P25044

PR
Gene name
PTP1 (YDL230W)
Protein name
Tyrosine-protein phosphatase 1
Names
Protein-tyrosine phosphatase 1, PTPase 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDL230W
EC number
3.1.3.48: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P25044

Entry ID Method Resolution Chain Position Source
AF-P25044-F1 Predicted AlphaFoldDB

7 variants for P25044

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-42849 50 P>L No SGRP
s04-42915 72 K>R No SGRP
s04-42971 91 G>R No SGRP
s04-43020 107 R>H No SGRP
s04-43076 126 I>V No SGRP
s04-43157 153 D>N No SGRP
s04-43688 330 S>G No SGRP

No associated diseases with P25044

4 regional properties for P25044

Type Name Position InterPro Accession
domain Tyrosine-specific protein phosphatase, PTPase domain 15 - 330 IPR000242
domain Tyrosine-specific protein phosphatases domain 226 - 319 IPR000387
domain Protein-tyrosine phosphatase, catalytic 210 - 327 IPR003595
active_site Protein-tyrosine phosphatase, active site 250 - 260 IPR016130

Functions

Description
EC Number 3.1.3.48 Phosphoric monoester hydrolases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

3 GO annotations of biological process

Name Definition
invasive growth in response to glucose limitation A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
protein dephosphorylation The process of removing one or more phosphoric residues from a protein.
pseudohyphal growth The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P08575 PTPRC Receptor-type tyrosine-protein phosphatase C Homo sapiens (Human) PR
10 20 30 40 50 60
MAAAPWYIRQ RDTDLLGKFK FIQNQEDGRL REATNGTVNS RWSLGVSIEP RNDARNRYVN
70 80 90 100 110 120
IMPYERNRVH LKTLSGNDYI NASYVKVNVP GQSIEPGYYI ATQGPTRKTW DQFWQMCYHN
130 140 150 160 170 180
CPLDNIVIVM VTPLVEYNRE KCYQYWPRGG VDDTVRIASK WESPGGANDM TQFPSDLKIE
190 200 210 220 230 240
FVNVHKVKDY YTVTDIKLTP TDPLVGPVKT VHHFYFDLWK DMNKPEEVVP IMELCAHSHS
250 260 270 280 290 300
LNSRGNPIIV HCSAGVGRTG TFIALDHLMH DTLDFKNITE RSRHSDRATE EYTRDLIEQI
310 320 330
VLQLRSQRMK MVQTKDQFLF IYHAAKYLNS LSVNQ