P32507
PR
Gene name |
Nectin2 |
Protein name |
Nectin-2 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:19294 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P32507
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4FMK | X-ray | 256 A | A | 32-250 | PDB |
| 4FN0 | X-ray | 335 A | A/B/C | 32-250 | PDB |
| 4FS0 | X-ray | 325 A | A | 32-250 | PDB |
| AF-P32507-F1 | Predicted | AlphaFoldDB |
19 variants for P32507
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388879850 | 2 | A>G | No | EVA | |
| rs3388860212 | 3 | R>L | No | EVA | |
| rs3388887113 | 32 | Q>E | No | EVA | |
| rs3388881775 | 70 | Q>L | No | EVA | |
| rs3388860213 | 75 | T>K | No | EVA | |
| rs3388866433 | 124 | E>* | No | EVA | |
| rs216178077 | 198 | T>I | No | EVA | |
| rs241241762 | 249 | R>L | No | EVA | |
| rs253587222 | 293 | V>I | No | EVA | |
| rs3388886658 | 326 | V>L | No | EVA | |
| rs580367542 | 367 | G>S | No | EVA | |
| rs3388885543 | 407 | E>D | No | EVA | |
| rs3388877118 | 415 | L>H | No | EVA | |
| rs3388873629 | 429 | P>A | No | EVA | |
| rs3388887791 | 429 | P>L | No | EVA | |
| rs3388866426 | 437 | C>S | No | EVA | |
| rs3388873633 | 437 | C>Y | No | EVA | |
| rs3388860188 | 493 | E>D | No | EVA | |
| rs3388877169 | 512 | S>G | No | EVA |
No associated diseases with P32507
8 regional properties for P32507
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Immunoglobulin subtype | 39 - 150 | IPR003599-1 |
| domain | Immunoglobulin subtype | 159 - 249 | IPR003599-2 |
| domain | Immunoglobulin subtype | 261 - 338 | IPR003599-3 |
| domain | Immunoglobulin-like domain | 14 - 131 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 153 - 247 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 252 - 337 | IPR007110-3 |
| domain | Immunoglobulin V-set domain | 41 - 149 | IPR013106 |
| domain | CD80-like, immunoglobulin C2-set | 158 - 239 | IPR013162 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical junction complex | A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. |
| cell surface | The external part of the cell wall and/or plasma membrane. |
| cell-cell contact zone | Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. |
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| zonula adherens | A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| cell adhesion molecule binding | Binding to a cell adhesion molecule. |
| identical protein binding | Binding to an identical protein or proteins. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
22 GO annotations of biological process
| Name | Definition |
|---|---|
| acrosome assembly | The formation of the acrosome from the spermatid Golgi. |
| adhesion of symbiont to host | The attachment of a symbiont to its host via either adhesion molecules, general stickiness, or other mechanisms. The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| cell part morphogenesis | The process in which the anatomical structures of a cell part are generated and organized. |
| cilium organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| coreceptor-mediated virion attachment to host cell | The process by which a virion attaches to a host cell by binding to a co-receptor on the host cell surface. |
| cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| establishment of mitochondrion localization | The directed movement of the mitochondrion to a specific location. |
| fertilization | The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). |
| fusion of virus membrane with host plasma membrane | Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm. |
| homophilic cell adhesion via plasma membrane adhesion molecules | The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. |
| positive regulation of immunoglobulin mediated immune response | Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response. |
| positive regulation of mast cell activation | Any process that activates or increases the frequency, rate, or extent of mast cell activation. |
| positive regulation of natural killer cell mediated cytotoxicity | Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity. |
| positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target. |
| positive regulation of T cell receptor signaling pathway | Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. |
| regulation of viral entry into host cell | Any process that modulates the frequency, rate or extent of the viral entry into the host cell. |
| sperm mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm. |
| spermatid development | The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. |
| spermatid nucleus differentiation | The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. |
| susceptibility to natural killer cell mediated cytotoxicity | The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity. |
| susceptibility to T cell mediated cytotoxicity | The process of causing a cell to become susceptible to T cell mediated cytotoxicity. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P15151 | PVR | Poliovirus receptor | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARAAVLPPS | RLSPTLPLLP | LLLLLLQETG | AQDVRVRVLP | EVRGRLGGTV | ELPCHLLPPT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TERVSQVTWQ | RLDGTVVAAF | HPSFGVDFPN | SQFSKDRLSF | VRARPETNAD | LRDATLAFRG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRVEDEGNYT | CEFATFPNGT | RRGVTWLRVI | AQPENHAEAQ | EVTIGPQSVA | VARCVSTGGR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PPARITWISS | LGGEAKDTQE | PGIQAGTVTI | ISRYSLVPVG | RADGVKVTCR | VEHESFEEPI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLPVTLSVRY | PPEVSISGYD | DNWYLGRSEA | ILTCDVRSNP | EPTDYDWSTT | SGVFPASAVA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QGSQLLVHSV | DRMVNTTFIC | TATNAVGTGR | AEQVILVRES | PSTAGAGATG | GIIGGIIAAI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IATAVAGTGI | LICRQQRKEQ | RLQAADEEEE | LEGPPSYKPP | TPKAKLEEPE | MPSQLFTLGA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SEHSPVKTPY | FDAGVSCADQ | EMPRYHELPT | LEERSGPLLL | GATGLGPSLL | VPPGPNVVEG |
| 490 | 500 | 510 | 520 | ||
| VSLSLEDEEE | DDEEEDFLDK | INPIYDALSY | PSPSDSYQSK | DFFVSRAMYV |