P27674

PR
Gene name
SLC2A1
Protein name
Solute carrier family 2, facilitated glucose transporter member 1
Names
Glucose transporter type 1, erythrocyte/brain, GLUT-1
Species
Bos taurus (Bovine)
KEGG Pathway
bta:282356
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

208-282 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P27674

Entry ID Method Resolution Chain Position Source
AF-P27674-F1 Predicted AlphaFoldDB

195 variants for P27674

Variant ID(s) Position Change Description Diseaes Association Provenance
rs447317034 2 E>A No EVA
rs457719782 2 E>D No EVA
rs478143597 3 P>A No EVA
rs449919365 4 T>N No EVA
rs469980200 5 S>N No EVA
rs435343196 6 K>M No EVA
rs435343196 6 K>R No EVA
rs473141709 7 K>N No EVA
rs458194843 8 L>P No EVA
rs478332252 9 T>A No EVA
rs443682267 9 T>K No EVA
rs478332252 9 T>P No EVA
rs463748204 11 R>P No EVA
rs480917968 12 L>P No EVA
rs449562805 13 M>I No EVA
rs466400008 15 A>P No EVA
rs480043420 16 V>G No EVA
rs445405477 17 G>A No EVA
rs445405477 17 G>E No EVA
rs436852528 19 A>G No EVA
rs467157531 20 V>G No EVA
rs456823954 20 V>L No EVA
rs453056287 27 G>A No EVA
rs438618828 31 G>* No EVA
rs471922255 32 V>G No EVA
rs443696481 35 A>T No EVA
rs473467792 39 V>A No EVA
rs473467792 39 V>G No EVA
rs432557821 41 E>K No EVA
rs452620863 42 E>A No EVA
rs475587191 42 E>D No EVA
rs452620863 42 E>G No EVA
rs460981941 43 F>L No EVA
rs444080324 43 F>S No EVA
rs474632961 44 Y>D No EVA
rs439997268 45 N>I No EVA
rs460446931 45 N>K No EVA
rs439997268 45 N>T No EVA
rs477254162 46 Q>E No EVA
rs477254162 46 Q>K No EVA
rs445907398 47 T>A No EVA
rs445907398 47 T>P No EVA
rs462713862 47 T>R No EVA
rs445907398 47 T>S No EVA
rs482405680 48 W>G No EVA
rs482405680 48 W>R No EVA
rs467861273 49 V>A No EVA
rs450873568 49 V>F No EVA
rs467861273 49 V>G No EVA
rs446757457 50 Q>P No EVA
rs446757457 50 Q>R No EVA
rs467102411 51 R>P No EVA
rs452713194 52 Y>* No EVA
rs432641732 52 Y>F No EVA
rs475987135 54 E>* No EVA
rs438162505 54 E>A No EVA
rs454558432 54 E>D No EVA
rs474659886 55 P>H No EVA
rs440034418 56 I>L No EVA
rs460130695 56 I>T No EVA
rs470922642 57 P>A No EVA
rs470922642 57 P>T No EVA
rs462778608 59 A>P No EVA
rs482907898 60 T>P No EVA
rs481271669 62 T>A No EVA
rs481271669 62 T>P No EVA
rs446843414 63 T>A No EVA
rs446843414 63 T>P No EVA
rs477536271 64 L>H No EVA
rs469664844 65 W>C No EVA
rs446332347 65 W>S No EVA
rs438196105 66 S>A No EVA
rs438196105 66 S>P No EVA
rs455072578 67 L>M No EVA
rs468318724 68 S>A No EVA
rs468318724 68 S>P No EVA
rs470558993 77 M>I No EVA
rs469518447 79 G>C No EVA
rs439159775 83 V>L No EVA
rs476502053 85 L>F No EVA
rs461771778 86 F>L No EVA
rs481357488 87 V>F No EVA
rs440444684 88 N>D No EVA
rs460452654 89 R>G No EVA
rs445986263 90 F>L No EVA
rs477227386 90 F>S No EVA
rs483314613 92 R>P No EVA
rs434549435 122 L>P No EVA
rs451395123 126 R>L No EVA
rs439668915 137 T>P No EVA
rs462937647 147 V>G No EVA
rs461212171 173 V>E No EVA
rs461212171 173 V>G No EVA
rs481223133 175 G>A No EVA
rs466314322 176 L>P No EVA
rs434871821 177 D>G No EVA
rs445264421 178 S>F No EVA
rs437162281 180 M>R No EVA
rs457490380 185 L>M No EVA
rs436554555 201 C>G No EVA
rs453376576 205 P>H No EVA
rs472950611 206 F>C No EVA
rs438467951 210 S>R No EVA
rs458576453 212 R>P No EVA
rs475428145 215 L>H No EVA
rs481311801 217 N>T No EVA
rs446704036 219 N>I No EVA
rs460322405 220 E>* No EVA
rs479983309 221 E>* No EVA
rs445316243 222 N>T No EVA
rs465441000 225 K>R No EVA
rs437187550 226 S>R No EVA
rs470859594 234 T>A No EVA
rs439432683 234 T>N No EVA
rs482410983 240 D>G No EVA
rs461252401 243 E>A No EVA
rs461252401 243 E>G No EVA
rs481234788 244 M>L No EVA
rs446753539 245 K>E No EVA
rs467289356 245 K>M No EVA
rs477731662 246 E>G No EVA
rs469582776 248 S>N No EVA
rs446238502 248 S>R No EVA
rs438181599 250 Q>K No EVA
rs454641248 251 M>L No EVA
rs468230937 253 R>G No EVA
rs433561654 254 E>A No EVA
rs453680583 255 K>R No EVA
rs470911363 256 K>T No EVA
rs433053389 257 V>D No EVA
rs456295952 258 T>S No EVA
rs476237043 260 L>P No EVA
rs441731228 264 R>S No EVA
rs461289310 265 S>A No EVA
rs135388257 267 A>P No EVA
rs133236740 268 Y>D No EVA
rs133236740 268 Y>H No EVA
rs134711046 268 Y>S No EVA
rs440436047 270 Q>P No EVA
rs460539585 274 I>S No EVA
rs477786264 276 V>A No EVA
rs483218140 279 Q>H No EVA
rs448653529 282 Q>K No EVA
rs433651650 284 L>V No EVA
rs456554838 290 V>G No EVA
rs476623137 294 S>P No EVA
rs442005780 296 S>R No EVA
rs456036912 298 F>S No EVA
rs472828805 299 E>A No EVA
rs441449258 302 G>A No EVA
rs477972996 303 V>G No EVA
rs458258278 303 V>L No EVA
rs443307388 306 P>A No EVA
rs480030206 307 V>G No EVA
rs459696434 308 Y>C No EVA
rs448752685 308 Y>D No EVA
rs479752792 310 T>P No EVA
rs445059867 316 V>L No EVA
rs465098448 317 N>T No EVA
rs436960478 318 T>P No EVA
rs383128027 320 F>L No EVA
rs450226162 322 V>A No EVA
rs797283183 323 V>M No EVA
rs435581852 324 S>P No EVA
rs432041425 326 F>C No EVA
rs452155142 326 F>L No EVA
rs475416192 327 V>G No EVA
rs444004215 328 V>G No EVA
rs454825840 329 E>* No EVA
rs440237436 329 E>D No EVA
rs474899414 329 E>G No EVA
rs438906529 335 T>P No EVA
rs482032641 339 I>V No EVA
rs450750563 342 A>S No EVA
rs447035864 346 G>S No EVA
rs432542643 347 C>Y No EVA
rs437644806 351 M>I No EVA
rs469024518 351 M>R No EVA
rs454516260 352 T>P No EVA
rs474945887 353 I>M No EVA
rs433849675 354 A>P No EVA
rs453915811 355 L>V No EVA
rs439319994 357 L>R No EVA
rs455441329 380 E>A No EVA
rs468734627 386 I>V No EVA
rs434052933 387 P>Q No EVA
rs454177840 406 V>F No EVA
rs480405904 408 G>V No EVA
rs449061566 410 S>C No EVA
rs471002864 420 M>R No EVA
rs433116354 426 E>A No EVA
rs433243001 430 G>R No EVA
rs470194413 436 I>M No EVA
rs455976779 446 I>T No EVA
rs466438496 466 G>C No EVA

No associated diseases with P27674

3 regional properties for P27674

Type Name Position InterPro Accession
conserved_site Sugar transporter, conserved site 128 - 153 IPR005829-1
conserved_site Sugar transporter, conserved site 324 - 340 IPR005829-2
domain Major facilitator superfamily domain 15 - 456 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
  • Photoreceptor inner segment
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

15 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
female germ cell nucleus The nucleus of the female germ cell, a reproductive cell in females.
female pronucleus The pronucleus originating from the ovum that is being fertilized.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
photoreceptor inner segment The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
presynapse The part of a synapse that is part of the presynaptic cell.
vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.

7 GO annotations of molecular function

Name Definition
D-glucose transmembrane transporter activity Enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other.
dehydroascorbic acid transmembrane transporter activity Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other.
glucose transmembrane transporter activity Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other.
hexose transmembrane transporter activity Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other.
identical protein binding Binding to an identical protein or proteins.
long-chain fatty acid transporter activity Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
protein self-association Binding to a domain within the same polypeptide.

12 GO annotations of biological process

Name Definition
cellular response to glucose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
central nervous system development The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
dehydroascorbic acid transport The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C.
glucose import The directed movement of the hexose monosaccharide glucose into a cell or organelle.
glucose import across plasma membrane The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol.
glucose transmembrane transport The process in which glucose is transported across a membrane.
long-chain fatty acid import across plasma membrane The directed movement of long-chain fatty acids from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.
monosaccharide transmembrane transport The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.
photoreceptor cell maintenance Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
protein-containing complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
transport across blood-brain barrier The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P58352 SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3 Bos taurus (Bovine) PR
P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 Homo sapiens (Human) PR
P17809 Slc2a1 Solute carrier family 2, facilitated glucose transporter member 1 Mus musculus (Mouse) PR
P20303 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 Sus scrofa (Pig) PR
10 20 30 40 50 60
MEPTSKKLTG RLMLAVGGAV LGSLQFGYNT GVINAPQKVI EEFYNQTWVQ RYGEPIPPAT
70 80 90 100 110 120
LTTLWSLSVA IFSVGGMIGS FSVGLFVNRF GRRNSMLMMN LLAFVSAVLM GFSKLGKSFE
130 140 150 160 170 180
MLILGRFIIG VYCGLTTGFV PMYVGEVSPT ELRGALGTLH QLGIVVGILI AQVFGLDSIM
190 200 210 220 230 240
GNQELWPLLL SVIFIPALLQ CILLPFCPES PRFLLINRNE ENRAKSVLKK LRGTADVTRD
250 260 270 280 290 300
LQEMKEESRQ MMREKKVTIL ELFRSAAYRQ PILIAVVLQL SQQLSGINAV FYYSTSIFEK
310 320 330 340 350 360
AGVQQPVYAT IGSGIVNTAF TVVSLFVVER AGRRTLHLIG LAGMAGCAVL MTIALALLER
370 380 390 400 410 420
LPWMSYLSIV AIFGFVAFFE VGPGPIPWFI VAELFSQGPR PAAIAVAGFS NWTSNFIVGM
430 440 450 460 470 480
CFQYVEQLCG PYVFIIFTVL LVLFFIFTYF KVPETKGRTF DEIASGFRQG GASQSDKTPE
490
ELFHPLGADS QV