L | No | SGRP | |
| s08-106845 | 266 | I>L | No | SGRP | |
| s08-106888 | 280 | Q>R | No | SGRP | |
| s08-106942 | 298 | S>N | No | SGRP | |
| s08-106953 | 302 | T>A | No | SGRP | |
| s08-107146 | 366 | A>D | No | SGRP | |
| s08-107184 | 379 | R>W | No | SGRP | |
| s08-107304 | 419 | T>A | No | SGRP |
No associated diseases with P38755
1 regional properties for P38755
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Oxysterol-binding protein, conserved site | 153 - 164 | IPR018494 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cortical endoplasmic reticulum | A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| lipid binding | Binding to a lipid. |
| phosphatidylinositol-4-phosphate binding | Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. |
| phosphatidylserine binding | Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. |
| phospholipid transporter activity | Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. |
| sterol binding | Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. |
| sterol transfer activity | Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. |
| sterol transporter activity | Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| late endosome to vacuole transport | The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. |
| maintenance of cell polarity | The maintenance of established anisotropic intracellular organization or cell growth patterns. |
| phospholipid transport | The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. |
| piecemeal microautophagy of the nucleus | Degradation of a cell nucleus by lysosomal microautophagy. |
| sterol metabolic process | The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
| sterol transport | The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P35843 | HES1 | Oxysterol-binding protein homolog 5 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P35844 | KES1 | Oxysterol-binding protein homolog 4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q9BZF1 | OSBPL8 | Oxysterol-binding protein-related protein 8 | Homo sapiens (Human) | PR |
| B9EJ86 | Osbpl8 | Oxysterol-binding protein-related protein 8 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALNKLKNIP | SLTNSSHSSI | NGIASNAANS | KPSGADTDDI | DENDESGQSI | LLNIISQLKP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GCDLSRITLP | TFILEKKSML | ERITNQLQFP | DVLLEAHSNK | DGLQRFVKVV | AWYLAGWHIG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PRAVKKPLNP | ILGEHFTAYW | DLPNKQQAFY | IAEQTSHHPP | ESAYFYMIPE | SNIRVDGVVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PKSKFLGNSS | AAMMEGLTVL | QFLDIKDANG | KPEKYTLSQP | NVYARGILFG | KMRIELGDHM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIMGPKYQVD | IEFKTKGFIS | GTYDAIEGTI | KDYDGKEYYQ | ISGKWNDIMY | IKDLREKSSK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KTVLFDTHQH | FPLAPKVRPL | EEQGEYESRR | LWKKVTDALA | VRDHEVATEE | KFQIENRQRE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LAKKRAEDGV | EFHSKLFRRA | EPGEDLDYYI | YKHIPEGTDK | HEEQIRSILE | TAPILPGQTF |
| 430 | |||||
| TEKFSIPAYK | KHGIQKN |