P32031
Gene name |
slp2 (CG2939) |
Protein name |
Fork head domain transcription factor slp2 |
Names |
Sloppy paired locus protein 2 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG2939 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P32031
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P32031-F1 | Predicted | AlphaFoldDB |
No variants for P32031
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P32031 | |||||
No associated diseases with P32031
3 regional properties for P32031
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Heat shock protein 70, conserved site | 9 - 16 | IPR018181-1 |
| conserved_site | Heat shock protein 70, conserved site | 197 - 210 | IPR018181-2 |
| conserved_site | Heat shock protein 70, conserved site | 334 - 348 | IPR018181-3 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity | A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. |
| sequence-specific double-stranded DNA binding | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| segment polarity determination | Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O15353 | FOXN1 | Forkhead box protein N1 | Homo sapiens (Human) | PR |
| Q96NZ1 | FOXN4 | Forkhead box protein N4 | Homo sapiens (Human) | PR |
| Q08050 | FOXM1 | Forkhead box protein M1 | Homo sapiens (Human) | EV |
| Q12948 | FOXC1 | Forkhead box protein C1 | Homo sapiens (Human) | PR |
| Q8K3Q3 | Foxn4 | Forkhead box protein N4 | Mus musculus (Mouse) | PR |
| Q61572 | Foxc1 | Forkhead box protein C1 | Mus musculus (Mouse) | PR |
| O08696 | Foxm1 | Forkhead box protein M1 | Mus musculus (Mouse) | PR |
| P97691 | Foxm1 | Forkhead box protein M1 | Rattus norvegicus (Rat) | PR |
| Q28H65 | foxn5 | Forkhead box protein N5 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| A2BGM5 | foxn4 | Forkhead box protein N4 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVKIEEGLPS | SEISAHSLHF | QHHHHPLPPT | THHSALQSPH | PVGLNLTNLM | KMARTPHLKS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SFSINSILPE | TVEHHDEDEE | EDVEKKSPAK | FPPNHNNNNL | NTTNWGSPED | HEAESDPESD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDVTSMSPAP | VANPNESDPD | EVDEEFVEED | IECDGETTDG | DAENKSNDGK | PVKDKKGNEK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PPYSYNALIM | MAIRQSSEKR | LTLNGIYEYI | MTNHPYYRDN | KQGWQNSIRH | NLSLNKCFVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VPRHYDDPGK | GNYWMLDPSA | EDVFIGGSTG | KLRRRTTAAS | RSRLAAFKRS | LIGPMFPGLA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AYPQFGQFLT | YPPTAPSLLA | SMYQRYNPFA | PKGGPGHPGL | PPGLPGLPGP | PGPQGPPGPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PPPFVAPPTS | SELYQRLQYQ | QLLHQHAAAA | ALAAHQRQLS | VAAASAASQP | PPTHHHPHLA |
| 430 | 440 | 450 | |||
| VGQAPLSPGG | DSPGPSPQPL | HKPVTVVSRN | S |