P35194
PR
Gene name |
UTP20 (YBL004W, YBL0101) |
Protein name |
U3 small nucleolar RNA-associated protein 20 |
Names |
U3 snoRNA-associated protein 20, U three protein 20 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBL004W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
19 structures for P35194
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6KE6 | EM | 340 A | RP | 1-2493 | PDB |
| 6LQP | EM | 320 A | RP | 1-2493 | PDB |
| 6LQQ | EM | 410 A | RP | 1-2493 | PDB |
| 6LQR | EM | 860 A | RP | 1-2493 | PDB |
| 6LQS | EM | 380 A | RP | 1-2493 | PDB |
| 6LQT | EM | 490 A | RP | 1-2493 | PDB |
| 6LQU | EM | 370 A | RP | 1-2493 | PDB |
| 6LQV | EM | 480 A | RP | 1-2493 | PDB |
| 6ZQB | EM | 390 A | UT | 1-2493 | PDB |
| 6ZQC | EM | 380 A | UT | 1-2493 | PDB |
| 6ZQD | EM | 380 A | UT | 1-2493 | PDB |
| 6ZQE | EM | 710 A | UT | 1-2493 | PDB |
| 7AJT | EM | 460 A | UT | 1-2493 | PDB |
| 7AJU | EM | 380 A | UT | 1-2493 | PDB |
| 7D4I | EM | 400 A | RP | 1-2493 | PDB |
| 7D5T | EM | 600 A | RP | 1-2493 | PDB |
| 7D63 | EM | 1230 A | RP | 1-2493 | PDB |
| 7SUK | EM | 399 A | SP | 4-2421 | PDB |
| AF-P35194-F1 | Predicted | AlphaFoldDB |
48 variants for P35194
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-227808 | 57 | I>T | No | SGRP | |
| s02-228254 | 206 | S>P | No | SGRP | |
| s02-228443 | 269 | E>K | No | SGRP | |
| s02-228554 | 306 | L>F | No | SGRP | |
| s02-228584 | 316 | K>E | No | SGRP | |
| s02-228646 | 336 | I>M | No | SGRP | |
| s02-228648 | 337 | T>I | No | SGRP | |
| s02-228680 | 348 | E>K | No | SGRP | |
| s02-228997 | 453 | F>L | No | SGRP | |
| s02-229023 | 462 | R>K | No | SGRP | |
| s02-229158 | 507 | T>I | No | SGRP | |
| s02-229236 | 533 | S>L | No | SGRP | |
| s02-229337 | 567 | P>S | No | SGRP | |
| s02-229406 | 590 | M>V | No | SGRP | |
| s02-229443 | 602 | E>V | No | SGRP | |
| s02-229718 | 694 | A>T | No | SGRP | |
| s02-229755 | 706 | L>R | No | SGRP | |
| s02-229917 | 760 | T>I | No | SGRP | |
| s02-229940 | 768 | T>P | No | SGRP | |
| s02-229971 | 778 | A>V | No | SGRP | |
| s02-229984 | 782 | M>I | No | SGRP | |
| s02-230040 | 801 | Y>F | No | SGRP | |
| s02-230060 | 808 | K>E | No | SGRP | |
| s02-230071 | 811 | E>D | No | SGRP | |
| s02-230114 | 826 | V>F | No | SGRP | |
| s02-230258 | 874 | L>F | No | SGRP | |
| s02-230381 | 915 | A>P | No | SGRP | |
| s02-230579 | 981 | S>G | No | SGRP | |
| s02-230852 | 1072 | T>A | No | SGRP | |
| s02-231365 | 1243 | I>V | No | SGRP | |
| s02-231617 | 1327 | T>A | No | SGRP | |
| s02-231707 | 1357 | N>D | No | SGRP | |
| s02-231840 | 1401 | N>S | No | SGRP | |
| s02-231896 | 1420 | V>L | No | SGRP | |
| s02-231920 | 1428 | T>S | No | SGRP | |
| s02-232491 | 1618 | N>I | No | SGRP | |
| s02-232531 | 1631 | F>L | No | SGRP | |
| s02-232718 | 1694 | V>I | No | SGRP | |
| s02-234095 | 2153 | D>N | No | SGRP | |
| s02-234168 | 2177 | T>N | No | SGRP | |
| s02-234417 | 2260 | N>S | No | SGRP | |
| s02-234573 | 2312 | R>H | No | SGRP | |
| s02-234576 | 2313 | T>M | No | SGRP | |
| s02-234616 | 2326 | D>E | No | SGRP | |
| s02-234647 | 2337 | V>I | No | SGRP | |
| s02-234964 | 2442 | K>N | No | SGRP | |
| s02-235073 | 2479 | D>H | No | SGRP | |
| s02-235116 | 2493 | A>V | No | SGRP |
No associated diseases with P35194
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| 90S preribosome | A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| preribosome, small subunit precursor | A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. |
| small-subunit processome | A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. |
| endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. |
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O75691 | UTP20 | Small subunit processome component 20 homolog | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKQRQTTKS | SKRYRYSSFK | ARIDDLKIEP | ARNLEKRVHD | YVESSHFLAS | FDQWKEINLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AKFTEFAAEI | EHDVQTLPQI | LYHDKKIFNS | LVSFINFHDE | FSLQPLLDLL | AQFCHDLGPD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLKFYEEAIK | TLINLLDAAI | EFESSNVFEW | GFNCLAYIFK | YLSKFLVKKL | VLTCDLLIPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSHSKEYLSR | FSAEALSFLV | RKCPVSNLRE | FVRSVFEKLE | GDDEQTNLYE | GLLILFTESM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TSTQETLHSK | AKAIMSVLLH | EALTKSSPER | SVSLLSDIWM | NISKYASIES | LLPVYEVMYQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DFNDSLDATN | IDRILKVLTT | IVFSESGRKI | PDWNKITILI | ERIMSQSENC | ASLSQDKVAF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LFALFIRNSD | VKTLTLFHQK | LFNYALTNIS | DCFLEFFQFA | LRLSYERVFS | FNGLKFLQLF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LKKNWQSQGK | KIALFFLEVD | DKPELQKVRE | VNFPEEFILS | IRDFFVTAEI | NDSNDLFEIY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WRAIIFKYSK | LQNTEIIIPL | LERIFSTFAS | PDNFTKDMVG | TLLKIYRKED | DASGNNLLKT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ILDNYENYKE | SLNFLRGWNK | LVSNLHPSES | LKGLMSHYPS | LLLSLTDNFM | LPDGKIRYET |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LELMKTLMIL | QGMQVPDLLS | SCMVIEEIPL | TLQNARDLTI | RIKNVGAEFG | KTKTDKLVSS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FFLKYLFGLL | TVRFSPVWTG | VFDTLPNVYT | KDEALVWKLV | LSFIKLPDEN | QNLDYYQPLL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| EDGANKVLWD | SSVVRLRDTI | DTFSHIWSKY | STQNTSIIST | TIERRGNTTY | PILIRNQALK |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VMLSIPQVAE | NHFVDIAPFV | YNDFKTYKDE | EDMENERVIT | GSWTEVDRNV | FLKTLSKFKN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IKNVYSATEL | HDHLMVLLGS | RNTDVQKLAL | DALLAYKNPT | LNKYRDNLKN | LLDDTLFKDE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ITTFLTENGS | QSIKAEDEKV | VMPYVLRIFF | GRAQVPPTSG | QKRSRKIAVI | SVLPNFKKPY |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| INDFLSLASE | RLDYNYFFGN | SHQINSSKAT | LKTIRRMTGF | VNIVNSTLSV | LRTNFPLHTN |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SVLQPLIYSI | AMAYYVLDTE | STEEVHLRKM | ASNLRQQGLK | CLSSVFEFVG | NTFDWSTSME |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DIYAVVVKPR | ISHFSDENLQ | QPSSLLRLFL | YWAHNPSLYQ | FLYYDEFATA | TALMDTISNQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| HVKEAVIGPI | IEAADSIIRN | PVNDDHYVDL | VTLICTSCLK | ILPSLYVKLS | DSNSISTFLN |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LLVSITEMGF | IQDDHVRSRL | ISSLISILKG | KLKKLQENDT | QKILKILKLI | VFNYNCSWSD |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| IEELYTTISS | LFKTFDERNL | RVSLTELFIE | LGRKVPELES | ISKLVADLNS | YSSSRMHEYD |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| FPRILSTFKG | LIEDGYKSYS | ELEWLPLLFT | FLHFINNKEE | LALRTNASHA | IMKFIDFINE |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| KPNLNEASKS | ISMLKDILLP | NIRIGLRDSL | EEVQSEYVSV | LSYMVKNTKY | FTDFEDMAIL |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| LYNGDEEADF | FTNVNHIQLH | RRQRAIKRLG | EHAHQLKDNS | ISHYLIPMIE | HYVFSDDERY |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| RNIGNETQIA | IGGLAQHMSW | NQYKALLRRY | ISMLKTKPNQ | MKQAVQLIVQ | LSVPLRETLR |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| IVRDGAESKL | TLSKFPSNLD | EPSNFIKQEL | YPTLSKILGT | RDDETIIERM | PIAEALVNIV |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| LGLTNDDITN | FLPSILTNIC | QVLRSKSEEL | RDAVRVTLGK | ISIILGAEYL | VFVIKELMAT |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| LKRGSQIHVL | SYTVHYILKS | MHGVLKHSDL | DTSSSMIVKI | IMENIFGFAG | EEKDSENYHT |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| KVKEIKSNKS | YDAGEILASN | ISLTEFGTLL | SPVKALLMVR | INLRNQNKLS | ELLRRYLLGL |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| NHNSDSESES | ILKFCHQLFQ | ESEMSNSPQI | PKKKVKDQVD | EKEDFFLVNL | ESKSYTINSN |
| 1870 | 1880 | 1890 | 1900 | 1910 | 1920 |
| SLLLNSTLQK | FALDLLRNVI | TRHRSFLTVS | HLEGFIPFLR | DSLLSENEGV | VISTLRILIT |
| 1930 | 1940 | 1950 | 1960 | 1970 | 1980 |
| LIRLDFSDES | SEIFKNCARK | VLNIIKVSPS | TSSELCQMGL | KFLSAFIRHT | DSTLKDTALS |
| 1990 | 2000 | 2010 | 2020 | 2030 | 2040 |
| YVLGRVLPDL | NEPSRQGLAF | NFLKALVSKH | IMLPELYDIA | DTTREIMVTN | HSKEIRDVSR |
| 2050 | 2060 | 2070 | 2080 | 2090 | 2100 |
| SVYYQFLMEY | DQSKGRLEKQ | FKFMVDNLQY | PTESGRQSVM | ELINLIITKA | NPALLSKLSS |
| 2110 | 2120 | 2130 | 2140 | 2150 | 2160 |
| SFFLALVNVS | FNDDAPRCRE | MASVLISTML | PKLENKDLEI | VEKYIAAWLK | QVDNASFLNL |
| 2170 | 2180 | 2190 | 2200 | 2210 | 2220 |
| GLRTYKVYLK | SIGFEHTIEL | DELAIKRIRY | ILSDTSVGSE | HQWDLVYSAL | NTFSSYMEAT |
| 2230 | 2240 | 2250 | 2260 | 2270 | 2280 |
| ESVYKHGFKD | IWDGIITCLL | YPHSWVRQSA | ANLVHQLIAN | KDKLEISLTN | LEIQTIATRI |
| 2290 | 2300 | 2310 | 2320 | 2330 | 2340 |
| LHQLGAPSIP | ENLANVSIKT | LVNISILWKE | QRTPFIMDVS | KQTGEDLKYT | TAIDYMVTRI |
| 2350 | 2360 | 2370 | 2380 | 2390 | 2400 |
| GGIIRSDEHR | MDSFMSKKAC | IQLLALLVQV | LDEDEVIAEG | EKILLPLYGY | LETYYSRAVD |
| 2410 | 2420 | 2430 | 2440 | 2450 | 2460 |
| EEQEELRTLS | NECLKILEDK | LQVSDFTKIY | TAVKQTVLER | RKERRSKRAI | LAVNAPQISA |
| 2470 | 2480 | 2490 | |||
| DKKLRKHARS | REKRKHEKDE | NGYYQRRNKR | KRA |