P36517

PR
Gene name
MRPL4 (YLR439W, L9753.1)
Protein name
54S ribosomal protein L4, mitochondrial
Names
Mitochondrial large ribosomal subunit protein uL29m, YmL4
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR439W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P36517

Entry ID Method Resolution Chain Position Source
3J6B EM 320 A T 1-319 PDB
5MRC EM 325 A T 15-239 PDB
5MRE EM 375 A T 15-239 PDB
5MRF EM 497 A T 15-239 PDB
AF-P36517-F1 Predicted AlphaFoldDB

1 variants for P36517

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-1014989 168 E>K No SGRP

No associated diseases with P36517

No regional properties for P36517

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P36517

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9HD33 MRPL47 39S ribosomal protein L47, mitochondrial Homo sapiens (Human) PR
Q8K2Y7 Mrpl47 39S ribosomal protein L47, mitochondrial Mus musculus (Mouse) PR
10 20 30 40 50 60
MWKRSFHSQG GPLRARTKFT KPKPKQPVLP KDKIRPPTQL THHSNNLRIT EPIPPTTSNL
70 80 90 100 110 120
RCPDDHPLWQ FFSNKKFIRS ADDLPPSSHI RPWSIPELRH KSFNDLHSLW YNCLREQNVL
130 140 150 160 170 180
ARENHLLKNI VGSTHDEFSE LSNSIRTTMW QIRHVLNERE LAYSASREFL QDESERKKFL
190 200 210 220 230 240
DTLANDYFLN KDIPDDEVAS MLTRFQLAIF GISETIQDNT VDINFIDGIK FLANLKLQRF
250 260 270 280 290 300
KDSNDLISEI SQEPITDVGE SFILFTSDFE PHAVQEACVA IKDLRKSPDN KVPKLDELPT
310
VRKYLKQLIH ASSVEQATA