P35487

PR
Gene name
Pdha2 (Pdha-2, Pdhal)
Protein name
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Names
PDHE1-A type II
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18598
EC number
1.2.4.1: With a disulfide as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

266-337 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P35487

Entry ID Method Resolution Chain Position Source
AF-P35487-F1 Predicted AlphaFoldDB

19 variants for P35487

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388666695 23 R>K No EVA
rs3388663951 58 T>I No EVA
rs3388671358 74 R>G No EVA
rs3388668034 93 H>L No EVA
rs3388655490 115 V>L No EVA
rs3388647960 172 V>L No EVA
rs37097623 234 N>K No EVA
rs3388664395 237 S>L No EVA
rs1132388827 239 A>S No EVA
rs1133284564 240 S>I No EVA
rs1134573315 241 T>S No EVA
rs3388667098 266 A>V No EVA
rs3388667940 313 S>C No EVA
rs3388655915 320 L>M No EVA
rs3388647925 325 I>F No EVA
rs3388660354 333 I>N No EVA
rs3388662143 351 A>S No EVA
rs3388666740 353 F>C No EVA
rs3388666722 361 A>T No EVA

No associated diseases with P35487

1 regional properties for P35487

Type Name Position InterPro Accession
domain Dehydrogenase, E1 component 68 - 362 IPR001017

Functions

Description
EC Number 1.2.4.1 With a disulfide as acceptor
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).

2 GO annotations of molecular function

Name Definition
pyruvate dehydrogenase (acetyl-transferring) activity Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2.
pyruvate dehydrogenase (NAD+) activity Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH.

5 GO annotations of biological process

Name Definition
acetyl-CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
mitochondrial acetyl-CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA.
pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q06437 Pdha2 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MRKMLTAVLS HVFSGMVQKP ALRGLLSSLK FSNDATCDIK KCDLYRLEEG PPTSTVLTRA
70 80 90 100 110 120
EALKYYRTMQ VIRRMELKAD QLYKQKFIRG FCHLCDGQEA CCVGLEAGIN PTDHVITSYR
130 140 150 160 170 180
AHGFCYTRGL SVKSILAELT GRKGGCAKGK GGSMHMYGKN FYGGNGIVGA QVPLGAGVAF
190 200 210 220 230 240
ACKYLKNGQV CLALYGDGAA NQGQVFEAYN MSALWKLPCV FICENNLYGM GTSNERSAAS
250 260 270 280 290 300
TDYHKKGFII PGLRVNGMDI LCVREATKFA ADHCRSGKGP IVMELQTYRY HGHSMSDPGI
310 320 330 340 350 360
SYRSREEVHN VRSKSDPIML LRERIISNNL SNIEELKEID ADVKKEVEDA AQFATTDPEP
370 380 390
AVEDIANYLY HQDPPFEVRG AHKWLKYKSH S