P32643

PR
Gene name
TMT1 (TAM1, YER175C, SYGP-ORF63)
Protein name
Trans-aconitate 3-methyltransferase
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YER175C
EC number
2.1.1.145: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P32643

Entry ID Method Resolution Chain Position Source
3G5T X-ray 112 A A 2-299 PDB
AF-P32643-F1 Predicted AlphaFoldDB

4 variants for P32643

Variant ID(s) Position Change Description Diseaes Association Provenance
s05-540268 31 E>K No SGRP
s05-540164 65 I>M No SGRP
s05-539650 237 V>M No SGRP
s05-539535 275 R>K No SGRP

No associated diseases with P32643

1 regional properties for P32643

Type Name Position InterPro Accession
domain Methyltransferase domain 25 41 - 143 IPR041698

Functions

Description
EC Number 2.1.1.145 Methyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

1 GO annotations of molecular function

Name Definition
trans-aconitate 3-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine.

1 GO annotations of biological process

Name Definition
methylation The process in which a methyl group is covalently attached to a molecule.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38892 CRG1 Probable S-adenosylmethionine-dependent methyltransferase CRG1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
10 20 30 40 50 60
MSTFSASDFN SERYSSSRPS YPSDFYKMID EYHDGERKLL VDVGCGPGTA TLQMAQELKP
70 80 90 100 110 120
FEQIIGSDLS ATMIKTAEVI KEGSPDTYKN VSFKISSSDD FKFLGADSVD KQKIDMITAV
130 140 150 160 170 180
ECAHWFDFEK FQRSAYANLR KDGTIAIWGY ADPIFPDYPE FDDLMIEVPY GKQGLGPYWE
190 200 210 220 230 240
QPGRSRLRNM LKDSHLDPEL FHDIQVSYFC AEDVRDKVKL HQHTKKPLLI RKQVTLVEFA
250 260 270 280 290
DYVRTWSAYH QWKQDPKNKD KEDVADWFIK ESLRRRPELS TNTKIEVVWN TFYKLGKRV