P35172

PR
Gene name
NTH2 (YBR001C, YBR0106)
Protein name
Probable trehalase
Names
Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBR001C
EC number
3.2.1.28: Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-147 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P35172

Entry ID Method Resolution Chain Position Source
AF-P35172-F1 Predicted AlphaFoldDB

12 variants for P35172

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-241201 29 S>G No SGRP
s02-241198 30 G>S No SGRP
s02-240544 248 G>S No SGRP
s02-240441 282 E>G No SGRP
s02-240050 412 L>F No SGRP
s02-239953 445 S>P No SGRP
s02-239839 483 E>K No SGRP
s02-239628 553 G>E No SGRP
s02-239599 563 E>K No SGRP
s02-239530 586 Y>D No SGRP
s02-239436 617 K>I No SGRP
s02-239346 647 D>V No SGRP

No associated diseases with P35172

3 regional properties for P35172

Type Name Position InterPro Accession
domain Neutral trehalase Ca2+ binding 135 - 164 IPR011120
conserved_site Glycoside hydrolase, family 37, conserved site 328 - 341 IPR018232-1
conserved_site Glycoside hydrolase, family 37, conserved site 652 - 661 IPR018232-2

Functions

Description
EC Number 3.2.1.28 Glycosidases, ie enzymes hydrolyzing O- and S-glycosyl compounds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
alpha,alpha-trehalase activity Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose.
calcium ion binding Binding to a calcium ion (Ca2+).

1 GO annotations of biological process

Name Definition
trehalose catabolic process The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32356 NTH1 Cytosolic neutral trehalase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MVDFLPKVTE INPPSEGNDG EDNIKPLSSG SEQRPLKEEG QQGGRRHHRR LSSMHEYFDP
70 80 90 100 110 120
FSNAEVYYGP ITDPRKQSKI HRLNRTRTMS VFNKVSDFKN GMKDYTLKRR GSEDDSFLSS
130 140 150 160 170 180
QGNRRFYIDN VDLALDELLA SEDTDKNHQI TIEDTGPKVI KVGTANSNGF KHVNVRGTYM
190 200 210 220 230 240
LSNLLQELTI AKSFGRHQIF LDEARINENP VDRLSRLITT QFWTSLTRRV DLYNIAEIAR
250 260 270 280 290 300
DSKIDTPGAK NPRIYVPYNC PEQYEFYIQA SQMNPSLKLE VEYLPKDITA EYVKSLNDTP
310 320 330 340 350 360
GLLALAMEEH VNPSTGERSL VGYPYAVPGG RFNELYGWDS YLMALGLIES NKVDVARGMV
370 380 390 400 410 420
EHFIFEIDHY SKILNANRSY YLCRSQPPFL TDMALLVFEK IGGKNNPNAI QLLKRAFRAA
430 440 450 460 470 480
IKEYKEVWMS SPRLDSLTGL SCYHSDGIGI PPETEPDHFD TILLPYAEKY NVTLEKLRYL
490 500 510 520 530 540
YNEGMIKEPK LDAFFLHDRA VRESGHDTTY RFEGVCAYLA TIDLNSLLYK YEKDIAFVIK
550 560 570 580 590 600
EYFGNEYKDE NDGTVTDSEH WEELAELRKT RINKYMWDED SGFFFYYNTK LKCRTSYESA
610 620 630 640 650 660
TTFWSLWAGL ATEEQAKITV EKALPQLEML GGLVACTEKS RGPISIDRPI RQWDYPFGWA
670 680 690 700 710 720
PHQILAWKGL SAYGYQQVAT RLAYRWLYMI TKSFVDYNGM VVEKYDVTRG TDPHRVDAEY
730 740 750 760 770
GNQGADFKGV ATEGFGWVNT SYLLGLKYMN NHARRALAAC SPPLPFFNSL KPSEKKLYYL