P35525
PR
Gene name |
Clcn2 |
Protein name |
Chloride channel protein 2 |
Names |
ClC-2 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:29232 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P35525
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P35525-F1 | Predicted | AlphaFoldDB |
1 variants for P35525
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8166170 | 659 | R>M | No | EVA |
No associated diseases with P35525
No regional properties for P35525
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P35525 | |||
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| chloride channel complex | An ion channel complex through which chloride ions pass. |
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| perikaryon | The portion of the cell soma (neuronal cell body) that excludes the nucleus. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| voltage-gated chloride channel activity | Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| acinar cell differentiation | The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini. |
| cell differentiation involved in salivary gland development | The process in which a relatively unspecialized cell acquires specialized structural and/or functional features that characterize the cells of the salivary gland. |
| chloride transmembrane transport | The process in which chloride is transported across a membrane. |
| chloride transport | The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| lung development | The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. |
| regulation of aldosterone biosynthetic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. |
| regulation of ion transmembrane transport | Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other. |
| retina development in camera-type eye | The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P35523 | CLCN1 | Chloride channel protein 1 | Homo sapiens (Human) | PR |
| P51788 | CLCN2 | Chloride channel protein 2 | Homo sapiens (Human) | PR |
| Q64347 | Clcn1 | Chloride channel protein 1 | Mus musculus (Mouse) | PR |
| Q9R0A1 | Clcn2 | Chloride channel protein 2 | Mus musculus (Mouse) | PR |
| P35525 | Clcn2 | Chloride channel protein 2 | Rattus norvegicus (Rat) | PR |
| P35524 | Clcn1 | Chloride channel protein 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAATAAAAT | VAGEGMEPRA | LQYEQTLMYG | RYTQELGAFA | KEEAARIRLG | GPEPWKGSPS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ARATPELLEY | GQSRCARCRI | CSVRCHKFLV | SRVGEDWIFL | VLLGLLMALV | SWAMDYAIAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CLQAQQWMSR | GLNTNILLQY | LAWVTYPVVL | ITFSAGFTQI | LAPQAVGSGI | PEMKTILRGV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VLKEYLTLKT | FVAKVIGLTC | ALGSGMPLGK | EGPFVHIASM | CAALLSKFLS | LFGGIYENES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RNTEMLAAAC | AVGVGCCFAA | PIGGVLFSIE | VTSTFFAVRN | YWRGFFAATF | SAFIFRVLAV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WNRDEETITA | LFKTRFRLDF | PFDLQELPAF | AVIGIASGFG | GALFVYLNRK | IVQVMRKQKT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| INRFLMKKRL | LFPALVTLLI | STLTFPPGFG | QFMAGQLSQK | ETLVTLFDNR | TWVRQGLVED |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LGAPSTSQAW | SPPRANVFLT | LVIFILMKFW | MSALATTIPV | PCGAFMPVFV | IGAAFGRLVG |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ESMAAWFPDG | IHTDSSTYRI | VPGGYAVVGA | AALAGAVTHT | VSTAVIVFEL | TGQIAHILPV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MIAVILANAV | AQSLQPSLYD | SIIRIKKLPY | LPELGWGRHQ | QYRVRVEDIM | VRDVPHVALS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| CTFRDLRLAL | HRTKGRMLAL | VESPESMILL | GSIERSQVVA | LLGAQLSPAR | RRQHMQKLRK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AQMSPPSDQE | SPPSSETSIR | FQVNTEDSGF | PGAHGQTHKP | LKPALKRGPS | NATSLQEGTT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GNMESAGIAL | RSLFCGSPPL | ESTTSELEKS | ESCDKRKLKR | VRISLASDSD | LEGKMSPEEI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| LEWEEQQLDE | PVNFSDCKID | PAPFQLVERT | SLHKTHTIFS | LLGVDHAYVT | SIGRLIGIVT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LKELRKAIEG | SVTAQGVKVR | PPLASFRDSA | TSSSDTETTE | VHALWGPRSR | HGLPREGTPS |
| DSDDKCQ |