P33399
Gene name |
LHP1 (LAH1, YLA1, YDL051W) |
Protein name |
La protein homolog |
Names |
La autoantigen homolog, La ribonucleoprotein |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YDL051W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P33399
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P33399-F1 | Predicted | AlphaFoldDB |
3 variants for P33399
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s04-364690 | 247 | F>I | No | SGRP | |
| s04-364722 | 257 | E>D | No | SGRP | |
| s04-364735 | 262 | D>N | No | SGRP |
No associated diseases with P33399
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| small nuclear ribonucleoprotein complex | A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 7SK snRNA binding | Binding to a 7SK small nuclear RNA (7SK snRNA). |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tRNA binding | Binding to a transfer RNA. |
| U6 snRNA binding | Binding to a U6 small nuclear RNA (U6 snRNA). |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| box C/D RNA 3'-end processing | Any process involved in forming the mature 3' end of a box C/D RNA molecule. |
| regulation of mRNA splicing, via spliceosome | Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. |
| tRNA processing | The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q93ZV7 | LA1 | La protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEKPQQEEQ | EKPQSRRNSF | AVIEFTPEVL | DRCLKQVEFY | FSEFNFPYDR | FLRTTAEKND |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GWVPISTIAT | FNRMKKYRPV | DKVIEALRSS | EILEVSADGE | NVKRRVPLDL | TAARNARIEQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NQRTLAVMNF | PHEDVEASQI | PELQENLEAF | FKKLGEINQV | RLRRDHRNKK | FNGTVLVEFK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TIPECEAFLK | SYSNDDESNE | ILSYEGKKLS | VLTKKQFDLQ | REASKSKNFS | GRSRSFNGHK |
| 250 | 260 | 270 | |||
| KKNLPKFPKN | KKKNGKEESK | EDSSAIADDD | EEHKE |