P38333

PR
Gene name
ENP1 (MEG1, YBR247C, YBR1635)
Protein name
Essential nuclear protein 1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR247C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-131 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

31 structures for P38333

Entry ID Method Resolution Chain Position Source
5WLC EM 380 A SZ 1-483 PDB
5WWO X-ray 240 A A/B 121-483 PDB
5WYJ EM 870 A E3 1-483 PDB
6EML EM 360 A e 1-483 PDB
6FAI EM 340 A i 1-483 PDB
6KE6 EM 340 A RS 1-483 PDB
6LQP EM 320 A RS 1-483 PDB
6LQQ EM 410 A RS 1-483 PDB
6LQR EM 860 A RS 1-483 PDB
6LQS EM 380 A RS 1-480 PDB
6LQU EM 370 A RS 1-483 PDB
6LQV EM 480 A RS 1-483 PDB
6RBD EM 347 A i 1-483 PDB
6Y7C EM 380 A i 1-483 PDB
6ZQA EM 440 A JH 1-483 PDB
6ZQB EM 390 A JH 1-483 PDB
6ZQC EM 380 A JH 1-483 PDB
6ZQD EM 380 A JH 1-483 PDB
6ZQE EM 710 A JH 1-483 PDB
6ZQF EM 490 A JH 1-483 PDB
6ZQG EM 350 A JH 1-483 PDB
7AJT EM 460 A JH 1-483 PDB
7AJU EM 380 A JH 1-483 PDB
7D4I EM 400 A RS 1-480 PDB
7D5S EM 460 A RS 1-483 PDB
7D63 EM 1230 A RS 1-480 PDB
7SUK EM 399 A SZ 205-465 PDB
8C00 EM 290 A e 1-483 PDB
8C01 EM 270 A e 1-483 PDB
8CBJ EM 380 A i 1-483 PDB
AF-P38333-F1 Predicted AlphaFoldDB

9 variants for P38333

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-714272 60 R>K No SGRP
s02-714251 67 K>R No SGRP
s02-714229 74 E>D No SGRP
s02-714125 109 A>G No SGRP
s02-714126 109 A>P No SGRP
s02-714089 121 G>D No SGRP
s02-713991 154 S>R No SGRP
s02-713053 466 R>S No SGRP
s02-713033 473 E>G No SGRP

No associated diseases with P38333

No regional properties for P38333

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P38333

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

1 GO annotations of molecular function

Name Definition
snoRNA binding Binding to a small nucleolar RNA.

4 GO annotations of biological process

Name Definition
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.
poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O54825 Bysl Bystin Mus musculus (Mouse) PR
10 20 30 40 50 60
MARASSTKAR KQRHDPLLKD LDAAQGTLKK INKKKLAQND AANHDAANEE DGYIDSKASR
70 80 90 100 110 120
KILQLAKEQQ DEIEGEELAE SERNKQFEAR FTTMSYDDED EDEDEDEEAF GEDISDFEPE
130 140 150 160 170 180
GDYKEEEEIV EIDEEDAAMF EQYFKKSDDF NSLSGSYNLA DKIMASIREK ESQVEDMQDD
190 200 210 220 230 240
EPLANEQNTS RGNISSGLKS GEGVALPEKV IKAYTTVGSI LKTWTHGKLP KLFKVIPSLR
250 260 270 280 290 300
NWQDVIYVTN PEEWSPHVVY EATKLFVSNL TAKESQKFIN LILLERFRDN IETSEDHSLN
310 320 330 340 350 360
YHIYRAVKKS LYKPSAFFKG FLFPLVETGC NVREATIAGS VLAKVSVPAL HSSAALSYLL
370 380 390 400 410 420
RLPFSPPTTV FIKILLDKKY ALPYQTVDDC VYYFMRFRIL DDGSNGEDAT RVLPVIWHKA
430 440 450 460 470 480
FLTFAQRYKN DITQDQRDFL LETVRQRGHK DIGPEIRREL LAGASREFVD PQEANDDLMI
DVN