AiPD: Autoinhibited Protein Database

P30419

Gene name	NMT1
Protein name	Glycylpeptide N-tetradecanoyltransferase 1
Names	Myristoyl-CoA:protein N-myristoyltransferase 1, HsNMT1, NMT 1, Type I N-myristoyltransferase, Peptide N-myristoyltransferase 1, Protein-lysine myristoyltransferase NMT1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4836
EC number	2.3.1.97: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

14-116 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

14-116 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

37 structures for P30419

Entry ID	Method	Resolution	Chain	Position	Source
1RXT	X-ray	300 A	A/B/C/D	1-496	PDB
3IU1	X-ray	142 A	A/B	115-496	PDB
3IU2	X-ray	173 A	A/B	115-496	PDB
3IWE	X-ray	179 A	A/B	115-496	PDB
3JTK	X-ray	161 A	A/B	115-496	PDB
4C2Y	X-ray	164 A	A/B	109-496	PDB
4C2Z	X-ray	208 A	A/B	109-496	PDB
5MU6	X-ray	188 A	A/B	109-496	PDB
5NPQ	X-ray	237 A	A/B	109-496	PDB
5O6H	X-ray	129 A	A/B	109-496	PDB
5O6J	X-ray	145 A	A/B	109-496	PDB
5O9S	X-ray	270 A	A/B	99-496	PDB
5O9T	X-ray	215 A	A/B	99-496	PDB
5O9U	X-ray	185 A	A/B	99-496	PDB
5O9V	X-ray	220 A	A/B	99-496	PDB
5UUT	X-ray	225 A	A/B	109-496	PDB
6EHJ	X-ray	210 A	A/B	109-496	PDB
6F56	X-ray	194 A	A/B/C/D	109-496	PDB
6FZ2	X-ray	205 A	A/B	115-496	PDB
6FZ3	X-ray	200 A	A/B	115-496	PDB
6FZ5	X-ray	189 A	A/B	115-496	PDB
6PAV	X-ray	252 A	A/B	109-496	PDB
6QRM	X-ray	230 A	A/B	99-496	PDB
6SJZ	X-ray	200 A	A/B	99-496	PDB
6SK2	X-ray	190 A	A/B	99-496	PDB
6SK3	X-ray	270 A	A/B	99-493	PDB
6SK8	X-ray	187 A	A/B	99-493	PDB
6SKJ	X-ray	280 A	A/B	99-494	PDB
7OWM	X-ray	150 A	A/B	99-496	PDB
7OWN	X-ray	210 A	A/B	99-496	PDB
7OWO	X-ray	170 A	A/B	99-496	PDB
7OWP	X-ray	181 A	A/B	99-496	PDB
7OWQ	X-ray	300 A	A/B	99-496	PDB
7OWR	X-ray	239 A	A/B	99-496	PDB
7OWU	X-ray	208 A	A/B	99-496	PDB
7RK3	X-ray	205 A	A	109-496	PDB
AF-P30419-F1	Predicted				AlphaFoldDB

286 variants for P30419

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA8610388 rs771527303	2	A>V		No	ClinGen ExAC gnomAD
rs1317068708 CA399828683	3	D>G		No	ClinGen Ensembl
rs772761859 CA8610389	3	D>H		No	ClinGen ExAC TOPMed gnomAD
rs760309598 CA8610390	4	E>G		No	ClinGen ExAC gnomAD
rs983223652 CA291007103	4	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA399828712 rs1314954450	5	S>N		No	ClinGen gnomAD
CA8610391 rs564172691	5	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA291007119 rs267604914	6	E>K		No	ClinGen Ensembl
CA291007135 rs1022554088	7	T>I		No	ClinGen TOPMed
rs1292079143 CA399828739	7	T>P		No	ClinGen gnomAD
rs907713546 CA291007140	8	A>P		No	ClinGen TOPMed gnomAD
rs907713546 CA399828754	8	A>T		No	ClinGen TOPMed gnomAD
rs764406772 CA8610394	8	A>V		No	ClinGen ExAC gnomAD
TCGA novel	9	V>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752105945 CA8610395	9	V>L		No	ClinGen ExAC gnomAD
CA399828795 rs767553043	11	P>A		No	ClinGen ExAC TOPMed gnomAD
rs750513385 CA8610398	11	P>L		No	ClinGen ExAC TOPMed gnomAD
CA291007153 rs767553043	11	P>S		No	ClinGen ExAC TOPMed gnomAD
CA8610397 rs767553043	11	P>T		No	ClinGen ExAC TOPMed gnomAD
CA8610399 rs756082410	12	P>L		No	ClinGen ExAC TOPMed gnomAD
CA399828807 rs756082410	12	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs973343235 CA291007180	13	A>E		No	ClinGen Ensembl
CA399828817 rs1424340537	13	A>P		No	ClinGen gnomAD
CA399828833 rs1356403688	14	P>L		No	ClinGen gnomAD
CA8610402 rs754859910	14	P>S		No	ClinGen ExAC TOPMed gnomAD
CA8610403 rs202061902	15	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1597997056 CA399828836	15	P>S		No	ClinGen Ensembl
rs772038652 CA8610405	16	L>R		No	ClinGen ExAC gnomAD
rs937347334 CA291007202	17	P>Q		No	ClinGen Ensembl
CA399828853 rs1567858504	17	P>S		No	ClinGen Ensembl
rs1597997099 CA399828874	18	Q>L		No	ClinGen Ensembl
CA399828887 rs1315229471	19	M>R		No	ClinGen gnomAD
CA399828886 rs1315229471	19	M>T		No	ClinGen gnomAD
CA8610406 rs772952636	20	M>R		No	ClinGen ExAC TOPMed gnomAD
rs1437942507 CA399828977	24	G>A		No	ClinGen gnomAD
CA8610407 rs746539074	24	G>R		No	ClinGen ExAC gnomAD
rs1451260585 CA399829001	26	G>D		No	ClinGen TOPMed
rs770300796 CA8610409	26	G>S		No	ClinGen ExAC gnomAD
rs776300314 CA8610410	27	H>Q		No	ClinGen ExAC gnomAD
CA399829015 rs1362841019	27	H>R		No	ClinGen TOPMed
CA399829020 rs1159616651	28	E>K		No	ClinGen TOPMed
CA399829027 rs1185809906 COSM1128678	28	E>V	prostate [Cosmic]	No	ClinGen cosmic curated gnomAD
rs759161485 CA8610411	29	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs764495116 CA8610412	30	C>Y		No	ClinGen ExAC gnomAD
rs774684452 CA8610413	31	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1597997161 CA399829087	32	D>G		No	ClinGen Ensembl
rs976121906 CA291007211	32	D>N		No	ClinGen TOPMed
rs895881728 CA291007214	33	C>S		No	ClinGen Ensembl
rs762294220 CA399829117	33	C>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	36	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	38	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1597997181 CA399829213	38	D>Y		No	ClinGen Ensembl
CA8610416 rs750844557	40	S>R		No	ClinGen ExAC TOPMed gnomAD
rs756247053 CA8610418	41	Y>C		No	ClinGen ExAC gnomAD
CA291007245 rs946116469	42	N>S		No	ClinGen gnomAD
rs1271597368 CA399829325	43	R>P		No	ClinGen gnomAD
CA399829319 rs1597997204	43	R>W		No	ClinGen Ensembl
CA399834140 rs752810524	45	G>D		No	ClinGen ExAC TOPMed
rs752810524 CA8610443	45	G>V		No	ClinGen ExAC TOPMed
rs758247752 CA8610444	46	L>V		No	ClinGen ExAC gnomAD
rs1199096532 CA399834162	46	L>W		No	ClinGen gnomAD
rs1286861992 CA399834190	47	S>N		No	ClinGen gnomAD
CA399834218 rs1192808116	48	P>A		No	ClinGen gnomAD
rs1212522731 CA399834232	48	P>L		No	ClinGen TOPMed
CA8610446 rs140455291	50	N>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8610447 rs757177482	50	N>S		No	ClinGen ExAC TOPMed gnomAD
rs780748535 CA8610448	54	A>V		No	ClinGen ExAC gnomAD
CA8610449 rs774451911	55	K>I		No	ClinGen ExAC gnomAD
CA8610450 rs774451911	55	K>R		No	ClinGen ExAC gnomAD
TCGA novel	56	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	56	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1468231466 CA399834484	59	K>R		No	ClinGen gnomAD
rs3087878 CA291018100 VAR_050286	61	Q>K		No	ClinGen UniProt Ensembl dbSNP
rs1567865446	63	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	64	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399834591 rs201559014	64	K>M		No	ClinGen 1000Genomes TOPMed
CA291018109 rs201559014	64	K>R		No	ClinGen 1000Genomes TOPMed
rs779784731 CA8610451	65	K>E		No	ClinGen ExAC gnomAD
TCGA novel	66	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	68	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399834663 rs1399730029	68	G>V		No	ClinGen gnomAD
rs1405046109 CA399834752	74	A>S		No	ClinGen gnomAD
rs1284414737 CA399834765	74	A>V		No	ClinGen gnomAD
CA399834783 rs1231776580	75	Q>H		No	ClinGen gnomAD
rs1281614790 CA399834807	77	Q>K		No	ClinGen TOPMed gnomAD
CA8610455 rs761306458	79	V>M		No	ClinGen ExAC gnomAD
rs767459577 CA8610467	81	M>V		No	ClinGen ExAC gnomAD
CA8610468 rs367954716	82	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA399836488 rs367954716	82	N>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1018863986 TCGA novel CA291020761	84	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen Ensembl
CA399836599 rs1567867068	86	A>T		No	ClinGen Ensembl
rs1051019368 CA291020762	87	E>D		No	ClinGen TOPMed
CA8610470 rs779405921	89	I>M		No	ClinGen ExAC gnomAD
TCGA novel	95	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399836796 rs1308984921	96	I>T		No	ClinGen TOPMed
rs1463089836 CA399836784	96	I>V		No	ClinGen TOPMed gnomAD
rs778561485 CA8610473	101	V>E		No	ClinGen ExAC gnomAD
rs747390700 CA8610474	102	G>C		No	ClinGen ExAC gnomAD
rs771371139 CA8610475	103	Q>H		No	ClinGen ExAC gnomAD
CA399836952 rs1335366133	103	Q>R		No	ClinGen TOPMed
rs563736659 CA8610476 COSM1493963	104	G>R	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
CA399837007 rs1416691571	105	P>L		No	ClinGen TOPMed
rs1294041634 CA399837001	105	P>T		No	ClinGen TOPMed
rs868718436 CA291020791	106	A>T		No	ClinGen Ensembl
CA8610478 rs770043528	109	M>T		No	ClinGen ExAC gnomAD
rs1348860194 CA399837075	109	M>V		No	ClinGen TOPMed
CA8610479 rs775419569	111	E>G		No	ClinGen ExAC
rs1297768336 CA399837126	112	A>S		No	ClinGen TOPMed
rs1443418786 CA399837133	112	A>V		No	ClinGen TOPMed
rs1196722115 CA399837140	113	S>G		No	ClinGen gnomAD
CA8610480 rs377156745	115	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA399837179 COSM436718 rs377156745	115	R>Q	Variant assessed as Somatic; impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1182546534 CA399837188	116	S>R		No	ClinGen gnomAD
rs1391284036 CA399837251	118	Q>R		No	ClinGen gnomAD
rs764230766 CA8610481 COSM1679873	122	T>M	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs764230766 CA399837345	122	T>R		No	ClinGen ExAC TOPMed gnomAD
CA8610483 rs761622308	125	V>I		No	ClinGen ExAC TOPMed gnomAD
rs144433221 CA8610485	127	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs199678185	129	G>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1216003679 CA399839295	131	V>E		No	ClinGen gnomAD
CA8610505 rs753759265	135	H>Y		No	ClinGen ExAC gnomAD
rs752448187 CA8610508	138	V>M		No	ClinGen ExAC gnomAD
CA399839468 rs1421268751	140	P>L		No	ClinGen gnomAD
rs758111913 CA8610509	140	P>S		No	ClinGen ExAC gnomAD
rs201386803 CA8610510	141	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA291028604 rs986408291	142	K>E		No	ClinGen Ensembl
CA399839519 rs1598015358	143	D>A		No	ClinGen Ensembl
rs955288678 CA291028609	146	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1161073719 CA399839584	147	Q>K		No	ClinGen TOPMed
rs1305018160 CA399839608	148	E>K		No	ClinGen TOPMed gnomAD
CA399839637 rs1366323829	149	P>A		No	ClinGen gnomAD
TCGA novel	152	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399839697 rs1567869371	153	P>S		No	ClinGen Ensembl
rs1435626124 CA399839706	154	Q>*		No	ClinGen gnomAD
TCGA novel	155	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1291739811 CA399839734	155	G>S		No	ClinGen gnomAD
CA291028642 rs1132898	163	L>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149737135 CA8610515	165	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8610516 rs778948844	166	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs748432196 CA8610517	166	R>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA399840010 rs1269207571	167	G>S		No	ClinGen TOPMed
rs773364852 CA8610519	168	V>M		No	ClinGen ExAC TOPMed gnomAD
CA399842249 rs1283407561	187	M>V		No	ClinGen TOPMed
CA399842314 rs1567870315 COSM980091	189	R>Q	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs775510228 CA8610542	194	P>L		No	ClinGen ExAC gnomAD
rs775510228 CA399842412	194	P>Q		No	ClinGen ExAC gnomAD
CA399842431 rs1445433341	195	E>A		No	ClinGen gnomAD
CA291030060 rs866488889	195	E>D		No	ClinGen Ensembl
CA399842425 rs1339503876	195	E>K		No	ClinGen gnomAD
rs1311826897 CA399842447	196	F>L		No	ClinGen TOPMed
TCGA novel	197	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs150418753 CA8610573	202	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs764148755 CA8610572	202	R>W		No	ClinGen ExAC TOPMed gnomAD
CA8610575 rs781499966	205	G>S		No	ClinGen ExAC TOPMed gnomAD
rs746041079 CA8610576	206	W>C		No	ClinGen ExAC gnomAD
CA8610577 rs756018179	207	L>V		No	ClinGen ExAC gnomAD
CA8610578 rs779975972	208	P>H		No	ClinGen ExAC TOPMed gnomAD
rs779975972 CA8610579	208	P>L		No	ClinGen ExAC TOPMed gnomAD
CA399842778 rs1598017200	209	Q>P		No	ClinGen Ensembl
TCGA novel	209	Q>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399842819 rs1598017204	211	H>Q		No	ClinGen Ensembl
CA8610581 rs774095582	217	V>L		No	ClinGen ExAC gnomAD
rs771441667 CA8610583	220	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA399842941 rs1407256029	220	R>W		No	ClinGen gnomAD
rs1303544092 CA399843056	226	I>M		No	ClinGen gnomAD
CA291030756 rs919282095	227	S>G		No	ClinGen TOPMed
TCGA novel	228	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8610585 rs375089291	229	I>M		No	ClinGen ESP ExAC gnomAD
rs775829411 CA8610587	234	H>R		No	ClinGen ExAC TOPMed gnomAD
CA8610588 rs763238851	236	Y>C		No	ClinGen ExAC gnomAD
CA399843264 rs1342497115	238	T>A		No	ClinGen TOPMed
CA291030787 rs764674925	238	T>I		No	ClinGen ExAC TOPMed gnomAD
rs764674925 CA8610589	238	T>K		No	ClinGen ExAC TOPMed gnomAD
rs758261924 CA8610620	241	K>M		No	ClinGen ExAC TOPMed gnomAD
CA8610621 rs777621617	242	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1331451303 CA399843798	249	C>G		No	ClinGen TOPMed
rs746537411 CA8610622	255	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1429798567 CA399844044	261	P>A		No	ClinGen gnomAD
rs1567871129 CA399844111	265	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA399844207 rs1422769066	274	E>Q		No	ClinGen gnomAD
rs367724198 CA291031377	275	G>S		No	ClinGen ESP TOPMed
rs371122860 CA8610627	276	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA399844295 rs1196654054	279	A>G		No	ClinGen TOPMed
rs772467109 CA8610629	280	V>F		No	ClinGen ExAC gnomAD
TCGA novel	281	Y>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1302511754 CA399844338	283	A>T		No	ClinGen gnomAD
rs766531390 CA8610632	284	G>E		No	ClinGen ExAC gnomAD
CA399844385 rs759663986	287	L>I		No	ClinGen ExAC TOPMed gnomAD
rs759663986 CA8610634	287	L>V		No	ClinGen ExAC TOPMed gnomAD
CA8610637 rs376218058	291	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA8610638 rs764042790	292	G>V		No	ClinGen ExAC gnomAD
rs1204184516 CA399845166	299	R>Q		No	ClinGen TOPMed
CA399845226 rs1441741328	304	R>W		No	ClinGen gnomAD
CA399845242 rs2239923	306	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399845334 rs1326078809	317	N>H		No	ClinGen TOPMed
rs1435733070 CA399845350	318	M>R		No	ClinGen gnomAD
rs1244829195 CA399845383	320	M>I		No	ClinGen gnomAD
rs760110087 CA291031835	323	T>S		No	ClinGen Ensembl
rs1291541781 CA399845448	324	M>R		No	ClinGen gnomAD
CA399845530 rs1447003290	328	R>G		No	ClinGen gnomAD
rs1384334634 CA399845536	328	R>Q		No	ClinGen TOPMed
rs1193969791 CA399845557	329	L>P		No	ClinGen gnomAD
rs1373930583 CA399845562	330	P>T		No	ClinGen gnomAD
rs767459640 CA8610678	332	T>A		No	ClinGen ExAC gnomAD
CA399845925 rs750330678	332	T>N		No	ClinGen ExAC gnomAD
CA8610679 rs750330678	332	T>S		No	ClinGen ExAC gnomAD
rs1271946369 CA399845929	333	P>S		No	ClinGen TOPMed
rs375623297 CA291033650	335	T>I		No	ClinGen ESP TOPMed gnomAD
rs1213935690 CA399845979	335	T>S		No	ClinGen TOPMed
rs760138330 CA8610680	336	A>T		No	ClinGen ExAC TOPMed gnomAD
CA399846007 rs1336327252	336	A>V		No	ClinGen TOPMed
COSM187889 rs1415777939 CA399846042	339	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA8610681 rs554809034	341	M>V		No	ClinGen ExAC TOPMed gnomAD
CA399846119 rs1567872686	343	T>A		No	ClinGen Ensembl
CA399846172 rs1358012081	347	P>A		No	ClinGen gnomAD
rs1358012081 CA399846173	347	P>S		No	ClinGen gnomAD
rs753488937 CA8610682	348	V>L		No	ClinGen ExAC gnomAD
rs754671896 CA8610683	350	H>Y		No	ClinGen ExAC gnomAD
rs778639871 CA8610684	352	L>F		No	ClinGen ExAC gnomAD
rs1567872701 CA399846228	353	L>V		No	ClinGen Ensembl
rs757647993 CA291033677	355	R>K		No	ClinGen ExAC TOPMed gnomAD
rs757647993 CA8610686	355	R>M		No	ClinGen ExAC TOPMed gnomAD
CA399846279 rs1442131409	357	L>F		No	ClinGen gnomAD
TCGA novel	360	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399846351 rs1396950068	361	H>Y		No	ClinGen TOPMed
rs1208099201 CA399846404	363	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA399846410 rs1352058986	364	P>T		No	ClinGen gnomAD
rs1192890144 CA399846434	365	V>D		No	ClinGen gnomAD
CA8610690 rs148483868	365	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs943116623 CA291033706	372	E>K		No	ClinGen TOPMed gnomAD
TCGA novel	374	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA399846636 rs1567872739	376	Y>C		No	ClinGen Ensembl
CA399846653 rs1478893273	377	P>S		No	ClinGen gnomAD
CA399846722 rs1412459058	381	I>V		No	ClinGen gnomAD
rs1360643122 CA399846756	383	D>N		No	ClinGen gnomAD
rs1401094663 CA399846793	385	F>I		No	ClinGen gnomAD
CA399846796 rs1401094663	385	F>L		No	ClinGen gnomAD
rs1324984572 CA399846842	387	V>L		No	ClinGen gnomAD
rs1275875591 CA399846878	388	E>D		No	ClinGen gnomAD
CA399847526 rs1259100523	389	N>S		No	ClinGen gnomAD
rs749387380 CA8610708	390	A>S		No	ClinGen ExAC gnomAD
CA399847534 rs749387380	390	A>T		No	ClinGen ExAC gnomAD
CA399847542 rs1288820933	390	A>V		No	ClinGen gnomAD
COSM1217528 CA8610710 rs779143534	392	G>R	large_intestine prostate [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs983756350 CA291035623	393	E>G		No	ClinGen TOPMed
CA8610711 rs748344051	393	E>K		No	ClinGen ExAC gnomAD
rs773052955 COSM1679874 CA8610713	402	T>M	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs770912575 CA8610715	407	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8610716 rs776660504	412	T>N		No	ClinGen ExAC gnomAD
rs1333869222 CA399847836	415	S>N		No	ClinGen gnomAD
rs1186266047 CA399847842	415	S>R		No	ClinGen Ensembl
rs775334053 CA8610719	424	N>S		No	ClinGen ExAC gnomAD
CA8610721 rs767839828	425	V>I		No	ClinGen ExAC gnomAD
CA399847999 rs1462397852	428	Q>H		No	ClinGen TOPMed gnomAD
rs750807200 CA8610722	435	M>I		No	ClinGen ExAC TOPMed gnomAD
rs766935430 CA8610724	437	D>N		No	ClinGen ExAC gnomAD
rs755095071 CA8610726	438	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA399848129 rs1241960333	439	L>F		No	ClinGen TOPMed
CA291035727 rs867687573	442	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	447	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA291036701 rs1802201	448	D>N		No	ClinGen Ensembl
rs908761902 CA291036707	450	F>L		No	ClinGen Ensembl
rs1350193710 CA399848421	451	N>S		No	ClinGen gnomAD
CA399848429 rs1460724762	452	A>T		No	ClinGen TOPMed gnomAD
rs1279886973 CA399848435	452	A>V		No	ClinGen gnomAD
rs1276441766 CA399848478	456	M>L		No	ClinGen TOPMed
rs1401993695 CA399848531	459	K>E		No	ClinGen gnomAD
CA8610781 rs772801108	460	T>N		No	ClinGen ExAC gnomAD
CA399848574 rs141629884	462	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	465	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8610787 rs774301899	469	I>V		No	ClinGen ExAC TOPMed gnomAD
CA399848706 rs1232327561	472	G>S		No	ClinGen gnomAD
rs1426104773 CA399848804	479	Y>C		No	ClinGen TOPMed
TCGA novel	481	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs867051835 CA291036741	481	W>C		No	ClinGen Ensembl
rs898816298 CA291036745	482	K>I		No	ClinGen Ensembl
CA399848908 rs1474867123	486	M>L		No	ClinGen TOPMed gnomAD
CA399848906 rs1474867123	486	M>V		No	ClinGen TOPMed gnomAD
rs1162489791 CA399848933	487	G>A		No	ClinGen gnomAD
rs1425544391 CA399848946	488	A>V		No	ClinGen gnomAD
rs578117787 CA8610791	489	E>G		No	ClinGen 1000Genomes ExAC gnomAD
CA8610792 rs766069961	490	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1449583852 CA399848972	490	K>R		No	ClinGen gnomAD
TCGA novel	491	V>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8610814 rs765115917	493	L>V		No	ClinGen ExAC gnomAD
rs1421300928 CA399849430	497	Q>L		No	ClinGen TOPMed

No associated diseases with P30419

4 regional properties for P30419

Type	Name	Position	InterPro Accession
domain	Glycylpeptide N-tetradecanoyltransferase, N-terminal	141 - 294	IPR022676
domain	Glycylpeptide N-tetradecanoyltransferase, C-terminal	308 - 486	IPR022677
conserved_site	Glycylpeptide N-tetradecanoyltransferase, conserved site	244 - 252	IPR022678-1
conserved_site	Glycylpeptide N-tetradecanoyltransferase, conserved site	466 - 472	IPR022678-2

Functions

		Description
EC Number	2.3.1.97	Transferring groups other than amino-acyl groups
Subcellular Localization	Cytoplasm Cytoplasm, cytosol Membrane ; Peripheral membrane protein	Copurifies with ribosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of membrane	The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name	Definition
glycylpeptide N-tetradecanoyltransferase activity	Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.
myristoyltransferase activity	Catalysis of the transfer of a myristoyl (CH3-12-CO-) group to an acceptor molecule.
peptidyl-lysine N6-myristoyltransferase activity	Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule.

6 GO annotations of biological process

Name	Definition
cellular ketone metabolic process	The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
in utero embryonic development	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
N-terminal peptidyl-glycine N-myristoylation	The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine.
N-terminal protein myristoylation	The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway.
regulation of rhodopsin mediated signaling pathway	Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O70310	Nmt1	Glycylpeptide N-tetradecanoyltransferase 1	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MADESETAVK	PPAPPLPQMM	EGNGNGHEHC	SDCENEEDNS	YNRGGLSPAN	DTGAKKKKKK
70	80	90	100	110	120
QKKKKEKGSE	TDSAQDQPVK	MNSLPAERIQ	EIQKAIELFS	VGQGPAKTME	EASKRSYQFW
130	140	150	160	170	180
DTQPVPKLGE	VVNTHGPVEP	DKDNIRQEPY	TLPQGFTWDA	LDLGDRGVLK	ELYTLLNENY
190	200	210	220	230	240
VEDDDNMFRF	DYSPEFLLWA	LRPPGWLPQW	HCGVRVVSSR	KLVGFISAIP	ANIHIYDTEK
250	260	270	280	290	300
KMVEINFLCV	HKKLRSKRVA	PVLIREITRR	VHLEGIFQAV	YTAGVVLPKP	VGTCRYWHRS
310	320	330	340	350	360
LNPRKLIEVK	FSHLSRNMTM	QRTMKLYRLP	ETPKTAGLRP	METKDIPVVH	QLLTRYLKQF
370	380	390	400	410	420
HLTPVMSQEE	VEHWFYPQEN	IIDTFVVENA	NGEVTDFLSF	YTLPSTIMNH	PTHKSLKAAY
430	440	450	460	470	480
SFYNVHTQTP	LLDLMSDALV	LAKMKGFDVF	NALDLMENKT	FLEKLKFGIG	DGNLQYYLYN
490
WKCPSMGAEK	VGLVLQ