P33893
Gene name |
PET112 |
Protein name |
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial |
Names |
Glu-AdT subunit B, Cytochrome c oxidase assembly factor PET112 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YBL080C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P33893
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4N0H | X-ray | 195 A | B | 16-329 | PDB |
| 4N0I | X-ray | 200 A | B | 16-329 | PDB |
| AF-P33893-F1 | Predicted | AlphaFoldDB |
15 variants for P33893
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s02-74685 | 3 | R>Q | No | SGRP | |
| s02-74515 | 60 | P>S | No | SGRP | |
| s02-74300 | 131 | K>N | No | SGRP | |
| s02-74260 | 145 | A>T | No | SGRP | |
| s02-73960 | 245 | P>S | No | SGRP | |
| s02-73755 | 313 | P>Q | No | SGRP | |
| s02-73697 | 332 | R>S | No | SGRP | |
| s02-73694 | 333 | I>M | No | SGRP | |
| s02-73638 | 352 | N>S | No | SGRP | |
| s02-73467 | 409 | K>R | No | SGRP | |
| s02-73449 | 415 | P>R | No | SGRP | |
| s02-73356 | 446 | N>S | No | SGRP | |
| s02-73351 | 448 | E>K | No | SGRP | |
| s02-73269 | 475 | V>A | No | SGRP | |
| s02-73270 | 475 | V>I | No | SGRP |
No associated diseases with P33893
3 regional properties for P33893
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| glutamyl-tRNA(Gln) amidotransferase complex | A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| glutaminyl-tRNAGln biosynthesis via transamidation | A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase. |
| mitochondrial translation | The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2R2Z0 | GATB | Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial | Oryza sativa subsp japonica (Rice) | PR |
| C5Y3V8 | GATB | Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial | Sorghum bicolor (Sorghum) (Sorghum vulgare) | PR |
| Q9FV81 | GATB | Glutamyl-tRNA(Gln) amidotransferase subunit B, chloroplastic/mitochondrial | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLRLARFYSL | ARTKAIHSHG | APFRPEYALK | CGLEIHTQLN | TKNKLFSQST | NSATSLVDAP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NHHTSYYDIA | LPGTQPVLNL | EAILFAMKLS | LALGSQVNSI | SQFDRKHYFY | GDQPQGYQLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QHYRPFARGG | KINLSKELDD | IDESAKEIGI | LQLQIEQDTG | KSHYTETDKD | VITLVDLNRS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVPLIELVTK | PDFSDIKQVR | AFIKKYQNLV | RHLHISSGDL | ETGAMRVDVN | LSINEYARVE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKNLPNTSSI | INAIKYEYQR | QVELISVGDT | SSLMEPETRG | WTGSSTVKLR | SKETTIDYRY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MPDPELPYIN | LAPDVISGVR | GLMPQLPDDI | MRILMKKPYQ | LSLKDAKILT | YNSNQNDMYN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HEALRSYYLD | TFREFSKLAG | ERSNAKLPTN | WIIHEFLGDL | NKLQIPLAKA | KEILPPPVFA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QFLKLLHEEV | ISATSGKMLL | FHILENFEQS | NCQDLSIPDF | SKLIEKFELH | AINQVDPQEL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MDLCNDVIAQ | HTDDTFIRNL | VTGKKKSSLK | FLIGQGMRRS | QGRIKANEFE | KKFKEILNIQ |
| W |