P38319
Gene name |
TDP1 (YBR223C, YBR1520) |
Protein name |
Tyrosyl-DNA phosphodiesterase 1 |
Names |
Tyr-DNA phosphodiesterase 1 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBR223C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
18 variants for P38319
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-670272 | 7 | F>L | No | SGRP | |
| s02-670252 | 14 | R>K | No | SGRP | |
| s02-670145 | 50 | V>I | No | SGRP | |
| s02-670086 | 69 | E>D | No | SGRP | |
| s02-670078 | 72 | E>G | No | SGRP | |
| s02-670066 | 76 | T>M | No | SGRP | |
| s02-670064 | 77 | A>T | No | SGRP | |
| s02-670051 | 81 | V>A | No | SGRP | |
| s02-669998 | 99 | V>I | No | SGRP | |
| s02-669581 | 238 | I>L | No | SGRP | |
| s02-669400 | 298 | S>N | No | SGRP | |
| s02-669354 | 313 | I>M | No | SGRP | |
| s02-669262 | 344 | D>G | No | SGRP | |
| s02-669257 | 346 | A>T | No | SGRP | |
| s02-669229 | 355 | P>L | No | SGRP | |
| s02-668963 | 444 | A>T | No | SGRP | |
| s02-668825 | 490 | R>G | No | SGRP | |
| s02-668747 | 516 | H>N | No | SGRP |
No associated diseases with P38319
No regional properties for P38319
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P38319 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-tyrosyl-DNA phosphodiesterase activity | Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. |
| 5'-tyrosyl-DNA phosphodiesterase activity | Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA. |
| double-stranded DNA binding | Binding to double-stranded DNA. |
| exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. |
| single-stranded DNA binding | Binding to single-stranded DNA. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| double-strand break repair | The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. |
| single strand break repair | The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VQM4 | gkt | Probable tyrosyl-DNA phosphodiesterase | Drosophila melanogaster (Fruit fly) | PR |
| Q9NUW8 | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (Human) | PR |
| Q8BJ37 | Tdp1 | Tyrosyl-DNA phosphodiesterase 1 | Mus musculus (Mouse) | PR |
| Q8H1D9 | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSRETNFNGT | KRKRSDVAEK | VAQRWKSVRY | SAEMENMAPV | NSNNDSDDCV | IVSESKIIDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TNQEQDLSER | IETNDTAKGA | VFKLMKSDFY | EREDFMGEVE | DMITLKDIFG | TETLKRSILF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SFQYELDFLL | RQFHQNVENI | TIVGQKGTIM | PIEARAMDAT | LAVILKKVKL | IEITMPPFAS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HHTKLIINFY | DNGECKIFLP | SNNFTSMETN | LPQQVCWCSP | LLKIGKEGLP | VPFKRSLIEY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LNSYHLKDID | ELITKSVEEV | NFAPLSELEF | VYSTPSKFQS | SGLLSFYNKL | EKLSAGTSAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DTAKHYLCQT | SSIGTSLSRA | RDENLWTHLM | IPLFTGIMSP | PAKDTAGRKK | AEILPTNSLI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NEYSQRKIKP | YIIFPTEQEF | VTSPLKWSSS | GWFHFQYLQK | KSYYEMLRNK | FKVFYKQDPA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MVTRRRGTTP | AHSKFYMHCA | TNSAGPCDAS | QVFKELEWCL | YTSANLSQTA | WGTVSRKPRN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YEAGVLYHSR | RLANTRKVTC | RTFTRDRRGC | AGNPTHVAVP | FTLPVIPYDL | AEDECFCLAR |
| HEND |