P27089

PR
Gene name
XPA (XPAC)
Protein name
DNA repair protein complementing XP-A cells homolog
Names
Xeroderma pigmentosum group A-complementing protein homolog
Species
Gallus gallus (Chicken)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-120 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P27089

Entry ID Method Resolution Chain Position Source
AF-P27089-F1 Predicted AlphaFoldDB

No variants for P27089

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P27089

No associated diseases with P27089

3 regional properties for P27089

Type Name Position InterPro Accession
conserved_site Zinc finger, XPA-type, conserved site 97 - 127 IPR022652
domain XPA, C-terminal 129 - 180 IPR022656
conserved_site XPA, conserved site 132 - 148 IPR022658

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

2 GO annotations of molecular function

Name Definition
damaged DNA binding Binding to damaged DNA.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P23025 XPA DNA repair protein complementing XP-A cells Homo sapiens (Human) PR
Q64267 Xpa DNA repair protein complementing XP-A cells homolog Mus musculus (Mouse) PR
10 20 30 40 50 60
MGRAAPGPDE GAEGERPSIS ATALARMERN RRRALALRQA RLAARPYPQA AAGAGPPQGR
70 80 90 100 110 120
DTGGGFFLEE EEEEEEQRRA AERIVHPPAP VLQFDYLICG DCGKEFMDSY LMQHFDWATC
130 140 150 160 170 180
DNCRDAEDKH KLITRTEAKE EYLLKDCDLD KREPVLRFIV KKNPHNPRWG DMKLYLKLQV
190 200 210 220 230 240
IKRALEVWGN EESLQEAKEQ RRDSREKMKQ KRFDKKVKEL RRAVRSSLWK KTASIHEHEY
250 260
GPEENVDEET YKKTCTVCGH ELTYEKM