O70310

PR
Gene name
Nmt1
Protein name
Glycylpeptide N-tetradecanoyltransferase 1
Names
Myristoyl-CoA:protein N-myristoyltransferase 1, NMT 1, Type I N-myristoyltransferase, Peptide N-myristoyltransferase 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18107
EC number
2.3.1.97: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O70310

Entry ID Method Resolution Chain Position Source
AF-O70310-F1 Predicted AlphaFoldDB

12 variants for O70310

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389218902 70 D>Y No EVA
rs3412972004 74 T>I No EVA
rs3402819039 85 P>L No EVA
rs3389182395 140 P>H No EVA
rs3389211928 176 L>Q No EVA
rs3389195940 203 P>L No EVA
rs3402700283 214 V>G No EVA
rs3389206540 216 V>M No EVA
rs3389221351 268 T>I No EVA
rs3402892844 296 Y>S No EVA
rs581797362 368 Q>E No EVA
rs3389215887 370 E>K No EVA

No associated diseases with O70310

4 regional properties for O70310

Type Name Position InterPro Accession
domain Ribosomal protein S3, C-terminal 120 - 202 IPR001351
domain K Homology domain, type 2 39 - 110 IPR004044
domain K Homology domain 60 - 125 IPR004087
conserved_site Ribosomal protein S3, conserved site 163 - 197 IPR018280

Functions

Description
EC Number 2.3.1.97 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytosol
  • Membrane ; Peripheral membrane protein
  • Copurifies with ribosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
glycylpeptide N-tetradecanoyltransferase activity Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.
myristoyltransferase activity Catalysis of the transfer of a myristoyl (CH3-12-CO-) group to an acceptor molecule.
peptidyl-lysine N6-myristoyltransferase activity Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule.

4 GO annotations of biological process

Name Definition
cellular ketone metabolic process The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
in utero embryonic development The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
N-terminal peptidyl-glycine N-myristoylation The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine.
N-terminal protein myristoylation The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MADESETAVK LPAPSLPLMM EGNGNGHEHC SDCENEEDNS HNRSGLSPAN DTGAKKKKKK
70 80 90 100 110 120
QKKKKEKGSD MESTQDQPVK MTSLPAERIQ EIQKAIELFS VGQGPAKTME EASKRSYQFW
130 140 150 160 170 180
DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY TLPQGFTWDA LDLGDRGVLK ELYTLLNENY
190 200 210 220 230 240
VEDDDNMFRF DYSPEFLLWA LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK
250 260 270 280 290 300
KMVEINFLCV HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS
310 320 330 340 350 360
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP MEKKDIPVVH QLLSRYLKQF
370 380 390 400 410 420
HLTPVMNQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF YTLPSTIMNH PTHKSLKAAY
430 440 450 460 470 480
SFYNVHTQTP LLDLMSDALV LAKMKGFDVF NALDLMENKT FLEKLKFGIG DGNLQYYLYN
490
WKCPSMGAEK VGLVLQ