P32838

PR
Gene name
PPG1 (PPG, YNR032W, N3281)
Protein name
Serine/threonine-protein phosphatase PP2A-like PPG1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YNR032W
EC number
3.1.3.16: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

272-354 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P32838

Entry ID Method Resolution Chain Position Source
AF-P32838-F1 Predicted AlphaFoldDB

1 variants for P32838

Variant ID(s) Position Change Description Diseaes Association Provenance
s14-686302 97 K>N No SGRP

No associated diseases with P32838

2 regional properties for P32838

Type Name Position InterPro Accession
domain Calcineurin-like phosphoesterase domain, ApaH type 44 - 248 IPR004843
domain Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 16 - 299 IPR006186

Functions

Description
EC Number 3.1.3.16 Phosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
FAR/SIN/STRIPAK complex A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate.
protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

2 GO annotations of biological process

Name Definition
asymmetric protein localization to old mitotic spindle pole body Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically.
glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23595 PPH22 Serine/threonine-protein phosphatase PP2A-2 catalytic subunit Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P23594 PPH21 Serine/threonine-protein phosphatase PP2A-1 catalytic subunit Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MELDECLERL YKAQLLPEVT VRALCFKLKE MLVKESNVIH IQTPVTVVGD MHGQFHDMLE
70 80 90 100 110 120
IFQIGGPVPD TNYLFLGDYV DRGLYSVETI MLLIVLKLRY PSRIHLLRGN HESRQITQSY
130 140 150 160 170 180
GFYTECLNKY GGNSRVWQYL TDIFDYLVLC CIIDDEIFCV HGGLSPNVQT IDQIKIIDRF
190 200 210 220 230 240
REIPHDGAMA DLVWSDPEEN NNPTLDHPDN SGQHFQVSPR GAGYTFGRSV VEKFLRMNDM
250 260 270 280 290 300
NRIYRAHQLC NEGYQIYFDG LVTTVWSAPN YCYRCGNKAS ILELYSKDQF YFNVFEEAPE
310 320 330 340 350 360
NKLLKENSMN DNALEDSISN PVANRKLIAD YFEDDSASAD GSTDPEMYIF SDVYQARSAS
NRHVDYFL