P15151

PR
Gene name
PVR (PVS)
Protein name
Poliovirus receptor
Names
Species
Homo sapiens (Human)
KEGG Pathway
hsa:5817
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

366-417 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

14 structures for P15151

Entry ID Method Resolution Chain Position Source
1DGI EM 2200 A R 28-329 PDB
1NN8 EM 1500 A R/S/T 28-329 PDB
3EPC EM 800 A R 30-242 PDB
3EPD EM 900 A R 30-242 PDB
3EPF EM 900 A R 30-242 PDB
3J8F EM 370 A 7 1-417 PDB
3J9F EM 900 A PDB
3UDW X-ray 290 A C/D 28-145 PDB
3URO X-ray 350 A R 29-243 PDB
4FQP X-ray 360 A A 28-334 PDB
6ARQ X-ray 288 A D 28-334 PDB
6ISC X-ray 220 A B 28-145 PDB
6O3O X-ray 280 A C/D 28-334 PDB
AF-P15151-F1 Predicted AlphaFoldDB

3 variants for P15151

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1058402
VAR_003952
 67 A>T No UniProt
dbSNP
VAR_049994
rs35365841
 295 A>T No UniProt
dbSNP
rs203710
VAR_011736
 340 I>M No UniProt
dbSNP

No associated diseases with P15151

7 regional properties for P15151

Type Name Position InterPro Accession
domain Immunoglobulin subtype 34 - 142 IPR003599-1
domain Immunoglobulin subtype 253 - 330 IPR003599-2
domain Immunoglobulin-like domain 24 - 123 IPR007110-1
domain Immunoglobulin-like domain 145 - 237 IPR007110-2
domain Immunoglobulin-like domain 244 - 328 IPR007110-3
domain Immunoglobulin V-set domain 33 - 142 IPR013106
domain CD80-like, immunoglobulin C2-set 148 - 231 IPR013162

Functions

Description
EC Number
Subcellular Localization
  • [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
cell surface The external part of the cell wall and/or plasma membrane.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
cell adhesion molecule binding Binding to a cell adhesion molecule.
signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
virus receptor activity Combining with a virus component and mediating entry of the virus into the cell.

6 GO annotations of biological process

Name Definition
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
homophilic cell adhesion via plasma membrane adhesion molecules The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
positive regulation of natural killer cell mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
susceptibility to natural killer cell mediated cytotoxicity The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.
susceptibility to T cell mediated cytotoxicity The process of causing a cell to become susceptible to T cell mediated cytotoxicity.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32507 Nectin2 Nectin-2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH
70 80 90 100 110 120
VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN
130 140 150 160 170 180
YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH
190 200 210 220 230 240
SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV
250 260 270 280 290 300
YYPPEVSISG YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR
310 320 330 340 350 360
PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRNAIIFLVL GILVFLILLG
370 380 390 400 410
IGIYFYWSKC SREVLWHCHL CPSSTEHASA SANGHVSYSA VSRENSSSQD PQTEGTR