P36381

PR
Gene name
GJA8
Protein name
Gap junction alpha-8 protein
Names
Connexin-45.6, Cx45.6
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395846
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

327-396 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P36381

Entry ID Method Resolution Chain Position Source
AF-P36381-F1 Predicted AlphaFoldDB

No variants for P36381

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P36381

No associated diseases with P36381

4 regional properties for P36381

Type Name Position InterPro Accession
domain Connexin, N-terminal 3 - 230 IPR013092
conserved_site Connexin, conserved site 54 - 67 IPR017990-1
conserved_site Connexin, conserved site 185 - 201 IPR017990-2
domain Gap junction protein, cysteine-rich domain 163 - 229 IPR019570

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Cell junction, gap junction
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
connexin complex An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
gap junction channel activity A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.

2 GO annotations of biological process

Name Definition
cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
gap junction-mediated intercellular transport The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P28236 Gja8 Gap junction alpha-8 protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MGDWSFLGNI LEQVNEQSTV IGRVWLTVLF IFRILILGTA AELVWGDEQS DFVCNTQQPG
70 80 90 100 110 120
CENVCYDEAF PISHIRLWVL QIIFVSTPSL VYFGHAVHHV RMEEKRKERE EAERRQQAEV
130 140 150 160 170 180
DEEKLPLAPN QNKGNNPDGT KKFRLEGTLL RTYILHIIFK TLFEVGFIVG QYFLYGFRIL
190 200 210 220 230 240
PLYRCGRWPC PNLVDCFVSR PTEKTIFIMF MLVVAAVSLF LNLVEISHLI LKRIRRALRR
250 260 270 280 290 300
PAEEQMGEVP EKPLHAIAVS SIPKAKGYKL LEEEKPVSHY FPLTEVGVEP SPLPSAFNEF
310 320 330 340 350 360
EEKIGMGPLE DLSRAFDERL PSYAQAKEPE EEKVKAEEEE EQEEEQQAPQ EEPGVKKAEE
370 380 390
EVVSDEVEGP SAPAELATDV RSLSRLSKAS SRARSDDLTV